ID   FLA1_CAMJE              Reviewed;         572 AA.
AC   P56963; Q0P8S0; Q9PMW0;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Flagellin A;
GN   Name=flaA; OrderedLocusNames=Cj1339c;
OS   Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC
OS   11168).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=192222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700819 / NCTC 11168;
RX   PubMed=10688204; DOI=10.1038/35001088;
RA   Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M.,
RA   Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S.,
RA   Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A.,
RA   Rajandream M.A., Rutherford K.M., van Vliet A.H.M., Whitehead S.,
RA   Barrell B.G.;
RT   "The genome sequence of the food-borne pathogen Campylobacter jejuni
RT   reveals hypervariable sequences.";
RL   Nature 403:665-668(2000).
RN   [2]
RP   INTERACTION WITH FLIW, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 700819 / NCTC 11168;
RX   PubMed=27229370; DOI=10.1038/ncomms11667;
RA   Dugar G., Svensson S.L., Bischler T., Waeldchen S., Reinhardt R., Sauer M.,
RA   Sharma C.M.;
RT   "The CsrA-FliW network controls polar localization of the dual-function
RT   flagellin mRNA in Campylobacter jejuni.";
RL   Nat. Commun. 7:11667-11667(2016).
CC   -!- FUNCTION: Flagellin is the subunit protein which polymerizes to form
CC       the filaments of bacterial flagella. FlaA binds to flagellar assembly
CC       factor FliW protein, preventing FliW from binding to CsrA, so that CsrA
CC       can then bind flaA mRNA and represses its translation.
CC       {ECO:0000269|PubMed:27229370}.
CC   -!- SUBUNIT: Heteromer of FlaA and FlaB. Interacts with FliW.
CC       {ECO:0000269|PubMed:27229370}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Bacterial flagellum.
CC   -!- DISRUPTION PHENOTYPE: Has 2 short flagella probably composed of
CC       flagellin B (flaB). {ECO:0000269|PubMed:27229370}.
CC   -!- MISCELLANEOUS: The mRNA is localized to the poles of short, probably
CC       elongating, cells; mRNA localization is lost in an fliW deletion strain
CC       but restored in a csrA-fliW double deletion. Correct localization
CC       requires protein translation; mutation of the start codon to prevent
CC       translation initiation or a premature stop codon (at position 3)
CC       prevents mRNA localization, a stop codon at position 101 leads to
CC       partial localization to the cell poles. {ECO:0000269|PubMed:27229370}.
CC   -!- SIMILARITY: Belongs to the bacterial flagellin family. {ECO:0000305}.
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DR   EMBL; AL111168; CAL35451.1; -; Genomic_DNA.
DR   PIR; H81277; H81277.
DR   RefSeq; WP_010891927.1; NC_002163.1.
DR   RefSeq; YP_002344727.1; NC_002163.1.
DR   AlphaFoldDB; P56963; -.
DR   SMR; P56963; -.
DR   IntAct; P56963; 5.
DR   STRING; 192222.Cj1339c; -.
DR   PaxDb; P56963; -.
DR   PRIDE; P56963; -.
DR   EnsemblBacteria; CAL35451; CAL35451; Cj1339c.
DR   GeneID; 905631; -.
DR   KEGG; cje:Cj1339c; -.
DR   PATRIC; fig|192222.6.peg.1321; -.
DR   eggNOG; COG1344; Bacteria.
DR   HOGENOM; CLU_011142_7_1_7; -.
DR   OMA; MAERNAM; -.
DR   Proteomes; UP000000799; Chromosome.
DR   GO; GO:0009288; C:bacterial-type flagellum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 6.10.10.10; -; 1.
DR   InterPro; IPR001492; Flagellin.
DR   InterPro; IPR046358; Flagellin_C.
DR   InterPro; IPR042187; Flagellin_C_sub2.
DR   InterPro; IPR010810; Flagellin_hook_IN_motif.
DR   InterPro; IPR001029; Flagellin_N.
DR   PANTHER; PTHR42792; PTHR42792; 1.
DR   Pfam; PF00700; Flagellin_C; 1.
DR   Pfam; PF07196; Flagellin_IN; 2.
DR   Pfam; PF00669; Flagellin_N; 1.
DR   PRINTS; PR00207; FLAGELLIN.
PE   1: Evidence at protein level;
KW   Bacterial flagellum; Reference proteome; Secreted.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..572
FT                   /note="Flagellin A"
FT                   /id="PRO_0000182593"
SQ   SEQUENCE   572 AA;  59039 MW;  BC0742BD852259EA CRC64;
     MGFRINTNVA ALNAKANADL NSKSLDASLS RLSSGLRINS AADDASGMAI ADSLRSQANT
     LGQAISNGND ALGILQTADK AMDEQLKILD TIKTKATQAA QDGQSLKTRT MLQADINRLM
     EELDNIANTT SFNGKQLLSG NFINQEFQIG ASSNQTVKAT IGATQSSKIG LTRFETGGRI
     STSGEVQFTL KNYNGIDDFQ FQKVVISTSV GTGLGALADE INKNADKTGV RATFTVETRG
     IAAVRAGATS DTFAINGVKI GKVDYKDGDA NGALVAAINS VKDTTGVEAS IDANGQLLLT
     SREGRGIKID GNIGGGAFIN ADMKENYGRL SLVKNDGKDI LISGSNLSSA GFGATQFISQ
     ASVSLRESKG QIDANIADAM GFGSANKGVV LGGYSSVSAY MSSAGSGFSS GSGYSVGSGK
     NYSTGFANAI AISAASQLST VYNVSAGSGF SSGSTLSQFA TMKTTAFGVK DETAGVTTLK
     GAMAVMDIAE TAITNLDQIR ADIGSVQNQV TSTINNITVT QVNVKAAESQ IRDVDFAAES
     ANYSKANILA QSGSYAMAQA NSVQQNVLRL LQ