ID   FKBPL_RAT               Reviewed;         347 AA.
AC   Q6MG81;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=FK506-binding protein-like;
DE   AltName: Full=WAF-1/CIP1 stabilizing protein 39;
DE            Short=WISp39;
GN   Name=Fkbpl;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15060004; DOI=10.1101/gr.1987704;
RA   Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H.,
RA   Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.;
RT   "The genomic sequence and comparative analysis of the rat major
RT   histocompatibility complex.";
RL   Genome Res. 14:631-639(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in response to X-ray. Regulates p21 protein
CC       stability by binding to Hsp90 and p21. {ECO:0000250}.
CC   -!- SUBUNIT: Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90.
CC       {ECO:0000250}.
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DR   EMBL; BX883044; CAE83965.1; -; Genomic_DNA.
DR   EMBL; BC086532; AAH86532.1; -; mRNA.
DR   RefSeq; NP_001002818.1; NM_001002818.2.
DR   AlphaFoldDB; Q6MG81; -.
DR   SMR; Q6MG81; -.
DR   STRING; 10116.ENSRNOP00000000494; -.
DR   PaxDb; Q6MG81; -.
DR   PRIDE; Q6MG81; -.
DR   Ensembl; ENSRNOT00000000494; ENSRNOP00000000494; ENSRNOG00000000432.
DR   GeneID; 406168; -.
DR   KEGG; rno:406168; -.
DR   UCSC; RGD:1303227; rat.
DR   CTD; 63943; -.
DR   RGD; 1303227; Fkbpl.
DR   eggNOG; KOG1124; Eukaryota.
DR   GeneTree; ENSGT00920000149187; -.
DR   HOGENOM; CLU_013615_13_0_1; -.
DR   InParanoid; Q6MG81; -.
DR   OMA; AAQNCDR; -.
DR   OrthoDB; 1086902at2759; -.
DR   PhylomeDB; Q6MG81; -.
DR   TreeFam; TF105297; -.
DR   Reactome; R-RNO-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint.
DR   PRO; PR:Q6MG81; -.
DR   Proteomes; UP000002494; Chromosome 20.
DR   Bgee; ENSRNOG00000000432; Expressed in testis and 19 other tissues.
DR   Genevisible; Q6MG81; RN.
DR   GO; GO:0005576; C:extracellular region; ISO:RGD.
DR   GO; GO:0045765; P:regulation of angiogenesis; ISO:RGD.
DR   GO; GO:1905553; P:regulation of blood vessel branching; ISO:RGD.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR001440; TPR_1.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF00515; TPR_1; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50005; TPR; 2.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..347
FT                   /note="FK506-binding protein-like"
FT                   /id="PRO_0000289880"
FT   REPEAT          208..241
FT                   /note="TPR 1"
FT   REPEAT          250..283
FT                   /note="TPR 2"
FT   REPEAT          284..317
FT                   /note="TPR 3"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..34
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         3
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UIM3"
SQ   SEQUENCE   347 AA;  37960 MW;  FC519CC9F6774C29 CRC64;
     METSLISPMK ENNTAQPQQR EENTQQNLNA AVPIKQQSPG LLPEALEVGV KPDPASQILA
     TQEIENPVAG FEGDSDKFHI STDEMAEHLQ ASDLWYCPDG SFVKKIIVHG HGLDKPKLGS
     KCRVLALGFP FGSGMPEGWT ELTIGTGQWR EKTWGELTEK CLESMRQGEE AKIHLPGSST
     PLAKLRLDSF TNGRDSWELE AVEKEALAKE EHRRGTELFR AGNPQGAARC YGRALRLLLT
     LPPPGPPERT ILHANLAACQ LLLGHPQLAA QSCDRVLERE PGHLKALYRR GVAQAALGDL
     DKATADLKKV LAVDPKNRAA KEELGKVVIQ GKIQDAGLAR GLRKMFS