ID   FLAA_VIBAN              Reviewed;         379 AA.
AC   Q60246;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Flagellin A;
GN   Name=flaA;
OS   Vibrio anguillarum (Listonella anguillarum).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=55601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NB10 / Serotype O1;
RX   PubMed=8631707; DOI=10.1128/jb.178.5.1310-1319.1996;
RA   Milton D.L., O'Toole R., Hoerstedt P., Wolf-Watz H.;
RT   "Flagellin A is essential for the virulence of Vibrio anguillarum.";
RL   J. Bacteriol. 178:1310-1319(1996).
CC   -!- FUNCTION: Flagellin is the subunit protein which polymerizes to form
CC       the filaments of bacterial flagella. FlaA is essential for flagellar
CC       synthesis and full motility. Important for virulence at two different
CC       levels: is needed for crossing the fish integument and may play a role
CC       once the bacterium has entered the host.
CC   -!- SUBUNIT: Heteromer of multiple flagellin subunits including FlaA, FlaB,
CC       FlaC, FlaD and possibly FlaE.
CC   -!- SUBCELLULAR LOCATION: Secreted. Bacterial flagellum.
CC   -!- SIMILARITY: Belongs to the bacterial flagellin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L47122; AAB05995.1; -; Genomic_DNA.
DR   PIR; JC6021; JC6021.
DR   RefSeq; WP_017045944.1; NZ_VSLF01000002.1.
DR   AlphaFoldDB; Q60246; -.
DR   SMR; Q60246; -.
DR   STRING; 55601.VANGNB10_cI1986c; -.
DR   PRIDE; Q60246; -.
DR   GeneID; 63946350; -.
DR   OrthoDB; 636786at2; -.
DR   GO; GO:0009288; C:bacterial-type flagellum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 6.10.10.10; -; 1.
DR   InterPro; IPR001492; Flagellin.
DR   InterPro; IPR046358; Flagellin_C.
DR   InterPro; IPR042187; Flagellin_C_sub2.
DR   InterPro; IPR010810; Flagellin_hook_IN_motif.
DR   InterPro; IPR001029; Flagellin_N.
DR   PANTHER; PTHR42792; PTHR42792; 1.
DR   Pfam; PF00700; Flagellin_C; 1.
DR   Pfam; PF07196; Flagellin_IN; 1.
DR   Pfam; PF00669; Flagellin_N; 1.
DR   PRINTS; PR00207; FLAGELLIN.
PE   3: Inferred from homology;
KW   Bacterial flagellum; Coiled coil; Secreted; Virulence.
FT   CHAIN           1..379
FT                   /note="Flagellin A"
FT                   /id="PRO_0000182643"
FT   COILED          103..128
FT                   /evidence="ECO:0000255"
FT   COILED          302..341
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   379 AA;  40112 MW;  5D79394BA90B7976 CRC64;
     MTITVNTNVS AMTAQRYLNK ATGELNTSME RLSSGNKINS AKDDAAGLQI SNRLTAQSRG
     LDVAMRNAND GISIAQTAEG AMNESTSILQ RMRDLALQSA NGTNSASERQ ALDEESTALQ
     DELNRIAETT SFGGRKLLNG SFGEASFQIG ASSGEAIIMG LTSIRADDFR MGGQSFLAEQ
     GKDKDWGVPA GARDLKFEFT TQAGELVTLD VLAKDGDDIE ELATYINGQT DKLKASVDQD
     GKLQIFAAEP NLQGDLAISG GLATELGLNG GPGVKTTVQD IDITSVGGSQ NAVGVLDAAL
     RYVDSQRAEL GAKQNRLSHS INNLANIQEN VEASNSRIKD TDFAKETTQM TKAQILQQAG
     TSILAQAKQL PNSAMSLLQ