FKBPL_HUMAN
ID FKBPL_HUMAN Reviewed; 349 AA.
AC Q9UIM3; A8K5V3; B0UYX8; Q9H5G3;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=FK506-binding protein-like;
DE AltName: Full=WAF-1/CIP1 stabilizing protein 39;
DE Short=WISp39;
GN Name=FKBPL; Synonyms=DIR1, NG7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Lung;
RX PubMed=10521921; DOI=10.2307/3580140;
RA Robson T., Joiner M.C., Wilson G.D., McCullough W., Price M.E., Logan I.,
RA Jones H., McKeown S.R., Hirst D.G.;
RT "A novel human stress response-related gene with a potential role in
RT induced radioresistance.";
RL Radiat. Res. 152:451-461(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14656967; DOI=10.1101/gr.1736803;
RA Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D.,
RA Hood L.;
RT "Analysis of the gene-dense major histocompatibility complex class III
RT region and its comparison to mouse.";
RL Genome Res. 13:2621-2636(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT THR-90.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung, and Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-203.
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-287 AND ARG-291, AND
RP INTERACTION WITH CDKN1A AND HSP90AB1.
RX PubMed=15664193; DOI=10.1016/j.molcel.2004.11.049;
RA Jascur T., Brickner H., Salles-Passador I., Barbier V., El Khissiin A.,
RA Smith B., Fotedar R., Fotedar A.;
RT "Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR
RT protein.";
RL Mol. Cell 17:237-249(2005).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-3, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: May be involved in response to X-ray. Regulates p21 protein
CC stability by binding to Hsp90 and p21. {ECO:0000269|PubMed:15664193}.
CC -!- SUBUNIT: Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90.
CC -!- INTERACTION:
CC Q9UIM3; Q8WVL7: ANKRD49; NbExp=6; IntAct=EBI-719882, EBI-9381820;
CC Q9UIM3; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-719882, EBI-739580;
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed with higher levels in
CC testis. {ECO:0000269|PubMed:15664193}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB15663.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAG33655.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF139374; AAF67785.1; -; Genomic_DNA.
DR EMBL; AK027119; BAB15663.1; ALT_FRAME; mRNA.
DR EMBL; AK291418; BAF84107.1; -; mRNA.
DR EMBL; U89337; AAF04864.1; -; Genomic_DNA.
DR EMBL; AL662828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR753803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR925796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03586.1; -; Genomic_DNA.
DR EMBL; BC004168; AAH04168.1; -; mRNA.
DR EMBL; BC011966; AAH11966.1; -; mRNA.
DR EMBL; CR457374; CAG33655.1; ALT_FRAME; mRNA.
DR CCDS; CCDS4738.1; -.
DR RefSeq; NP_071393.2; NM_022110.3.
DR AlphaFoldDB; Q9UIM3; -.
DR SMR; Q9UIM3; -.
DR BioGRID; 122007; 29.
DR CORUM; Q9UIM3; -.
DR IntAct; Q9UIM3; 66.
DR STRING; 9606.ENSP00000364298; -.
DR iPTMnet; Q9UIM3; -.
DR PhosphoSitePlus; Q9UIM3; -.
DR BioMuta; FKBPL; -.
DR DMDM; 74762773; -.
DR EPD; Q9UIM3; -.
DR jPOST; Q9UIM3; -.
DR MassIVE; Q9UIM3; -.
DR MaxQB; Q9UIM3; -.
DR PaxDb; Q9UIM3; -.
DR PeptideAtlas; Q9UIM3; -.
DR PRIDE; Q9UIM3; -.
DR ProteomicsDB; 84550; -.
DR Antibodypedia; 28379; 291 antibodies from 29 providers.
DR DNASU; 63943; -.
DR Ensembl; ENST00000375156.4; ENSP00000364298.3; ENSG00000204315.4.
DR Ensembl; ENST00000425378.2; ENSP00000397530.2; ENSG00000230907.2.
DR Ensembl; ENST00000443350.2; ENSP00000398812.2; ENSG00000223666.2.
