FKBP3_RABIT
ID FKBP3_RABIT Reviewed; 224 AA.
AC O46638;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP3;
DE Short=PPIase FKBP3;
DE EC=5.2.1.8;
DE AltName: Full=25 kDa FK506-binding protein;
DE Short=25 kDa FKBP;
DE Short=FKBP-25;
DE AltName: Full=FK506-binding protein 3;
DE Short=FKBP-3;
DE AltName: Full=Immunophilin FKBP25;
DE AltName: Full=Rapamycin-selective 25 kDa immunophilin;
DE AltName: Full=Rotamase;
GN Name=FKBP3; Synonyms=FKBP25;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 2-224.
RC TISSUE=Cornea;
RX PubMed=8876379;
RA Kitagawa H., Hotta Y., Fujiki K., Kanai A.;
RT "Cloning and high expression of rabbit FKBP25 in cornea.";
RL Jpn. J. Ophthalmol. 40:133-141(1996).
CC -!- FUNCTION: FK506- and rapamycin-binding proteins (FKBPs) constitute a
CC family of receptors for the two immunosuppressants which inhibit T-cell
CC proliferation by arresting two distinct cytoplasmic signal transmission
CC pathways. PPIases accelerate the folding of proteins (By similarity).
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC ChEBI:CHEBI:83834; EC=5.2.1.8;
CC -!- ACTIVITY REGULATION: Inhibited preferentially by rapamycin over FK506.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the FKBP-type PPIase family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; D82876; BAA24412.1; -; mRNA.
DR RefSeq; XP_002718212.1; XM_002718166.3.
DR AlphaFoldDB; O46638; -.
DR BMRB; O46638; -.
DR SMR; O46638; -.
DR STRING; 9986.ENSOCUP00000006516; -.
DR GeneID; 100009004; -.
DR KEGG; ocu:100009004; -.
DR CTD; 2287; -.
DR eggNOG; KOG0544; Eukaryota.
DR HOGENOM; CLU_013615_12_2_1; -.
DR InParanoid; O46638; -.
DR OMA; FKGTEPV; -.
DR OrthoDB; 1328688at2759; -.
DR TreeFam; TF105293; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.10.50.40; -; 1.
DR InterPro; IPR043368; FKBP3.
DR InterPro; IPR041200; FKBP3_BTHB.
DR InterPro; IPR046357; PPIase_dom_sf.
DR InterPro; IPR001179; PPIase_FKBP_dom.
DR PANTHER; PTHR46493; PTHR46493; 1.
DR Pfam; PF18410; BTHB; 1.
DR Pfam; PF00254; FKBP_C; 1.
DR PROSITE; PS50059; FKBP_PPIASE; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Isomerase; Nucleus; Phosphoprotein; Reference proteome;
KW Rotamase.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q00688"
FT CHAIN 2..224
FT /note="Peptidyl-prolyl cis-trans isomerase FKBP3"
FT /id="PRO_0000075309"
FT DOMAIN 128..224
FT /note="PPIase FKBP-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00277"
FT REGION 87..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q00688"
FT MOD_RES 36
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00688"
FT MOD_RES 99
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q62446"
FT MOD_RES 152
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q00688"
FT MOD_RES 170
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q00688"
SQ SEQUENCE 224 AA; 25188 MW; 9E6E54AACB0E079D CRC64;
MAAAVPQRAW TVEQLRSEQL PKKDIIKFLQ DHGSDSFLAE HKLLGNIKNV AKTANKDHLV
TAYNHLFETK RFKGSENVTK VSEQVKNVKL NEDKPKETKS EETPDEGPPK YTKSVLKKGD
KTNFPKKGDV VHCWYTGTLQ DGTVFDTNIQ TSSKKKKNAK PLSFKVGVGK VIRGWDEALL
TMSKGEKARL EIEPEWAYGK KGQPDAKIPP NAKLIFEVEL VDID
