ID   FLAA_HELMU              Reviewed;         494 AA.
AC   P50612;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Flagellin A;
GN   Name=flaA;
OS   Helicobacter mustelae.
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=217;
RN   [1]
RP   PROTEIN SEQUENCE OF 1-15.
RC   STRAIN=NCTC 12032;
RX   PubMed=1548093; DOI=10.1128/iai.60.4.1695-1698.1992;
RA   Suerbaum S., Geis G., Josenhans C., Opferkuch W.;
RT   "Biochemical studies of Helicobacter mustelae fatty acid composition and
RT   flagella.";
RL   Infect. Immun. 60:1695-1698(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 13-494.
RC   STRAIN=NCTC 12032;
RX   PubMed=7768796; DOI=10.1128/jb.177.11.3010-3020.1995;
RA   Josenhans C., Labigne A., Suerbaum S.;
RT   "Comparative ultrastructural and functional studies of Helicobacter pylori
RT   and Helicobacter mustelae flagellin mutants: both flagellin subunits, FlaA
RT   and FlaB, are necessary for full motility in Helicobacter species.";
RL   J. Bacteriol. 177:3010-3020(1995).
CC   -!- FUNCTION: Flagellin is the subunit protein which polymerizes to form
CC       the filaments of bacterial flagella. Important for motility and
CC       virulence.
CC   -!- SUBUNIT: Heteromer of FlaA and FlaB. FlaB is located proximal to the
CC       hook while the remainder of the filament is composed of the predominant
CC       FlaA.
CC   -!- SUBCELLULAR LOCATION: Secreted. Bacterial flagellum.
CC   -!- SIMILARITY: Belongs to the bacterial flagellin family. {ECO:0000305}.
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DR   EMBL; L38478; AAC41457.1; -; Genomic_DNA.
DR   PIR; A57269; A57269.
DR   AlphaFoldDB; P50612; -.
DR   SMR; P50612; -.
DR   PRIDE; P50612; -.
DR   GO; GO:0009288; C:bacterial-type flagellum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 6.10.10.10; -; 1.
DR   InterPro; IPR001492; Flagellin.
DR   InterPro; IPR046358; Flagellin_C.
DR   InterPro; IPR042187; Flagellin_C_sub2.
DR   InterPro; IPR010810; Flagellin_hook_IN_motif.
DR   InterPro; IPR001029; Flagellin_N.
DR   PANTHER; PTHR42792; PTHR42792; 1.
DR   Pfam; PF00700; Flagellin_C; 1.
DR   Pfam; PF07196; Flagellin_IN; 2.
DR   Pfam; PF00669; Flagellin_N; 1.
DR   PRINTS; PR00207; FLAGELLIN.
PE   1: Evidence at protein level;
KW   Bacterial flagellum; Direct protein sequencing; Secreted; Virulence.
FT   CHAIN           1..494
FT                   /note="Flagellin A"
FT                   /id="PRO_0000182608"
SQ   SEQUENCE   494 AA;  51327 MW;  4B721C4B07246BAC CRC64;
     AFQVNTNINA LTTSAGATQL GLKNSLEKLS SGLRINKAAD DASGMTISDS LRSQASALGQ
     AISNANDGIG IIQVADKAMD EQLKILDTIK VKATQAAQDG QSLESRKAIQ SDIIRLIQGL
     DNIGNTTSYN GQSLLSGQWT NKEFQIGTYS NQSIKVSVGS TTSDKIGQVR INTGAMITAA
     SEATLTFKQI NGGGTSPLEG VKISHSVGTG LGVLAEVINK NSDKTGIRAK ASVETTSDKE
     IMSGNLKNLT INDVNIGNIV DIKKGDADGR LVQAINALTS STGVEASTDS KGRLNLRSVD
     GRGIVLKADA SEDNGDGKSA PMAIDAVNGG QSITDGEGAA NYGRLSLVRL DARDIVLTSS
     DKPDENKFSA IGFGDNNVAM ATVNLRDVLG KFDASVKSAS GANYNAVIAS GNSNLGAGVT
     TLVGAMLVMD IADSARKTLD KIRSDLGSVQ GQMVSTVNNI SVTQVNVKAA ESRMREVDFA
     AESAEFNKYN ILAQ