ID   FLAA_VIBCH              Reviewed;         379 AA.
AC   P0C6C3; O30858; O34220;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Flagellin A;
DE   AltName: Full=Flagellin core protein;
GN   Name=flaA; OrderedLocusNames=VC_2188;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=El Tor Inaba V86;
RX   PubMed=9742694; DOI=10.1111/j.1574-6968.1998.tb13152.x;
RA   Das M., Chopra A.K., Wood T., Peterson J.W.;
RT   "Cloning, sequencing and expression of the flagellin core protein and other
RT   genes encoding structural proteins of the Vibrio cholerae flagellum.";
RL   FEMS Microbiol. Lett. 165:239-246(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: Flagellin is the subunit protein which polymerizes to form
CC       the filaments of bacterial flagella. FlaA is required to form a core or
CC       scaffold into which the other flagellins are inserted to provide
CC       structural integrity. Essential for flagellar synthesis and motility;
CC       important for full virulence.
CC   -!- SUBUNIT: Heteromer of multiple flagellin subunits including FlaA, FlaB,
CC       FlaC, FlaD and FlaE.
CC   -!- SUBCELLULAR LOCATION: Secreted. Bacterial flagellum.
CC   -!- MISCELLANEOUS: V.cholerae is able to differentially regulate the
CC       flagellins within the flagellum maybe to produce flagella which are
CC       particularly suited for motility within a given environment. A
CC       flagellar filament composed exclusively of FlaA is fragile and easily
CC       broken.
CC   -!- SIMILARITY: Belongs to the bacterial flagellin family. {ECO:0000305}.
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DR   EMBL; AF019213; AAC33160.1; -; Genomic_DNA.
DR   EMBL; AE003852; AAF95333.1; -; Genomic_DNA.
DR   PIR; G82107; G82107.
DR   RefSeq; NP_231819.1; NC_002505.1.
DR   RefSeq; WP_000154827.1; NZ_LT906614.1.
DR   AlphaFoldDB; P0C6C3; -.
DR   SMR; P0C6C3; -.
DR   STRING; 243277.VC_2188; -.
DR   PRIDE; P0C6C3; -.
DR   DNASU; 2613228; -.
DR   EnsemblBacteria; AAF95333; AAF95333; VC_2188.
DR   KEGG; vch:VC_2188; -.
DR   PATRIC; fig|243277.26.peg.2086; -.
DR   eggNOG; COG1344; Bacteria.
DR   HOGENOM; CLU_011142_7_1_6; -.
DR   OMA; ITHNQIA; -.
DR   BioCyc; VCHO:VC2188-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0009288; C:bacterial-type flagellum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 6.10.10.10; -; 1.
DR   InterPro; IPR001492; Flagellin.
DR   InterPro; IPR046358; Flagellin_C.
DR   InterPro; IPR042187; Flagellin_C_sub2.
DR   InterPro; IPR010810; Flagellin_hook_IN_motif.
DR   InterPro; IPR001029; Flagellin_N.
DR   PANTHER; PTHR42792; PTHR42792; 1.
DR   Pfam; PF00700; Flagellin_C; 1.
DR   Pfam; PF07196; Flagellin_IN; 1.
DR   Pfam; PF00669; Flagellin_N; 1.
DR   PRINTS; PR00207; FLAGELLIN.
PE   3: Inferred from homology;
KW   Bacterial flagellum; Coiled coil; Reference proteome; Secreted; Virulence.
FT   CHAIN           1..379
FT                   /note="Flagellin A"
FT                   /id="PRO_0000182648"
FT   COILED          104..129
FT                   /evidence="ECO:0000255"
FT   COILED          314..341
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   379 AA;  40383 MW;  0E7AD5916BD05784 CRC64;
     MTINVNTNVS AMTAQRYLTK ATGELNTSME RLSSGNRINS AKDDAAGLQI SNRLTAQSRG
     LDVAMRNAND GISIAQTAEG AMNESTSILQ RMRDLALQSA NGTNSASERQ ALNEESVALQ
     DELNRIAETT SFGGRKLLNG SFGEASFQIG SSSGEAIIMG LTSVRADDFR MGGQSFIAEQ
     PKTKEWGVPP TARDLKFEFT KKDGEAVVLD IIAKDGDDIE ELATYINGQT DLFKASVDQE
     GKLQIFVAEP NIEGNFNISG GLATELGLNG GPGVKTTVQD IDITSVGGSQ NAVGIIDAAL
     KYVDSQRADL GAKQNRLSHS ISNLSNIQEN VEASKSRIKD TDFAKETTQL TKSQILQQAG
     TSILAQAKQL PNSAISLLQ