FKBPL_MOUSE
ID FKBPL_MOUSE Reviewed; 347 AA.
AC O35450; Q3UKG5;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=FK506-binding protein-like;
DE AltName: Full=WAF-1/CIP1 stabilizing protein 39;
DE Short=WISp39;
GN Name=Fkbpl; Synonyms=Ng7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=129;
RX PubMed=14656967; DOI=10.1101/gr.1736803;
RA Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D.,
RA Hood L.;
RT "Analysis of the gene-dense major histocompatibility complex class III
RT region and its comparison to mouse.";
RL Genome Res. 13:2621-2636(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in response to X-ray. Regulates p21 protein
CC stability by binding to Hsp90 and p21. {ECO:0000250}.
CC -!- SUBUNIT: Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90.
CC {ECO:0000250}.
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DR EMBL; AK146018; BAE26836.1; -; mRNA.
DR EMBL; AF030001; AAB82013.1; -; Genomic_DNA.
DR EMBL; BC046338; AAH46338.1; -; mRNA.
DR CCDS; CCDS28654.1; -.
DR PIR; T09068; T09068.
DR RefSeq; NP_063926.1; NM_019873.2.
DR RefSeq; XP_006524724.1; XM_006524661.3.
DR RefSeq; XP_006524725.1; XM_006524662.3.
DR AlphaFoldDB; O35450; -.
DR SMR; O35450; -.
DR BioGRID; 207887; 7.
DR IntAct; O35450; 1.
DR STRING; 10090.ENSMUSP00000037273; -.
DR iPTMnet; O35450; -.
DR PhosphoSitePlus; O35450; -.
DR EPD; O35450; -.
DR MaxQB; O35450; -.
DR PaxDb; O35450; -.
DR PeptideAtlas; O35450; -.
DR PRIDE; O35450; -.
DR ProteomicsDB; 267479; -.
DR Antibodypedia; 28379; 291 antibodies from 29 providers.
DR Ensembl; ENSMUST00000036720; ENSMUSP00000037273; ENSMUSG00000033739.
DR GeneID; 56299; -.
DR KEGG; mmu:56299; -.
DR UCSC; uc008cdg.1; mouse.
DR CTD; 63943; -.
DR MGI; MGI:1932127; Fkbpl.
DR VEuPathDB; HostDB:ENSMUSG00000033739; -.
DR eggNOG; KOG1124; Eukaryota.
DR GeneTree; ENSGT00920000149187; -.
DR HOGENOM; CLU_013615_13_0_1; -.
DR InParanoid; O35450; -.
DR OMA; AAQNCDR; -.
DR OrthoDB; 1086902at2759; -.
DR PhylomeDB; O35450; -.
DR TreeFam; TF105297; -.
DR Reactome; R-MMU-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint.
DR BioGRID-ORCS; 56299; 15 hits in 73 CRISPR screens.
DR PRO; PR:O35450; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; O35450; protein.
DR Bgee; ENSMUSG00000033739; Expressed in seminiferous tubule of testis and 174 other tissues.
DR ExpressionAtlas; O35450; baseline and differential.
DR Genevisible; O35450; MM.
DR GO; GO:0005576; C:extracellular region; ISO:MGI.
DR GO; GO:0045765; P:regulation of angiogenesis; IMP:MGI.
DR GO; GO:1905553; P:regulation of blood vessel branching; IMP:MGI.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF00515; TPR_1; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 2.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..347
FT /note="FK506-binding protein-like"
FT /id="PRO_0000289879"
FT REPEAT 208..241
FT /note="TPR 1"
FT REPEAT 250..283
FT /note="TPR 2"
FT REPEAT 284..317
FT /note="TPR 3"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 3
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9UIM3"
FT CONFLICT 187
FT /note="L -> M (in Ref. 1; BAE26836)"
FT /evidence="ECO:0000305"
FT CONFLICT 252
FT /note="L -> I (in Ref. 1; BAE26836)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 347 AA; 38302 MW; 33C1B20B4CC8FF83 CRC64;
METSPISPMN EKNTAQPQQR EENAQQILNT AIPFRQRSPG LLPEALKVGV RPDPANQIVE
TQEIEHPVAG FEGDSDQFQV STNEMAEHLQ ASDLWYCPDG SFVKKIIVPG HGLDKPKLGS
KCQVLALGFP FGSGMPEGWT ELTIGIGQWR EKMWGELMEK CLESMRQGEE AKIHLPGSSA
PLAKLRLDSF TNGRDSWEME AMEKEALAKE EHRRGTELFR AGNPQGAARC YGRALRLLLT
LPPPGPPERT TLYANLAACQ LLLGHPQLAA QSCDRVLERE PGHLKALYRR GVARAALGDL
EKATADFKKV LAVDPKNRAA KEELGKVVIQ GRKQDAGLAR GLRKMFS