FLA1_BORBU
ID FLA1_BORBU Reviewed; 336 AA.
AC P11089; O31322; P15295; Q44938;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 25-MAY-2022, entry version 147.
DE RecName: Full=Flagellar filament 41 kDa core protein;
DE Short=Flagellin;
DE AltName: Full=41 kDa antigen;
DE AltName: Full=P41;
GN Name=fla; OrderedLocusNames=BB_0147;
OS Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)
OS (Borrelia burgdorferi).
OC Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX NCBI_TaxID=224326;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF N-TERMINUS.
RC STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31, and GeHo;
RX PubMed=2726494; DOI=10.1093/nar/17.9.3590;
RA Gassmann G.S., Kramer M.D., Goebel U.B., Wallich R.;
RT "Nucleotide sequence of a gene encoding the Borrelia burgdorferi
RT flagellin.";
RL Nucleic Acids Res. 17:3590-3590(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=GeHo;
RX PubMed=1704884; DOI=10.1128/jb.173.4.1452-1459.1991;
RA Gassmann G.S., Jacobs E., Deutzmann R., Goebel U.B.;
RT "Analysis of the Borrelia burgdorferi GeHo fla gene and antigenic
RT characterization of its gene product.";
RL J. Bacteriol. 173:1452-1459(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX PubMed=2341173; DOI=10.1128/iai.58.6.1711-1719.1990;
RA Wallich R., Moter S.E., Simon M.M., Ebnet K., Heiberger A., Kramer M.D.;
RT "The Borrelia burgdorferi flagellum-associated 41-kilodalton antigen
RT (flagellin): molecular cloning, expression, and amplification of the
RT gene.";
RL Infect. Immun. 58:1711-1719(1990).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=CA12;
RX PubMed=1702766; DOI=10.1128/iai.59.2.514-520.1991;
RA Collins C., Peltz G.;
RT "Immunoreactive epitopes on an expressed recombinant flagellar protein of
RT Borrelia burgdorferi.";
RL Infect. Immun. 59:514-520(1991).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KA;
RX PubMed=8234271; DOI=10.1073/pnas.90.21.10163;
RA Dykhuizen D.E., Polin D.S., Dunn J.J., Wilske B., Preac-Mursic V.,
RA Dattwyler R.J., Luft B.J.;
RT "Borrelia burgdorferi is clonal: implications for taxonomy and vaccine
RT development.";
RL Proc. Natl. Acad. Sci. U.S.A. 90:10163-10167(1993).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX PubMed=9403685; DOI=10.1038/37551;
RA Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L.,
RA Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L.,
RA Peterson J.D., Kerlavage A.R., Quackenbush J., Salzberg S.L., Hanson M.,
RA van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F.,
RA Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C.,
RA Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B.,
RA Smith H.O., Venter J.C.;
RT "Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.";
RL Nature 390:580-586(1997).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-64.
RC STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX PubMed=1734073; DOI=10.1128/jcm.30.1.99-114.1992;
RA Picken R.N.;
RT "Polymerase chain reaction primers and probes derived from flagellin gene
RT sequences for specific detection of the agents of Lyme disease and North
RT American relapsing fever.";
RL J. Clin. Microbiol. 30:99-114(1992).
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 174-237.
RC STRAIN=212, ATCC 35210 / DSM 4680 / CIP 102532 / B31, CA55, and DN127;
RA Assous M.V., Postic D.D.P., Paul G.G.P., Nevot P.P.N., Baranton G.G.B.;
RL Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 157-324.
RC STRAIN=212, DK-5, and GeHo;
RA Curtin S.M., Maggs A.D.F., Carter P.E., Pennington T.H.;
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN [10]
RP PROTEIN SEQUENCE OF 1-18.
RC STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX PubMed=2807540; DOI=10.1128/iai.57.11.3637-3645.1989;
RA Luft B.J., Jiang W., Munoz P., Dattwyler R.J., Gorevic P.D.;
RT "Biochemical and immunological characterization of the surface proteins of
RT Borrelia burgdorferi.";
RL Infect. Immun. 57:3637-3645(1989).
RN [11]
RP PROTEIN SEQUENCE OF 1-10.
RC STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX PubMed=2738156; DOI=10.1172/jci114157;
RA Coleman J.L., Benach J.L.;
RT "Identification and characterization of an endoflagellar antigen of
RT Borrelia burgdorferi.";
RL J. Clin. Invest. 84:322-330(1989).
CC -!- FUNCTION: Component of the core of the flagella.
