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FKB19_ARATH
ID   FKB19_ARATH             Reviewed;         256 AA.
AC   Q9LYR5; B9DFP6; Q682Z9;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 127.
DE   RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP19, chloroplastic;
DE            Short=PPIase FKBP19;
DE            EC=5.2.1.8;
DE   AltName: Full=FK506-binding protein 19;
DE            Short=AtFKBP19;
DE   AltName: Full=Immunophilin FKBP19;
DE   AltName: Full=Rotamase;
DE   Flags: Precursor;
GN   Name=FKBP19; Synonyms=FKBP27; OrderedLocusNames=At5g13410;
GN   ORFNames=T22N19.60;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA   Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA   Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA   O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA   Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA   Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA   Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA   Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA   Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA   Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA   Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA   Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Shinn P., Chen H., Cheuk R.F., Kim C.J., Carninci P., Hayashizaki Y.,
RA   Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA   Shinozaki K., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia; TISSUE=Rosette leaf;
RX   PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA   Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA   Shinozaki K.;
RT   "Analysis of multiple occurrences of alternative splicing events in
RT   Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL   DNA Res. 16:155-164(2009).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-256.
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   PROTEIN SEQUENCE OF 89-112, AND SUBCELLULAR LOCATION.
RX   PubMed=11719511; DOI=10.1074/jbc.m108575200;
RA   Schubert M., Petersson U.A., Haas B.J., Funk C., Schroeder W.P.,
RA   Kieselbach T.;
RT   "Proteome map of the chloroplast lumen of Arabidopsis thaliana.";
RL   J. Biol. Chem. 277:8354-8365(2002).
RN   [7]
RP   PROTEIN SEQUENCE OF N-TERMINUS, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=11826309; DOI=10.1105/tpc.010304;
RA   Peltier J.-B., Emanuelsson O., Kalume D.E., Ytterberg J., Friso G.,
RA   Rudella A., Liberles D.A., Soederberg L., Roepstorff P., von Heijne G.,
RA   van Wijk K.J.;
RT   "Central functions of the lumenal and peripheral thylakoid proteome of
RT   Arabidopsis determined by experimentation and genome-wide prediction.";
RL   Plant Cell 14:211-236(2002).
RN   [8]
RP   GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Columbia;
RX   PubMed=15047905; DOI=10.1104/pp.103.031005;
RA   He Z., Li L., Luan S.;
RT   "Immunophilins and parvulins. Superfamily of peptidyl prolyl isomerases in
RT   Arabidopsis.";
RL   Plant Physiol. 134:1248-1267(2004).
RN   [9]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE
RP   ANALYSIS].
RX   PubMed=18431481; DOI=10.1371/journal.pone.0001994;
RA   Zybailov B., Rutschow H., Friso G., Rudella A., Emanuelsson O., Sun Q.,
RA   van Wijk K.J.;
RT   "Sorting signals, N-terminal modifications and abundance of the chloroplast
RT   proteome.";
RL   PLoS ONE 3:E1994-E1994(2008).
RN   [10]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22092075; DOI=10.1021/pr200917t;
RA   Aryal U.K., Krochko J.E., Ross A.R.;
RT   "Identification of phosphoproteins in Arabidopsis thaliana leaves using
RT   polyethylene glycol fractionation, immobilized metal-ion affinity
RT   chromatography, two-dimensional gel electrophoresis and mass
RT   spectrometry.";
RL   J. Proteome Res. 11:425-437(2012).
CC   -!- FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the
CC       cis-trans isomerization of proline imidic peptide bonds in
CC       oligopeptides (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC         peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC         COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC         ChEBI:CHEBI:83834; EC=5.2.1.8;
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid lumen
CC       {ECO:0000269|PubMed:11719511, ECO:0000269|PubMed:18431481}.
CC   -!- SIMILARITY: Belongs to the FKBP-type PPIase family. {ECO:0000305}.
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DR   EMBL; AL163572; CAB87148.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED91891.1; -; Genomic_DNA.
