ID   FKBP6_BOVIN             Reviewed;         326 AA.
AC   A6QQ71;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Inactive peptidyl-prolyl cis-trans isomerase FKBP6;
DE            Short=Inactive PPIase FKBP6;
DE   AltName: Full=36 kDa FK506-binding protein;
DE   AltName: Full=FK506-binding protein 6;
DE            Short=FKBP-6;
DE   AltName: Full=Immunophilin FKBP36;
GN   Name=FKBP6; Synonyms=FKBP36;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Co-chaperone required during spermatogenesis to repress
CC       transposable elements and prevent their mobilization, which is
CC       essential for the germline integrity. Acts via the piRNA metabolic
CC       process, which mediates the repression of transposable elements during
CC       meiosis by forming complexes composed of piRNAs and Piwi proteins and
CC       govern the methylation and subsequent repression of transposons. Acts
CC       as a co-chaperone via its interaction with HSP90 and is required for
CC       the piRNA amplification process, the secondary piRNA biogenesis. May be
CC       required together with HSP90 in removal of 16 nucleotide ping-pong by-
CC       products from Piwi complexes, possibly facilitating turnover of Piwi
CC       complexes (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with HSP72/HSPA2 and CLTC. Interacts with GAPDH;
CC       leading to inhibit GAPDH catalytic activity. Interacts (via TPR
CC       repeats) with HSP90 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Chromosome {ECO:0000250}. Note=Does not localize to pi-
CC       bodies. Localizes to meiotic chromosome cores and regions of homologous
CC       chromosome synapsis (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FKBP6 family. {ECO:0000305}.
CC   -!- CAUTION: Although it contains a PPIase FKBP-type domain, does not show
CC       peptidyl-prolyl cis-trans isomerase activity. {ECO:0000305}.
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DR   EMBL; BC149679; AAI49680.1; -; mRNA.
DR   RefSeq; NP_001095679.1; NM_001102209.1.
DR   AlphaFoldDB; A6QQ71; -.
DR   SMR; A6QQ71; -.
DR   STRING; 9913.ENSBTAP00000002909; -.
DR   PaxDb; A6QQ71; -.
DR   PRIDE; A6QQ71; -.
DR   Ensembl; ENSBTAT00000002909; ENSBTAP00000002909; ENSBTAG00000002253.
DR   GeneID; 537921; -.
DR   KEGG; bta:537921; -.
DR   CTD; 8468; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002253; -.
DR   VGNC; VGNC:29025; FKBP6.
DR   eggNOG; KOG0543; Eukaryota.
DR   GeneTree; ENSGT00940000158514; -.
DR   HOGENOM; CLU_013615_13_2_1; -.
DR   InParanoid; A6QQ71; -.
DR   OMA; GCPPRIK; -.
DR   OrthoDB; 1465346at2759; -.
DR   TreeFam; TF354214; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000002253; Expressed in spermatocyte and 49 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0000795; C:synaptonemal complex; ISS:UniProtKB.
DR   GO; GO:0051879; F:Hsp90 protein binding; ISS:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0043046; P:DNA methylation involved in gamete generation; ISS:UniProtKB.
DR   GO; GO:0031047; P:gene silencing by RNA; ISS:UniProtKB.
DR   GO; GO:0051321; P:meiotic cell cycle; ISS:UniProtKB.
DR   GO; GO:0034587; P:piRNA metabolic process; ISS:UniProtKB.
DR   GO; GO:0045070; P:positive regulation of viral genome replication; IEA:Ensembl.
DR   GO; GO:0006457; P:protein folding; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 3.10.50.40; -; 1.
DR   InterPro; IPR042282; FKBP6/shu.
DR   InterPro; IPR046357; PPIase_dom_sf.
DR   InterPro; IPR001179; PPIase_FKBP_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR46674; PTHR46674; 1.
DR   Pfam; PF00254; FKBP_C; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50059; FKBP_PPIASE; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Cytoplasm; Differentiation; Meiosis; Nucleus;
KW   Reference proteome; Repeat; RNA-mediated gene silencing; Spermatogenesis;
KW   TPR repeat.
FT   CHAIN           1..326
FT                   /note="Inactive peptidyl-prolyl cis-trans isomerase FKBP6"
FT                   /id="PRO_0000318699"
FT   DOMAIN          53..142
FT                   /note="PPIase FKBP-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00277"
FT   REPEAT          170..203
FT                   /note="TPR 1"
FT   REPEAT          218..251
FT                   /note="TPR 2"
FT   REPEAT          252..285
FT                   /note="TPR 3"
SQ   SEQUENCE   326 AA;  37611 MW;  67420C6AF848FCBB CRC64;
     MSSSRPLNGL SRLDAEDRSP YQRLSQRMLD ISGDRGVLKD VIREGAGELV TPDASVLVKY
     SGYLEHMDKP FDSNCFRKTP RLMKLGEDIT LWGMELGLLS MRRGELARFL FKPTYAYGTL
     GCPPLIPPNT TVLFEIELLD FLDSAESDKF CALSAEQQSQ FPLQKVLKVA ATEREFGNYL
     FRQNRFYDAK VRYKRALLLL HRRTAPPEEQ HLVETAKLLV FLNLSFTYLK LERPTMALRY
     GEQALIIDRK NAKALFRCGQ ACLLMTEYQK ARDFLVRAQR EQPFNHDINN ELKKLASYYR
     DYMDKEREMC HRMFASGDNG STVGEN