ID   FKH3_CAEEL              Reviewed;         421 AA.
AC   A0A078BQN7; A0A078BTN3;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   29-OCT-2014, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Forkhead box protein fkh-3 {ECO:0000305};
GN   Name=fkh-3 {ECO:0000312|WormBase:C29F7.4a};
GN   ORFNames=C29F7.4 {ECO:0000312|WormBase:C29F7.4a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX   PubMed=12568714; DOI=10.1016/s0378-1119(02)01175-7;
RA   Hope I.A., Mounsey A., Bauer P., Aslam S.;
RT   "The forkhead gene family of Caenorhabditis elegans.";
RL   Gene 304:43-55(2003).
RN   [3] {ECO:0000305}
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=22819322; DOI=10.1016/j.molcel.2012.06.021;
RA   Cecere G., Zheng G.X., Mansisidor A.R., Klymko K.E., Grishok A.;
RT   "Promoters recognized by forkhead proteins exist for individual 21U-RNAs.";
RL   Mol. Cell 47:734-745(2012).
CC   -!- FUNCTION: Transcription factor (By similarity). Binds to DNA sequence
CC       motif 5'-CTGTTTCA-3' (PubMed:22819322). Regulates expression of a class
CC       of small RNAs, known as 21U-RNAs, perhaps acting redundantly with fkh-4
CC       and fkh-5 (PubMed:22819322). {ECO:0000250|UniProtKB:Q12948,
CC       ECO:0000269|PubMed:22819322}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089,
CC       ECO:0000269|PubMed:12568714}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a {ECO:0000312|WormBase:C29F7.4a};
CC         IsoId=A0A078BQN7-1; Sequence=Displayed;
CC       Name=b {ECO:0000312|WormBase:C29F7.4b};
CC         IsoId=A0A078BQN7-2; Sequence=VSP_061392;
CC   -!- DEVELOPMENTAL STAGE: Expressed in most cells of the cleavage stage
CC       embryo, apart from a few cells at the posterior pole, from the 20 cell
CC       stage to the 200 cell stage. {ECO:0000269|PubMed:12568714}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown causes significant
CC       reduction in the expression of 21U-RNAs, upon simultaneous knockdown of
CC       fkh-4 and fkh-5. {ECO:0000269|PubMed:22819322}.
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DR   EMBL; BX284606; CDX47492.1; -; Genomic_DNA.
DR   EMBL; BX284606; CDX47493.1; -; Genomic_DNA.
DR   RefSeq; NP_001294822.1; NM_001307893.1.
DR   AlphaFoldDB; A0A078BQN7; -.
DR   SMR; A0A078BQN7; -.
DR   EnsemblMetazoa; C29F7.4a.1; C29F7.4a.1; WBGene00001435. [A0A078BQN7-1]
DR   EnsemblMetazoa; C29F7.4b.1; C29F7.4b.1; WBGene00001435. [A0A078BQN7-2]
DR   GeneID; 181465; -.
DR   CTD; 181465; -.
DR   WormBase; C29F7.4a; CE50018; WBGene00001435; fkh-3.
DR   WormBase; C29F7.4b; CE50009; WBGene00001435; fkh-3.
DR   GeneTree; ENSGT00970000197133; -.
DR   OrthoDB; 912825at2759; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00001435; Expressed in embryo and 2 other tissues.
DR   ExpressionAtlas; A0A078BQN7; baseline.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:WormBase.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; DNA-binding; Nucleus; Reference proteome;
KW   Transcription.
FT   CHAIN           1..421
FT                   /note="Forkhead box protein fkh-3"
FT                   /id="PRO_0000454784"
FT   DNA_BIND        118..218
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   VAR_SEQ         33..58
FT                   /note="QYDLFDGFAEFGFLEQVPTTNMHSFS -> H (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_061392"
SQ   SEQUENCE   421 AA;  48819 MW;  50C78899D1001275 CRC64;
     MQSNDENIYF PANQYVNAGQ YSPLQQSFSQ NSQYDLFDGF AEFGFLEQVP TTNMHSFSQS
     TQMEQNCLPN VNNSTRKRKA PGQNEQATVK RRQIGIEKWR LPSRSVVQPS ADISDLRRPP
     ISYVALCALA CRNAPDMKIT PAGVYAFILH HWRYYRYANE NWKNSVRHQL SSKEHFDEET
     FQPDPSNQTV RRKFYIVKNP NMIRQNLISD ADFDFFRKDS RGIEFYQKMF AGQIGLPRSL
     FYQIIGNEIP FLAGPENSSM FYQLLGMGKV VGYLETRYFR EHYRSEHAAT EPKYEEDYAN
     FTEKIPSNAE NLMSYGAATE RNFQKFDFTD EEIELFHLNI SSYHSVQKTC KECNLPNWCT
     PSVGDVETYV FGRQVPMPVN TPVILQQFET VAEQEGIRNN PLEEQKTTKD PRDISVLEAL
     A