CC -!- SUBUNIT: The flagellum consists of an outer layer composed of repeating
CC units of FlaA around a core that contains several antigenically related
CC polypeptides.
CC -!- SUBCELLULAR LOCATION: Periplasmic flagellum. Periplasm.
CC -!- SIMILARITY: Belongs to the bacterial flagellin family. {ECO:0000305}.
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DR EMBL; X15660; CAA33695.1; -; Genomic_DNA.
DR EMBL; X15661; CAA33696.1; -; Genomic_DNA.
DR EMBL; X16833; CAA34735.1; -; Genomic_DNA.
DR EMBL; X56334; CAA39770.1; -; Genomic_DNA.
DR EMBL; M34710; AAA65584.1; -; Genomic_DNA.
DR EMBL; L29244; AAA22942.1; -; Genomic_DNA.
DR EMBL; L29200; AAB38539.1; -; Genomic_DNA.
DR EMBL; L29234; AAA22944.1; -; Genomic_DNA.
DR EMBL; L29243; AAA22941.1; -; Genomic_DNA.
DR EMBL; X69611; CAA49319.1; -; Genomic_DNA.
DR EMBL; AE000783; AAC66541.1; -; Genomic_DNA.
DR EMBL; Y15090; CAA75365.1; -; Genomic_DNA.
DR EMBL; Y15092; CAA75367.1; -; Genomic_DNA.
DR EMBL; Y15093; CAA75368.1; -; Genomic_DNA.
DR PIR; A38450; A38450.
DR PIR; A41470; FLLYB3.
DR PIR; I40092; I40092.
DR RefSeq; NP_212281.1; NC_001318.1.
DR RefSeq; WP_002661938.1; NC_001318.1.
DR AlphaFoldDB; P11089; -.
DR SMR; P11089; -.
DR STRING; 224326.BB_0147; -.
DR PRIDE; P11089; -.
DR EnsemblBacteria; AAC66541; AAC66541; BB_0147.
DR GeneID; 56568071; -.
DR KEGG; bbu:BB_0147; -.
DR PATRIC; fig|224326.49.peg.546; -.
DR HOGENOM; CLU_011142_2_0_12; -.
DR OMA; FEHTINN; -.
DR Proteomes; UP000001807; Chromosome.
DR GO; GO:0016020; C:membrane; IDA:CAFA.
DR GO; GO:0055040; C:periplasmic flagellum; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR InterPro; IPR001444; Flag_bb_rod_N.
DR InterPro; IPR019776; Flagellar_basal_body_rod_CS.
DR InterPro; IPR001492; Flagellin.
DR InterPro; IPR046358; Flagellin_C.
DR InterPro; IPR001029; Flagellin_N.
DR PANTHER; PTHR42792; PTHR42792; 1.
DR Pfam; PF00700; Flagellin_C; 1.
DR Pfam; PF00669; Flagellin_N; 1.
DR Pfam; PF00460; Flg_bb_rod; 1.
DR PRINTS; PR00207; FLAGELLIN.
DR PROSITE; PS00588; FLAGELLA_BB_ROD; 1.
PE 1: Evidence at protein level;
KW Bacterial flagellum; Direct protein sequencing; Periplasm;
KW Reference proteome.
FT CHAIN 1..336
FT /note="Flagellar filament 41 kDa core protein"
FT /id="PRO_0000182590"
FT REGION 208..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 156
FT /note="A -> S (in strain: 212)"
FT VARIANT 279
FT /note="D -> N (in strain: B31 and KA)"
FT CONFLICT 180
FT /note="N -> T (in Ref. 3; CAA33696/CAA34735)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 336 AA; 35766 MW; 3EE4A15CC1D361E9 CRC64;
MIINHNTSAI NASRNNGINA ANLSKTQEKL SSGYRINRAS DDAAGMGVSG KINAQIRGLS
QASRNTSKAI NFIQTTEGNL NEVEKVLVRM KELAVQSGNG TYSDADRGSI QIEIEQLTDE
INRIADQAQY NQMHMLSNKS ASQNVRTAEE LGMQPAKINT PASLSGSQAS WTLRVHVGAN
QDEAIAVNIY AANVANLFSG EGAQTAQAAP VQEGVQQEGA QQPAPATAPS QGGVNSPVNV
TTTVDANTSL AKIENAIRMI SDQRANLGAF QNRLESIKDS TEYAIENLKA SYAQIKDATM
TDEVVAATTN SILTQSAMAM IAQANQVPQY VLSLLR
