FKH2_CANAL
ID FKH2_CANAL Reviewed; 687 AA.
AC Q5A7S7; A0A1D8PJ14;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2017, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Fork-head transcriptional regulator 2;
GN Name=FKH2; Synonyms=FKH1; OrderedLocusNames=CAALFM_C300670CA;
GN ORFNames=CaO19.12844, CaO19.5389;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=12455696; DOI=10.1128/ec.1.5.787-798.2002;
RA Bensen E.S., Filler S.G., Berman J.;
RT "A forkhead transcription factor is important for true hyphal as well as
RT yeast morphogenesis in Candida albicans.";
RL Eukaryot. Cell 1:787-798(2002).
RN [5]
RP INDUCTION.
RX PubMed=16710830; DOI=10.1002/yea.1373;
RA Umeyama T., Kaneko A., Niimi M., Uehara Y.;
RT "Repression of CDC28 reduces the expression of the morphology-related
RT transcription factors, Efg1p, Nrg1p, Rbf1p, Rim101p, Fkh2p and Tec1p and
RT induces cell elongation in Candida albicans.";
RL Yeast 23:537-552(2006).
RN [6]
RP INDUCTION.
RX PubMed=17645752; DOI=10.1111/j.1462-5822.2007.01009.x;
RA Zakikhany K., Naglik J.R., Schmidt-Westhausen A., Holland G., Schaller M.,
RA Hube B.;
RT "In vivo transcript profiling of Candida albicans identifies a gene
RT essential for interepithelial dissemination.";
RL Cell. Microbiol. 9:2938-2954(2007).
CC -!- FUNCTION: Transcription factor required for the morphogenesis of true
CC hyphal as well as yeast cells. Contributes to virulence.
CC {ECO:0000269|PubMed:12455696}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- INDUCTION: Induced during host epithelium infection. Expression is
CC positively regulated by CDC28. {ECO:0000269|PubMed:16710830,
CC ECO:0000269|PubMed:17645752}.
CC -!- DISRUPTION PHENOTYPE: Forms constitutive pseudohyphae. Impairs ability
CC to damage human epithelial or human endothelial cells in vitro.
CC {ECO:0000269|PubMed:12455696}.
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DR EMBL; CP017625; AOW28117.1; -; Genomic_DNA.
DR RefSeq; XP_019330824.1; XM_019475279.1.
DR AlphaFoldDB; Q5A7S7; -.
DR SMR; Q5A7S7; -.
DR BioGRID; 1223630; 4.
DR STRING; 237561.Q5A7S7; -.
DR PRIDE; Q5A7S7; -.
DR GeneID; 3640536; -.
DR KEGG; cal:CAALFM_C300670CA; -.
DR CGD; CAL0000195461; FKH2.
DR VEuPathDB; FungiDB:C3_00670C_A; -.
DR eggNOG; KOG2294; Eukaryota.
DR HOGENOM; CLU_007090_2_0_1; -.
DR InParanoid; Q5A7S7; -.
DR OrthoDB; 1270467at2759; -.
DR PHI-base; PHI:252; -.
DR PRO; PR:Q5A7S7; -.
DR Proteomes; UP000000559; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0044182; P:filamentous growth of a population of unicellular organisms; IEA:UniProt.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProt.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR CDD; cd00060; FHA; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF49879; SSF49879; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Virulence.
FT CHAIN 1..687
FT /note="Fork-head transcriptional regulator 2"
FT /id="PRO_0000426080"
FT DOMAIN 82..146
FT /note="FHA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
FT DNA_BIND 252..350
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 584..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 663..670
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT COMPBIAS 226..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..687
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 687 AA; 76331 MW; 86CE6739E9D57785 CRC64;
MSAQFITPKK RPHSPLDSNE LLPSFEDPQD MINAVVSTLS APEEKTNVSI AYANEKNQAT
EIQAYAKIAG KDWTFYVKSL AVSIGRNIEL SAPSNTNITT PLIDIDLGPA KVVSRSHAAI
TYNLDLRCWE LKVLGRNGAR IDGQKVNVDS PNVNALHSGA ILDIGGTQMM FILPDAPAVV
APKMLEKCLL RYKEQQQQQN KRISSGPGIG GSTSFQMFDK AHLTHSPSSI SANSLQSNLD
QDLSKEEAKD IKPPYSYATM ITQAILSNPQ GVMSLSEIYN WIADHYAYYK YSKTGWQNSI
RHNLSLNKAF EKVPRRPNEP GKGMKWQISE SYKEEFLNKI SDGTISKTRR GSSVSRQLSL
HLATHNQLPE SHKYTMDQQI HNGTAASIPQ QQKQQQQQQK RPPQQQNSQP HLSQPHYTIP
SNPMQTNSMG YIPQSNIYNM SNSDRRYTPY QQSQNPLMYQ HQQQHIGQTY NQLGRPQGQL
GQPMMQPQQQ SYTSSNIKTE PSSPKRNPSI SNNTPKMAKG TVSTESHSRS TSYTTTQLHE
MSNFNSSAND STSTAPTAST TTNGDIGLNF ASPKKITALE AYTPERGSKG NPSGTNNNNN
TNNTNTNTTN NNNGKNTAGG PNTNQSSPAF WNFVQFSTPN GQSPVRKSSE EVGNNSPTLN
RKIKREREND ETNSPFKKKQ RTEMIDS
