FLA8_ARATH
ID FLA8_ARATH Reviewed; 420 AA.
AC O22126; Q56ZW9; Q8L9B1; Q9FR46;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 143.
DE RecName: Full=Fasciclin-like arabinogalactan protein 8;
DE Short=AtAGP8;
DE Flags: Precursor;
GN Name=FLA8; OrderedLocusNames=At2g45470; ORFNames=F4L23.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 98-420, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=11006345; DOI=10.2307/3871187;
RA Schultz C.J., Johnson K.L., Currie G., Bacic A.;
RT "The classical arabinogalactan protein gene family of Arabidopsis.";
RL Plant Cell 12:1751-1767(2000).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 98-420.
RC STRAIN=cv. Columbia;
RX PubMed=11554470; DOI=10.1023/a:1010683432529;
RA Gaspar Y., Johnson K.L., McKenna J.A., Bacic A., Schultz C.J.;
RT "The complex structures of arabinogalactan-proteins and the journey towards
RT understanding function.";
RL Plant Mol. Biol. 47:161-176(2001).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 344-420.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP GENE FAMILY ORGANIZATION, NOMENCLATURE, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=14645732; DOI=10.1104/pp.103.031237;
RA Johnson K.L., Jones B.J., Bacic A., Schultz C.J.;
RT "The fasciclin-like arabinogalactan proteins of Arabidopsis. A multigene
RT family of putative cell adhesion molecules.";
RL Plant Physiol. 133:1911-1925(2003).
CC -!- FUNCTION: May be a cell surface adhesion protein.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
CC -!- TISSUE SPECIFICITY: Expressed mainly in flowers and to a lesser extent
CC in leaves and roots. {ECO:0000269|PubMed:11006345,
CC ECO:0000269|PubMed:14645732}.
CC -!- INDUCTION: Down-regulated by abscisic acid (ABA).
CC {ECO:0000269|PubMed:14645732}.
CC -!- SIMILARITY: Belongs to the fasciclin-like AGP family. {ECO:0000305}.
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DR EMBL; AC002387; AAB82617.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10559.1; -; Genomic_DNA.
DR EMBL; AY094443; AAM19815.1; -; mRNA.
DR EMBL; AY149956; AAN31110.1; -; mRNA.
DR EMBL; AY088542; AAM66074.1; -; mRNA.
DR EMBL; AF195889; AAG24276.1; -; mRNA.
DR EMBL; AK220841; BAD94169.1; -; mRNA.
DR PIR; H84890; H84890.
DR RefSeq; NP_566043.1; NM_130109.3.
DR AlphaFoldDB; O22126; -.
DR SMR; O22126; -.
DR BioGRID; 4491; 1.
DR STRING; 3702.AT2G45470.1; -.
DR PaxDb; O22126; -.
DR PRIDE; O22126; -.
DR ProteomicsDB; 228912; -.
DR EnsemblPlants; AT2G45470.1; AT2G45470.1; AT2G45470.
DR GeneID; 819155; -.
DR Gramene; AT2G45470.1; AT2G45470.1; AT2G45470.
DR KEGG; ath:AT2G45470; -.
DR Araport; AT2G45470; -.
DR TAIR; locus:2050822; AT2G45470.
DR eggNOG; ENOG502QV96; Eukaryota.
DR HOGENOM; CLU_036139_0_0_1; -.
DR InParanoid; O22126; -.
DR OMA; TRETITC; -.
DR OrthoDB; 984651at2759; -.
DR PhylomeDB; O22126; -.
DR PRO; PR:O22126; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O22126; baseline and differential.
DR Genevisible; O22126; AT.
DR GO; GO:0031225; C:anchored component of membrane; TAS:TAIR.
DR GO; GO:0046658; C:anchored component of plasma membrane; IDA:TAIR.
DR GO; GO:0048046; C:apoplast; HDA:TAIR.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0099503; C:secretory vesicle; HDA:TAIR.
DR Gene3D; 2.30.180.10; -; 2.
DR InterPro; IPR036378; FAS1_dom_sf.
DR InterPro; IPR000782; FAS1_domain.
DR InterPro; IPR033254; Plant_FLA.
DR PANTHER; PTHR32382; PTHR32382; 1.
DR Pfam; PF02469; Fasciclin; 1.
DR SMART; SM00554; FAS1; 1.
DR SUPFAM; SSF82153; SSF82153; 2.
DR PROSITE; PS50213; FAS1; 2.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Proteoglycan; Reference proteome; Repeat; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..392
FT /note="Fasciclin-like arabinogalactan protein 8"
FT /id="PRO_0000008780"
FT PROPEP 393..420
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000008781"
FT DOMAIN 26..172
FT /note="FAS1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00082"
FT DOMAIN 186..326
FT /note="FAS1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00082"
FT REGION 335..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..375
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 392
FT /note="GPI-anchor amidated asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 128
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 162
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 189
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 273
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 412
FT /note="I -> V (in Ref. 4, 5 and 6)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 420 AA; 43075 MW; 0387BEE37881004B CRC64;
MAASQTFSLL AFTFSLLAFA STVSSHNITQ ILADSPDYSS FNSYLSQTKL ADEINSRTTI
TVLVLNNGAM SALAGKHPLS VIKSALSLLV LLDYYDPQKL HKISKGTTLS TTLYQTTGNA
PGNLGFVNIT DLKGGKVGFG SAASGSKLDS SYTKSVKQIP YNISILEIDA PIIAPGVLTA
PAPSASLSNI TGLLEKAGCK TFANLLVSSG VLKTYESAVE KGLTVFAPSD EAFKAEGVPD
LTKLTQAEVV SLLEYHALAE YKPKGSLKTN KNNISTLATN GAGKFDLTTS TSGDEVILHT
GVAPSRLADT VLDATPVVIF TVDNVLLPAE LFGKSKSPSP APAPEPVTAP TPSPADAPSP
TAASPPAPPT DESPESAPSD SPTGSANSKS ANAAVGVSTP SLFTALVTIA AIAVSVSLCS
