FKBZ_PSEAE
ID FKBZ_PSEAE Reviewed; 227 AA.
AC P30417; Q9HTU0;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2001, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Probable FKBP-type 25 kDa peptidyl-prolyl cis-trans isomerase;
DE Short=PPIase;
DE EC=5.2.1.8;
DE AltName: Full=Rotamase;
GN Name=fkl; OrderedLocusNames=PA5254;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2514124; DOI=10.1016/0378-1119(89)90136-4;
RA Kato J., Chu L., Kitano K., Devault J.D., Kimbara K., Chakrabarty A.M.,
RA Misra T.K.;
RT "Nucleotide sequence of a regulatory region controlling alginate synthesis
RT in Pseudomonas aeruginosa: characterization of the algR2 gene.";
RL Gene 84:31-38(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=PAO / PA02003;
RX PubMed=2110144; DOI=10.1128/jb.172.5.2511-2520.1990;
RA Konyecsni W.M., Deretic V.;
RT "DNA sequence and expression analysis of algP and algQ, components of the
RT multigene system transcriptionally regulating mucoidy in Pseudomonas
RT aeruginosa: algP contains multiple direct repeats.";
RL J. Bacteriol. 172:2511-2520(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
RN [4]
RP IDENTIFICATION.
RA Deretic V.;
RL Submitted (AUG-1993) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: PPIases accelerate the folding of proteins.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC ChEBI:CHEBI:83834; EC=5.2.1.8;
CC -!- SIMILARITY: Belongs to the FKBP-type PPIase family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-19 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG08639.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; M30145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M32077; AAA72067.1; ALT_SEQ; Unassigned_DNA.
DR EMBL; AE004091; AAG08639.1; ALT_INIT; Genomic_DNA.
DR PIR; D82988; D82988.
DR PIR; JQ0140; JQ0140.
DR RefSeq; NP_253941.1; NC_002516.2.
DR AlphaFoldDB; P30417; -.
DR SMR; P30417; -.
DR STRING; 287.DR97_2625; -.
DR PaxDb; P30417; -.
DR PRIDE; P30417; -.
DR EnsemblBacteria; AAG08639; AAG08639; PA5254.
DR GeneID; 880807; -.
DR KEGG; pae:PA5254; -.
DR PATRIC; fig|208964.12.peg.5507; -.
DR PseudoCAP; PA5254; -.
DR HOGENOM; CLU_013615_0_3_6; -.
DR InParanoid; P30417; -.
DR OMA; DSVIEGW; -.
DR PhylomeDB; P30417; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:GO_Central.
DR GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR Gene3D; 1.10.287.460; -; 1.
DR Gene3D; 3.10.50.40; -; 1.
DR InterPro; IPR046357; PPIase_dom_sf.
DR InterPro; IPR001179; PPIase_FKBP_dom.
DR InterPro; IPR000774; PPIase_FKBP_N.
DR InterPro; IPR036944; PPIase_FKBP_N_sf.
DR Pfam; PF00254; FKBP_C; 1.
DR Pfam; PF01346; FKBP_N; 1.
DR PROSITE; PS50059; FKBP_PPIASE; 1.
PE 3: Inferred from homology;
KW Isomerase; Reference proteome; Rotamase.
FT CHAIN 1..227
FT /note="Probable FKBP-type 25 kDa peptidyl-prolyl cis-trans
FT isomerase"
FT /id="PRO_0000075375"
FT DOMAIN 144..227
FT /note="PPIase FKBP-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00277"
FT CONFLICT 53
FT /note="M -> T (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 61
FT /note="G -> D (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 104
FT /note="T -> I (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 227 AA; 25278 MW; 305E72B4B9B3AEE5 CRC64;
MLQATCARIA RRFVWRNRMP RRLFIGLFLL PLPLFAAPPK DELAYAVGAR LGMRLQQEMP
GLELSELLLG LRQAYRGEAL EIPPERIEQL LLQHENATTE TPRTTPAEAR FLANEKARFG
VRELTGGVLV SELRRGQGNG IGAATQVHVR YRGLLADGQV FDQSESAEWF ALDSVIEGWR
TALRAMPVGA RWRVVIPSAQ AYGHEGAGDL IPPDAPLVFE IDLLGFR