DR   EMBL; BT012636; AAT06455.1; -; mRNA.
DR   EMBL; AK316854; BAH19563.1; -; mRNA.
DR   EMBL; AK175218; BAD42981.1; -; mRNA.
DR   PIR; T48588; T48588.
DR   RefSeq; NP_196845.1; NM_121344.6.
DR   AlphaFoldDB; Q9LYR5; -.
DR   SMR; Q9LYR5; -.
DR   STRING; 3702.AT5G13410.1; -.
DR   iPTMnet; Q9LYR5; -.
DR   PaxDb; Q9LYR5; -.
DR   PRIDE; Q9LYR5; -.
DR   ProteomicsDB; 228909; -.
DR   EnsemblPlants; AT5G13410.1; AT5G13410.1; AT5G13410.
DR   GeneID; 831182; -.
DR   Gramene; AT5G13410.1; AT5G13410.1; AT5G13410.
DR   KEGG; ath:AT5G13410; -.
DR   Araport; AT5G13410; -.
DR   TAIR; locus:2181660; AT5G13410.
DR   eggNOG; KOG0552; Eukaryota.
DR   HOGENOM; CLU_090815_0_0_1; -.
DR   InParanoid; Q9LYR5; -.
DR   OMA; FPDYTET; -.
DR   OrthoDB; 1601308at2759; -.
DR   PhylomeDB; Q9LYR5; -.
DR   PRO; PR:Q9LYR5; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9LYR5; baseline and differential.
DR   Genevisible; Q9LYR5; AT.
DR   GO; GO:0009507; C:chloroplast; HDA:TAIR.
DR   GO; GO:0009543; C:chloroplast thylakoid lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0009535; C:chloroplast thylakoid membrane; HDA:TAIR.
DR   GO; GO:0009579; C:thylakoid; HDA:TAIR.
DR   GO; GO:0031977; C:thylakoid lumen; HDA:TAIR.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.50.40; -; 1.
DR   InterPro; IPR044208; FKBP19-like.
DR   InterPro; IPR046357; PPIase_dom_sf.
DR   InterPro; IPR001179; PPIase_FKBP_dom.
DR   PANTHER; PTHR47717; PTHR47717; 1.
DR   Pfam; PF00254; FKBP_C; 1.
DR   PROSITE; PS50059; FKBP_PPIASE; 1.
PE   1: Evidence at protein level;
KW   Chloroplast; Direct protein sequencing; Isomerase; Phosphoprotein; Plastid;
KW   Reference proteome; Rotamase; Thylakoid; Transit peptide.
FT   TRANSIT         1..29
FT                   /note="Chloroplast"
FT                   /evidence="ECO:0000255"
FT   TRANSIT         30..88
FT                   /note="Thylakoid"
FT                   /evidence="ECO:0000269|PubMed:11719511,
FT                   ECO:0000269|PubMed:11826309"
FT   CHAIN           89..256
FT                   /note="Peptidyl-prolyl cis-trans isomerase FKBP19,
FT                   chloroplastic"
FT                   /id="PRO_0000342098"
FT   DOMAIN          135..254
FT                   /note="PPIase FKBP-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00277"
FT   MOD_RES         164
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22092075"
FT   CONFLICT        46
FT                   /note="S -> SVLKT (in Ref. 5; BAD42981)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   256 AA;  27778 MW;  30CBBE141BDDB8A0 CRC64;
     MASISSFGCF PQSTALAGTS STTRCRTTVA ARLADQSDDF APLRSSGGNC GCVNNSGEFD
     RRKLLVSSVG LLIGALSYDS KDGDFASASQ FADMPALKGK DYGKTKMKYP DYTETQSGLQ
     YKDLRVGTGP IAKKGDKVVV DWDGYTIGYY GRIFEARNKT KGGSFEGDDK EFFKFTLGSN
     EVIPAFEEAV SGMALGGIRR IIVPPELGYP DNDYNKSGPR PMTFSGQRAL DFVLRNQGLI
     DKTLLFDVEL LKIVPN
 
 
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