DR Ensembl; ENST00000456854.2; ENSP00000412439.2; ENSG00000224200.2.
DR GeneID; 63943; -.
DR KEGG; hsa:63943; -.
DR MANE-Select; ENST00000375156.4; ENSP00000364298.3; NM_022110.4; NP_071393.2.
DR UCSC; uc003nzr.4; human.
DR CTD; 63943; -.
DR DisGeNET; 63943; -.
DR GeneCards; FKBPL; -.
DR HGNC; HGNC:13949; FKBPL.
DR HPA; ENSG00000204315; Low tissue specificity.
DR neXtProt; NX_Q9UIM3; -.
DR OpenTargets; ENSG00000204315; -.
DR PharmGKB; PA28167; -.
DR VEuPathDB; HostDB:ENSG00000204315; -.
DR eggNOG; KOG1124; Eukaryota.
DR GeneTree; ENSGT00920000149187; -.
DR HOGENOM; CLU_013615_13_0_1; -.
DR InParanoid; Q9UIM3; -.
DR OMA; AAQNCDR; -.
DR OrthoDB; 1086902at2759; -.
DR PhylomeDB; Q9UIM3; -.
DR TreeFam; TF105297; -.
DR PathwayCommons; Q9UIM3; -.
DR Reactome; R-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint.
DR SignaLink; Q9UIM3; -.
DR BioGRID-ORCS; 63943; 131 hits in 1079 CRISPR screens.
DR ChiTaRS; FKBPL; human.
DR GeneWiki; FKBPL; -.
DR GenomeRNAi; 63943; -.
DR Pharos; Q9UIM3; Tbio.
DR PRO; PR:Q9UIM3; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9UIM3; protein.
DR Bgee; ENSG00000204315; Expressed in lower esophagus mucosa and 98 other tissues.
DR ExpressionAtlas; Q9UIM3; baseline and differential.
DR Genevisible; Q9UIM3; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005576; C:extracellular region; IDA:MGI.
DR GO; GO:1905553; P:regulation of blood vessel branching; IEA:Ensembl.
DR GO; GO:0009314; P:response to radiation; NAS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF00515; TPR_1; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 2.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..349
FT /note="FK506-binding protein-like"
FT /id="PRO_0000289878"
FT REPEAT 210..243
FT /note="TPR 1"
FT REPEAT 252..285
FT /note="TPR 2"
FT REPEAT 286..319
FT /note="TPR 3"
FT REGION 36..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 3
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VARIANT 90
FT /note="A -> T (in dbSNP:rs28732176)"
FT /evidence="ECO:0000269|PubMed:14574404"
FT /id="VAR_061546"
FT MUTAGEN 287
FT /note="K->A: Abolishes HSP90AB1 binding; when associated
FT with A-291."
FT /evidence="ECO:0000269|PubMed:15664193"
FT MUTAGEN 291
FT /note="R->A: Abolishes HSP90AB1 binding; when associated
FT with A-287."
FT /evidence="ECO:0000269|PubMed:15664193"
FT CONFLICT 203
FT /note="T -> I (in Ref. 7; CAG33655)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 349 AA; 38176 MW; 428EDD70FD9C807C CRC64;
METPPVNTIG EKDTSQPQQE WEKNLRENLD SVIQIRQQPR DPPTETLELE VSPDPASQIL
EHTQGAEKLV AELEGDSHKS HGSTSQMPEA LQASDLWYCP DGSFVKKIVI RGHGLDKPKL
GSCCRVLALG FPFGSGPPEG WTELTMGVGP WREETWGELI EKCLESMCQG EEAELQLPGH
SGPPVRLTLA SFTQGRDSWE LETSEKEALA REERARGTEL FRAGNPEGAA RCYGRALRLL
LTLPPPGPPE RTVLHANLAA CQLLLGQPQL AAQSCDRVLE REPGHLKALY RRGVAQAALG
NLEKATADLK KVLAIDPKNR AAQEELGKVV IQGKNQDAGL AQGLRKMFG
