AKND1_MACFA
ID AKND1_MACFA Reviewed; 759 AA.
AC Q8WP21; Q95JZ6; Q95LM8;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 40.
DE RecName: Full=Protein AKNAD1;
GN Name=AKNAD1; ORFNames=QtsA-11775, QtsA-19735, QtsA-21583;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Testis;
RX PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA Terao K., Sugano S., Hashimoto K.;
RT "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT the human genome sequence.";
RL BMC Genomics 3:36-36(2002).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8WP21-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WP21-2; Sequence=VSP_034466, VSP_034467;
CC Name=3;
CC IsoId=Q8WP21-3; Sequence=VSP_034465, VSP_034468;
CC -!- SIMILARITY: Belongs to the AKNA family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB62976.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AB070031; BAB62976.1; ALT_FRAME; mRNA.
DR EMBL; AB072760; BAB69729.1; -; mRNA.
DR EMBL; AB074456; BAB72087.1; -; mRNA.
DR AlphaFoldDB; Q8WP21; -.
DR SMR; Q8WP21; -.
DR STRING; 9541.XP_005542559.1; -.
DR eggNOG; ENOG502RZDD; Eukaryota.
DR Proteomes; UP000233100; Unplaced.
DR InterPro; IPR022150; AKNA_dom.
DR Pfam; PF12443; AKNA; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..759
FT /note="Protein AKNAD1"
FT /id="PRO_0000342471"
FT REGION 169..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 678..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 735..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 371..482
FT /evidence="ECO:0000255"
FT COMPBIAS 178..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..654
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 511..540
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12498619"
FT /id="VSP_034465"
FT VAR_SEQ 554
FT /note="I -> MRTPGALQEGRIVQRRRHPVPAVPSVAGSLNGSQKWRKRATEGSTVE
FT DFQLSMKRHHIQIPLPILIQDTASVLILALKCRVTNVRTVALRFLPPEEPAERNHLKNF
FT IIDTTLQERITQIIAKEVPLSSPILYMKAKTLHPVSTSPA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12498619"
FT /id="VSP_034466"
FT VAR_SEQ 555..759
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12498619"
FT /id="VSP_034467"
FT VAR_SEQ 721..730
FT /note="SLASPFCCPG -> C (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12498619"
FT /id="VSP_034468"
FT CONFLICT 114
FT /note="L -> F (in Ref. 1; BAB62976)"
FT /evidence="ECO:0000305"
FT CONFLICT 234
FT /note="P -> Q (in Ref. 1; BAB62976/BAB69729)"
FT /evidence="ECO:0000305"
FT CONFLICT 395
FT /note="R -> Q (in Ref. 1; BAB62976/BAB69729)"
FT /evidence="ECO:0000305"
FT CONFLICT 472
FT /note="L -> P (in Ref. 1; BAB62976)"
FT /evidence="ECO:0000305"
FT CONFLICT 479
FT /note="V -> M (in Ref. 1; BAB62976/BAB69729)"
FT /evidence="ECO:0000305"
FT CONFLICT 690
FT /note="H -> Y (in Ref. 1; BAB62976)"
FT /evidence="ECO:0000305"
FT CONFLICT 708
FT /note="R -> Q (in Ref. 1; BAB62976)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 759 AA; 84095 MW; 04EF935817C86B28 CRC64;
MDEADFSEDT TYKQEDLPYD GDLSPIKICN DYSFTSKNDA FEVSSQIIFI ADDPQEKAMH
NETCGNTAMT MPLGKTTENA ANKKDEKEKQ CTAALHIPAN EGDASKSSIS DILLHHLSKE
PFLRGQGIDC ETLPEISNAD SFEEEAIIKS IISCCNKNSW PKEQTLELTD QLNPKKDGEN
SNKPGSPTMT EENTSDLEET VAAGDSSHQE NVNILTKTKG PGDKQNSYQG QAPPKQHTEK
ASSGNRFKYG QGQVHYQLPD FSKIAPEVKN PKNNIINKPL AIAKQVSFSK LREKPAVVQD
ILETMPESNC VEKQHQEQKG EITEPSQQIQ MEPTVHIHQE LLTGIESEAS ISKLSPTSQK
GTSSSSSYIF QKISQGKQMC QKLKEQTDQL KTKVREFSKR IKQESPYHLQ DKKLVLEKLQ
GHLELLEQNF LATKDKHLTL QQQVHKHEST IVSDFDPERK VEGEIFKLEM LLEDVKDKVD
ESKYTSAPSL PVSSPVTLDD LASTSSSLSN EVPEEHPGHP PGPRGSGGSE ATGTPQGGPQ
EAPKEELCEL TPQIYLNGHY GDATVQNQPD QVAMRLSSNS GEDPRCTPGR QDCAETTAPS
PSCAFCRRLL EWKPKVEKKG HRRIHCGRFS TVHEKAPHSD STPNSDTGHS FCSDSGTEMQ
GNKCQDCGTK IPTSRRACRK EPPKEFHYRH NTPGENYSNH SKRGAFVRPH SLHESKNSSP
SLASPFCCPG LMYSPDTSKS SPTPGWQEAE LGLENMKSQ
