ID   FKH5_CAEEL              Reviewed;         461 AA.
AC   Q19802;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2013, sequence version 2.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Putative forkhead-related transcription factor fkh-5;
GN   Name=fkh-5; ORFNames=F26A1.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=12568714; DOI=10.1016/s0378-1119(02)01175-7;
RA   Hope I.A., Mounsey A., Bauer P., Aslam S.;
RT   "The forkhead gene family of Caenorhabditis elegans.";
RL   Gene 304:43-55(2003).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=22819322; DOI=10.1016/j.molcel.2012.06.021;
RA   Cecere G., Zheng G.X., Mansisidor A.R., Klymko K.E., Grishok A.;
RT   "Promoters recognized by forkhead proteins exist for individual 21U-RNAs.";
RL   Mol. Cell 47:734-745(2012).
CC   -!- FUNCTION: Transcription factor (By similarity). Binds to DNA sequence
CC       motif 5'-CTGTTTCA-3' (PubMed:22819322). Regulates expression of a class
CC       of small RNAs, known as 21U-RNAs, perhaps acting redundantly with fkh-4
CC       and fkh-3 (PubMed:22819322). {ECO:0000250|UniProtKB:Q12948,
CC       ECO:0000269|PubMed:22819322}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in most cells of the cleavage stage
CC       embryo, apart from a few cells at the posterior pole, from the 20 cell
CC       stage to the 200 cell stage (PubMed:12568714). Expressed in a few
CC       neurons in the head of young larvae (PubMed:12568714).
CC       {ECO:0000269|PubMed:12568714}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown causes significant
CC       reduction in the expression of 21U-RNAs, upon simultaneous knockdown of
CC       fkh-3 and fkh-4. {ECO:0000269|PubMed:22819322}.
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DR   EMBL; BX284603; CCD66794.2; -; Genomic_DNA.
DR   PIR; T16161; T16161.
DR   RefSeq; NP_498003.2; NM_065602.2.
DR   AlphaFoldDB; Q19802; -.
DR   SMR; Q19802; -.
DR   BioGRID; 49725; 2.
DR   STRING; 6239.F26A1.2; -.
DR   PaxDb; Q19802; -.
DR   PRIDE; Q19802; -.
DR   EnsemblMetazoa; F26A1.2.1; F26A1.2.1; WBGene00001437.
DR   GeneID; 184944; -.
DR   KEGG; cel:CELE_F26A1.2; -.
DR   UCSC; F26A1.2; c. elegans.
DR   CTD; 184944; -.
DR   WormBase; F26A1.2; CE47949; WBGene00001437; fkh-5.
DR   eggNOG; KOG2294; Eukaryota.
DR   GeneTree; ENSGT00970000197133; -.
DR   HOGENOM; CLU_696844_0_0_1; -.
DR   InParanoid; Q19802; -.
DR   OrthoDB; 912825at2759; -.
DR   PhylomeDB; Q19802; -.
DR   PRO; PR:Q19802; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00001437; Expressed in embryo and 1 other tissue.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:WormBase.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..461
FT                   /note="Putative forkhead-related transcription factor fkh-
FT                   5"
FT                   /id="PRO_0000091917"
FT   DNA_BIND        171..262
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
SQ   SEQUENCE   461 AA;  54170 MW;  24B8EDE2F8797371 CRC64;
     MQYALTVIFQ SILFVQCQVG EAAFVISQEH EVSKSISINM TLFPSIKWII HKSFYLYLTY
     FVMSQQTLPC FQAADSYNYS HSLPKVQFAR FSKYTPQSIS YSSTQMYQQK EYSDHITEMT
     NVHKSRKRKL MVTEDQWGSQ ITIPKVIQNR PLIEKWFVQK RFKMVKVRNI QRPQLSYQLL
     SALTCLNSPD GMISTTEIYS FILHHWRYYR YANENWKNSV RHVLCKCQLF DVLQVEGLSR
     KGNVYKLKRP DNVEKEMIDV KTLGCMQKDS RGIDFYIKML AGQIGLPRHL FYSIVGNEMP
     EYAGPENSAI FYHLLSMRKI IPKLETRYFL EHWQMEHKAT EPMFFEEFVP YSTSLVSCVE
     NISSYGEGVG PGNDELYDLS DRQIICFHKN IRAYHSLQKR CHKMNYSNWM TPSLIYVQEA
     VMDKEIVEDD IRNGTIECEG VARKEEAKKN FQDPALISIY N