FLAAL_BRAHW
ID FLAAL_BRAHW Reviewed; 216 AA.
AC C0QWY9; C4MGG5;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 1.
DT 25-MAY-2022, entry version 52.
DE RecName: Full=Putative flagellar filament outer layer-like protein;
DE AltName: Full=P-H42;
GN Name=flaAL; OrderedLocusNames=BHWA1_02338;
OS Brachyspira hyodysenteriae (strain ATCC 49526 / WA1).
OC Bacteria; Spirochaetes; Brachyspirales; Brachyspiraceae; Brachyspira.
OX NCBI_TaxID=565034;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND BIOTECHNOLOGY.
RX PubMed=19179021; DOI=10.1016/j.vetmic.2008.12.018;
RA Song Y., La T., Phillips N.D., Bellgard M.I., Hampson D.J.;
RT "A reverse vaccinology approach to swine dysentery vaccine development.";
RL Vet. Microbiol. 137:111-119(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49526 / WA1;
RX PubMed=19262690; DOI=10.1371/journal.pone.0004641;
RA Bellgard M.I., Wanchanthuek P., La T., Ryan K., Moolhuijzen P.,
RA Albertyn Z., Shaban B., Motro Y., Dunn D.S., Schibeci D., Hunter A.,
RA Barrero R., Phillips N.D., Hampson D.J.;
RT "Genome sequence of the pathogenic intestinal spirochete Brachyspira
RT hyodysenteriae reveals adaptations to its lifestyle in the porcine large
RT intestine.";
RL PLoS ONE 4:E4641-E4641(2009).
CC -!- FUNCTION: Might be part of the flagella. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Periplasmic flagellum. Periplasm {ECO:0000305}.
CC -!- BIOTECHNOLOGY: Has shown promise in a 4-component vaccine with
CC BHWA1_00430 (AC C0QY54), SecA (AC C0QZS7) and BHWA1_00569 (AC C0QYX7).
CC {ECO:0000269|PubMed:19179021}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ACD74839.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; EU555169; ACD74839.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP001357; ACN84792.1; -; Genomic_DNA.
DR AlphaFoldDB; C0QWY9; -.
DR STRING; 565034.BHWA1_02338; -.
DR EnsemblBacteria; ACN84792; ACN84792; BHWA1_02338.
DR KEGG; bhy:BHWA1_02338; -.
DR eggNOG; ENOG5033RD4; Bacteria.
DR HOGENOM; CLU_097187_0_0_12; -.
DR OMA; FEFANTW; -.
DR Proteomes; UP000001803; Chromosome.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR GO; GO:0055040; C:periplasmic flagellum; IEA:UniProtKB-SubCell.
DR GO; GO:0071973; P:bacterial-type flagellum-dependent cell motility; IEA:InterPro.
DR InterPro; IPR006714; FlaA.
DR Pfam; PF04620; FlaA; 1.
PE 1: Evidence at protein level;
KW Bacterial flagellum; Periplasm.
FT CHAIN 1..216
FT /note="Putative flagellar filament outer layer-like
FT protein"
FT /id="PRO_0000380706"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 216 AA; 24763 MW; 41F87E739BF1D824 CRC64;
MFAQDAAQTG EQTTQNQGEN GNNFVTEAIT NYLIDDFEFA NTWQASMPRD YGVVSIIRRE
GGPADVVAEG AENNKYILGA KVEYFRTGYP WFSVTPPRPV KIPGYTKELS VWVAGRNHNN
RMSFYVYDVN GKPQAVGNEA LNFMGWKNIT VQIPANIRQE EFRGQVEQGI SFMGIHVKVD
PRDSYGKYYI YFDQLMAKTD MYLETYREED DPLDTW