FKH02_CAEBR
ID FKH02_CAEBR Reviewed; 279 AA.
AC A8XJN7;
DT 25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Forkhead box protein fkh-2 {ECO:0000305};
DE AltName: Full=Forkhead transcription factor family member fkh-2 {ECO:0000312|WormBase:CBG14280};
GN Name=fkh-2 {ECO:0000312|WormBase:CBG14280};
GN Synonyms=Cbr-fkh-2 {ECO:0000312|WormBase:CBG14280};
GN ORFNames=CBG14280 {ECO:0000312|WormBase:CBG14280};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000312|Proteomes:UP000008549};
RN [1] {ECO:0000312|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000312|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
RN [2] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=11044397; DOI=10.1242/dev.127.22.4825;
RA Molin L., Mounsey A., Aslam S., Bauer P., Young J., James M.,
RA Sharma-Oates A., Hope I.A.;
RT "Evolutionary conservation of redundancy between a diverged pair of
RT forkhead transcription factor homologues.";
RL Development 127:4825-4835(2000).
CC -!- FUNCTION: Transcription factor (By similarity). Plays a role in
CC embryogenesis and later development, perhaps acting redundantly with
CC forkhead protein pes-1 (PubMed:11044397).
CC {ECO:0000250|UniProtKB:Q12952, ECO:0000269|PubMed:11044397}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q22510,
CC ECO:0000255|PROSITE-ProRule:PRU00089}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown by injection into adults
CC causes almost half of their progeny to terminally arrest at the larval
CC L1 stage and the rest developed into fertile adults (PubMed:11044397).
CC Simultaneous knockdown of forkhead gene pes-1 causes 8% embryonic
CC lethality and 80% of progeny to arrest at larval L1 stage
CC (PubMed:11044397). {ECO:0000269|PubMed:11044397}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; HE600983; CAP32863.1; -; Genomic_DNA.
DR RefSeq; XP_002644424.1; XM_002644378.1.
DR STRING; 6238.CBG14280; -.
DR EnsemblMetazoa; CBG14280.1; CBG14280.1; WBGene00034833.
DR GeneID; 8586420; -.
DR KEGG; cbr:CBG_14280; -.
DR CTD; 8586420; -.
DR WormBase; CBG14280; CBP03597; WBGene00034833; Cbr-fkh-2.
DR eggNOG; KOG2294; Eukaryota.
DR HOGENOM; CLU_1070538_0_0_1; -.
DR InParanoid; A8XJN7; -.
DR OMA; KDSKSPC; -.
DR OrthoDB; 1270467at2759; -.
DR Proteomes; UP000008549; Chromosome X.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0016358; P:dendrite development; IEA:EnsemblMetazoa.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IEA:EnsemblMetazoa.
DR GO; GO:0002119; P:nematode larval development; IEA:EnsemblMetazoa.
DR GO; GO:0048665; P:neuron fate specification; IEA:EnsemblMetazoa.
DR GO; GO:1905515; P:non-motile cilium assembly; IEA:EnsemblMetazoa.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 3: Inferred from homology;
KW DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..279
FT /note="Forkhead box protein fkh-2"
FT /id="PRO_0000455282"
FT DNA_BIND 101..196
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 42..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 279 AA; 31322 MW; 0C926B95AD122D9B CRC64;
MARFSILDLC PDLVEKAMNV QNGLVSMQST LQLQAQKDIN DPCTSIDSTT DIMSNPANDN
SDYLLDESVD DERSESTSSK DSKSPCSNSS DDKKPSSPND KPPFSYNALI MMAIKNSPEK
RLTLAGIYDY ILTNYPFYRD NKQGWQNSIR HNLSLNKCFV KVPRNFDDPG KGNYWMLDAT
CEDEVFIGGA TGKLRRRPST LSRARMDAYK QYGAAAANLF PYFNPGLPPM PRTPFITTPP
TAFLPRPMMP MPSLAPVFTQ PELIQMYLNQ QQGLFAKLQ
