ID   FLAA_TREPA              Reviewed;         350 AA.
AC   P18193;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 2.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Flagellar filament outer layer protein;
DE   AltName: Full=Sheath protein;
DE   Flags: Precursor;
GN   Name=flaA; OrderedLocusNames=TP_0249;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2194955; DOI=10.1128/iai.58.7.2025-2034.1990;
RA   Isaacs R.D., Radolf J.D.;
RT   "Expression in Escherichia coli of the 37-kilodalton endoflagellar sheath
RT   protein of Treponema pallidum by use of the polymerase chain reaction and a
RT   T7 expression system.";
RL   Infect. Immun. 58:2025-2034(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-350.
RC   STRAIN=Nichols;
RX   PubMed=2680972; DOI=10.1128/iai.57.11.3403-3411.1989;
RA   Isaacs R.D., Hanke J.H., Guzman-Verduzco L.-M., Newport G., Agabian N.,
RA   Norgard M.V., Lukehart S.A., Radolf J.D.;
RT   "Molecular cloning and DNA sequence analysis of the 37-kilodalton
RT   endoflagellar sheath protein gene of Treponema pallidum.";
RL   Infect. Immun. 57:3403-3411(1989).
RN   [4]
RP   SUBCELLULAR LOCATION.
RX   PubMed=16159783; DOI=10.1128/jb.187.18.6499-6508.2005;
RA   Hazlett K.R., Cox D.L., Decaffmeyer M., Bennett M.P., Desrosiers D.C.,
RA   La Vake C.J., La Vake M.E., Bourell K.W., Robinson E.J., Brasseur R.,
RA   Radolf J.D.;
RT   "TP0453, a concealed outer membrane protein of Treponema pallidum, enhances
RT   membrane permeability.";
RL   J. Bacteriol. 187:6499-6508(2005).
RN   [5]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=Nichols-Farmington;
RX   PubMed=25825429; DOI=10.1128/jb.00086-15;
RA   Luthra A., Anand A., Hawley K.L., LeDoyt M., La Vake C.J., Caimano M.J.,
RA   Cruz A.R., Salazar J.C., Radolf J.D.;
RT   "A homology model reveals novel structural features and an immunodominant
RT   surface loop/opsonic target in the Treponema pallidum BamA ortholog
RT   TP_0326.";
RL   J. Bacteriol. 197:1906-1920(2015).
CC   -!- FUNCTION: Component of the outer layer of the flagella.
CC   -!- SUBUNIT: The flagellum consists of an outer layer composed of repeating
CC       units of FlaA around a core that contains several antigenically related
CC       polypeptides.
CC   -!- SUBCELLULAR LOCATION: Periplasmic flagellum. Periplasm
CC       {ECO:0000269|PubMed:25825429, ECO:0000305|PubMed:16159783}.
CC       Note=Antibody labeling only occurs after mild detergent solubilization
CC       (PubMed:25825429). {ECO:0000269|PubMed:25825429}.
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DR   EMBL; M63142; AAA27477.1; -; Genomic_DNA.
DR   EMBL; AE000520; AAC65235.1; -; Genomic_DNA.
DR   EMBL; M26525; AAA27476.1; -; Genomic_DNA.
DR   PIR; D71348; D71348.
DR   RefSeq; WP_010881697.1; NC_021490.2.
DR   AlphaFoldDB; P18193; -.
DR   IntAct; P18193; 1.
DR   STRING; 243276.TPANIC_0249; -.
DR   EnsemblBacteria; AAC65235; AAC65235; TP_0249.
DR   GeneID; 57878791; -.
DR   KEGG; tpa:TP_0249; -.
DR   eggNOG; ENOG50329D7; Bacteria.
DR   HOGENOM; CLU_821088_0_0_12; -.
DR   OMA; EDMSGME; -.
DR   OrthoDB; 735776at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR   GO; GO:0055040; C:periplasmic flagellum; IEA:UniProtKB-SubCell.
DR   GO; GO:0071973; P:bacterial-type flagellum-dependent cell motility; IEA:InterPro.
DR   InterPro; IPR006714; FlaA.
DR   InterPro; IPR016369; FlaA_Spirochaetes.
DR   Pfam; PF04620; FlaA; 1.
DR   PIRSF; PIRSF002892; Flagellin_A; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum; Periplasm; Reference proteome; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..350
FT                   /note="Flagellar filament outer layer protein"
FT                   /id="PRO_0000009354"
SQ   SEQUENCE   350 AA;  38857 MW;  2BC7C7EFA0CDB4C7 CRC64;
     MKKAVVLSAV ALLSGVCAVA DESVLIDFAK LNADIMADKS GGMTHNRRTV LDYASLADTS
     YTDEQKALMR SSLAVAQWEV VLNSSARNPV AHAASRVIEA PVSEGAKSFA GERVLGVRVL
     FPTWDSNANA MIKPAFVIPA YEVMAQVDDQ GNVQAPTEEE KASGKGRFED GYGVVKNVGV
     LKSIAVNTYG MNYPHGLYVM MRDQDGEVHR YFMGYLLFDS WKELVWNNPS YISDVRSREV
     RLYPVYPAST PHVVFEGFMV TRDAAHAGGD YVGYFKDVKI IYDKAVLSTV RDFADEDLWG
     IQARREAERK RVEVARFGQQ QVLRYIEQEK LATEVGFTPS GGAQRQEEQQ