ID   FKBX_ECO57              Reviewed;         149 AA.
AC   P0AEM2; P22563;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase;
DE            Short=PPIase;
DE            EC=5.2.1.8;
DE   AltName: Full=Rotamase;
GN   Name=fkpB; Synonyms=slpA; OrderedLocusNames=Z0033, ECs0031;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: PPIases accelerate the folding of proteins. Substrate
CC       specificity carried out with 'Suc-Ala-Xaa-Pro-Phe-4-nitroanilide',
CC       where Xaa is the amino acid tested, was found to be Phe > Leu >> Ile >
CC       Lys = Ala > Trp > His >> Gln (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC         peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC         COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC         ChEBI:CHEBI:83834; EC=5.2.1.8;
CC   -!- SIMILARITY: Belongs to the FKBP-type PPIase family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG54330.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33454.1; -; Genomic_DNA.
DR   PIR; F85483; F85483.
DR   PIR; G90632; G90632.
DR   RefSeq; NP_308058.1; NC_002695.1.
DR   RefSeq; WP_000004655.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0AEM2; -.
DR   BMRB; P0AEM2; -.
DR   SMR; P0AEM2; -.
DR   STRING; 155864.EDL933_0027; -.
DR   EnsemblBacteria; AAG54330; AAG54330; Z0033.
DR   EnsemblBacteria; BAB33454; BAB33454; ECs_0031.
DR   GeneID; 67416103; -.
DR   GeneID; 913427; -.
DR   KEGG; ece:Z0033; -.
DR   KEGG; ecs:ECs_0031; -.
DR   PATRIC; fig|386585.9.peg.126; -.
DR   eggNOG; COG1047; Bacteria.
DR   HOGENOM; CLU_098197_3_0_6; -.
DR   OMA; FGQTEDH; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.50.40; -; 1.
DR   InterPro; IPR046357; PPIase_dom_sf.
DR   InterPro; IPR001179; PPIase_FKBP_dom.
DR   Pfam; PF00254; FKBP_C; 1.
DR   PROSITE; PS50059; FKBP_PPIASE; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome; Rotamase.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..149
FT                   /note="FKBP-type 16 kDa peptidyl-prolyl cis-trans
FT                   isomerase"
FT                   /id="PRO_0000075370"
FT   DOMAIN          2..72
FT                   /note="PPIase FKBP-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00277"
SQ   SEQUENCE   149 AA;  16081 MW;  485CB0472D571A6F CRC64;
     MSESVQSNSA VLVHFTLKLD DGTTAESTRN NGKPALFRLG DASLSEGLEQ HLLGLKVGDK
     TTFSLEPDAA FGVPSPDLIQ YFSRREFMDA GEPEIGAIML FTAMDGSEMP GVIREINGDS
     ITVDFNHPLA GQTVHFDIEV LEIDPALEA