ID   FLAA_HELPY              Reviewed;         510 AA.
AC   P0A0S1; Q03843;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Flagellin A;
GN   Name=flaA; OrderedLocusNames=HP_0601;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-14.
RC   STRAIN=NTCC 11637 / Isolate 898-1;
RX   PubMed=1435261; DOI=10.1111/j.1365-2958.1992.tb01466.x;
RA   Leying H., Suerbaum S., Geis G., Haas R.;
RT   "Cloning and genetic characterization of a Helicobacter pylori flagellin
RT   gene.";
RL   Mol. Microbiol. 6:2863-2874(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
RN   [3]
RP   PROTEIN SEQUENCE OF 2-27, AND CHARACTERIZATION.
RC   STRAIN=NTCC 11637 / Isolate 5294, and NTCC 11637 / Isolate 915;
RX   PubMed=1704004; DOI=10.1128/jb.173.3.937-946.1991;
RA   Kostrzynska M., Betts J.D., Austin J.W., Trust T.J.;
RT   "Identification, characterization, and spatial localization of two
RT   flagellin species in Helicobacter pylori flagella.";
RL   J. Bacteriol. 173:937-946(1991).
CC   -!- FUNCTION: Flagellin is the subunit protein which polymerizes to form
CC       the filaments of bacterial flagella. Important for motility and
CC       virulence.
CC   -!- SUBUNIT: Heteromer of FlaA and FlaB. FlaB is located proximal to the
CC       hook while the remainder of the filament is composed of the predominant
CC       FlaA.
CC   -!- SUBCELLULAR LOCATION: Secreted. Bacterial flagellum.
CC   -!- SIMILARITY: Belongs to the bacterial flagellin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X60746; CAA43148.1; -; Genomic_DNA.
DR   EMBL; AE000511; AAD07667.1; -; Genomic_DNA.
DR   PIR; A64595; A64595.
DR   RefSeq; NP_207396.1; NC_000915.1.
DR   RefSeq; WP_000885496.1; NC_018939.1.
DR   AlphaFoldDB; P0A0S1; -.
DR   SMR; P0A0S1; -.
DR   IntAct; P0A0S1; 6.
DR   MINT; P0A0S1; -.
DR   STRING; 85962.C694_03110; -.
DR   PaxDb; P0A0S1; -.
DR   EnsemblBacteria; AAD07667; AAD07667; HP_0601.
DR   GeneID; 66521826; -.
DR   KEGG; hpy:HP_0601; -.
DR   PATRIC; fig|85962.47.peg.649; -.
DR   eggNOG; COG1344; Bacteria.
DR   OMA; MAERNAM; -.
DR   PhylomeDB; P0A0S1; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0009288; C:bacterial-type flagellum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0071978; P:bacterial-type flagellum-dependent swarming motility; IMP:CACAO.
DR   Gene3D; 6.10.10.10; -; 1.
DR   InterPro; IPR001492; Flagellin.
DR   InterPro; IPR046358; Flagellin_C.
DR   InterPro; IPR042187; Flagellin_C_sub2.
DR   InterPro; IPR010810; Flagellin_hook_IN_motif.
DR   InterPro; IPR001029; Flagellin_N.
DR   PANTHER; PTHR42792; PTHR42792; 1.
DR   Pfam; PF00700; Flagellin_C; 1.
DR   Pfam; PF07196; Flagellin_IN; 2.
DR   Pfam; PF00669; Flagellin_N; 1.
DR   PRINTS; PR00207; FLAGELLIN.
PE   1: Evidence at protein level;
KW   Bacterial flagellum; Direct protein sequencing; Reference proteome;
KW   Secreted; Virulence.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:1435261,
FT                   ECO:0000269|PubMed:1704004"
FT   CHAIN           2..510
FT                   /note="Flagellin A"
FT                   /id="PRO_0000182609"
FT   VARIANT         15
FT                   /note="H -> G (in strain: Isolate 5294)"
FT   CONFLICT        19
FT                   /note="A -> E (in Ref. 1; CAA43148)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   510 AA;  53284 MW;  E802CCB74474A65A CRC64;
     MAFQVNTNIN AMNAHVQSAL TQNALKTSLE RLSSGLRINK AADDASGMTV ADSLRSQASS
     LGQAIANTND GMGIIQVADK AMDEQLKILD TVKVKATQAA QDGQTTESRK AIQSDIVRLI
     QGLDNIGNTT TYNGQALLSG QFTNKEFQVG AYSNQSIKAS IGSTTSDKIG QVRIATGALI
     TASGDISLTF KQVDGVNDVT LESVKVSSSA GTGIGVLAEV INKNSNRTGV KAYASVITTS
     DVAVQSGSLS NLTLNGIHLG NIADIKKNDS DGRLVAAINA VTSETGVEAY TDQKGRLNLR
     SIDGRGIEIK TDSVSNGPSA LTMVNGGQDL TKGSTNYGRL SLTRLDAKSI NVVSASDSQH
     LGFTAIGFGE SQVAETTVNL RDVTGNFNAN VKSASGANYN AVIASGNQSL GSGVTTLRGA
     MVVIDIAESA MKMLDKVRSD LGSVQNQMIS TVNNISITQV NVKAAESQIR DVDFAEESAN
     FNKNNILAQS GSYAMSQANT VQQNILRLLT