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FL2D_XENTR
ID   FL2D_XENTR              Reviewed;         393 AA.
AC   Q6P4K5;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Pre-mRNA-splicing regulator WTAP {ECO:0000305};
DE   AltName: Full=Female-lethal(2)D homolog {ECO:0000250|UniProtKB:Q15007};
DE   AltName: Full=WT1-associated protein {ECO:0000250|UniProtKB:Q15007};
DE   AltName: Full=Wilms tumor 1-associating protein {ECO:0000250|UniProtKB:Q15007};
GN   Name=wtap {ECO:0000250|UniProtKB:Q15007};
GN   ORFNames=TEgg011e08.1 {ECO:0000303|Ref.1},
GN   TEgg064m08.1 {ECO:0000303|Ref.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Associated component of the WMM complex, a complex that
CC       mediates N6-methyladenosine (m6A) methylation of RNAs, a modification
CC       that plays a role in the efficiency of mRNA splicing and RNA
CC       processing. {ECO:0000250|UniProtKB:Q15007}.
CC   -!- SUBUNIT: Component of the WMM complex, a N6-methyltransferase complex
CC       composed of a catalytic subcomplex, named MAC, and of an associated
CC       subcomplex, named MACOM. Component of the MACOM subcomplex.
CC       {ECO:0000250|UniProtKB:Q15007}.
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q15007}.
CC       Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q15007}.
CC   -!- SIMILARITY: Belongs to the fl(2)d family. {ECO:0000305}.
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DR   EMBL; CR760675; CAJ82198.1; -; mRNA.
DR   EMBL; CR926261; CAJ81438.1; -; mRNA.
DR   EMBL; BC063362; AAH63362.1; -; mRNA.
DR   RefSeq; NP_989199.1; NM_203868.1.
DR   AlphaFoldDB; Q6P4K5; -.
DR   SMR; Q6P4K5; -.
DR   STRING; 8364.ENSXETP00000045788; -.
DR   PaxDb; Q6P4K5; -.
DR   GeneID; 394807; -.
DR   KEGG; xtr:394807; -.
DR   CTD; 9589; -.
DR   Xenbase; XB-GENE-482822; wtap.
DR   eggNOG; KOG2991; Eukaryota.
DR   InParanoid; Q6P4K5; -.
DR   OrthoDB; 907345at2759; -.
DR   Reactome; R-XTR-72203; Processing of Capped Intron-Containing Pre-mRNA.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0036396; C:RNA N6-methyladenosine methyltransferase complex; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0080009; P:mRNA methylation; ISS:UniProtKB.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR033757; WTAP.
DR   PANTHER; PTHR15217; PTHR15217; 1.
DR   Pfam; PF17098; Wtap; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Developmental protein; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..393
FT                   /note="Pre-mRNA-splicing regulator WTAP"
FT                   /id="PRO_0000308629"
FT   REGION          240..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        272..302
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        317..353
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        366..393
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   393 AA;  44312 MW;  82983BAB02EA99AE CRC64;
     MTNEEPLPKK VRLNESDFKV LPREELLQRW KQFEAYVQAL ENKYTDLNSN DVTGLRESEE
     KLKQQQQDSA RRENILVMRL ATKEQEMQEC TTQIQHLKQV QQPSVAQLRA TMVDPAINLF
     FIKMKAELEQ TKDKLEQAQN ELSAWKFTPD SQTGKKLMAK CRMLIQENQE LGRQLSQGRI
     AQLEAELALQ KKYSEELKSS QDELNDFIIQ LDEEVEGMQS TILVLQQQLK DSRQQLSQFQ
     QQIQTSGNRT PSSESKDEGE TSGKDCGRIL NGPSNGGSSH QRTHSSVGLY REGSSTEEDF
     SASPINEGKL PNHSEERTSR GGSSYMNQLS TGYESVDSPT GSENSLTHQS NDTDSNHDSQ
     EEKPVSGKGN RTVSSRHLQN GLDSSVNVQG SVL
 
 
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