ID   FLAB1_TREPA             Reviewed;         286 AA.
AC   P21990;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   25-MAY-2022, entry version 137.
DE   RecName: Full=Flagellin FlaB1 {ECO:0000305};
DE   AltName: Full=Class B;
DE   AltName: Full=Flagellar filament 34.5 kDa core protein {ECO:0000303|PubMed:2187805};
GN   Name=flaB1; OrderedLocusNames=TP_0868;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=2187805; DOI=10.1128/iai.58.6.1697-1704.1990;
RA   Champion C.I., Miller J.N., Lovett M.A., Blanco D.R.;
RT   "Cloning, sequencing, and expression of two class B endoflagellar genes of
RT   Treponema pallidum subsp. pallidum encoding the 34.5- and 31.0-kilodalton
RT   proteins.";
RL   Infect. Immun. 58:1697-1704(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
RN   [3]
RP   PROTEIN SEQUENCE OF 1-20.
RX   PubMed=3045083; DOI=10.1128/jb.170.9.4072-4082.1988;
RA   Norris S.J., Charon N.W., Cook R.G., Fuentes M.D., Limberger R.J.;
RT   "Antigenic relatedness and N-terminal sequence homology define two classes
RT   of periplasmic flagellar proteins of Treponema pallidum subsp. pallidum and
RT   Treponema phagedenis.";
RL   J. Bacteriol. 170:4072-4082(1988).
RN   [4]
RP   INTERACTION WITH FLIW, AND MUTAGENESIS OF ILE-233 AND ASN-237.
RC   STRAIN=Nichols;
RX   PubMed=16936039; DOI=10.1128/jb.00820-06;
RA   Titz B., Rajagopala S.V., Ester C., Haeuser R., Uetz P.;
RT   "Novel conserved assembly factor of the bacterial flagellum.";
RL   J. Bacteriol. 188:7700-7706(2006).
CC   -!- FUNCTION: Component of the core of the flagella.
CC   -!- SUBUNIT: The flagellum consists of an outer layer composed of repeating
CC       units of FlaA around a core that contains several antigenically related
CC       polypeptides. Interacts via its C-terminus with FliW; a synthetic
CC       peptide of residues 229-247 partially blocks binding to FliW
CC       (PubMed:16936039). {ECO:0000269|PubMed:16936039}.
CC   -!- SUBCELLULAR LOCATION: Periplasmic flagellum. Periplasm.
CC   -!- SIMILARITY: Belongs to the bacterial flagellin family. {ECO:0000305}.
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DR   EMBL; X63965; CAA45381.1; -; Genomic_DNA.
DR   EMBL; AE000520; AAC65834.1; -; Genomic_DNA.
DR   PIR; B41489; B41489.
DR   RefSeq; WP_010882311.1; NC_021490.2.
DR   AlphaFoldDB; P21990; -.
DR   SMR; P21990; -.
DR   IntAct; P21990; 4.
DR   STRING; 243276.TPANIC_0868; -.
DR   PRIDE; P21990; -.
DR   EnsemblBacteria; AAC65834; AAC65834; TP_0868.
DR   GeneID; 57879383; -.
DR   KEGG; tpa:TP_0868; -.
DR   eggNOG; COG1344; Bacteria.
DR   HOGENOM; CLU_011142_2_0_12; -.
DR   OMA; IASQTTY; -.
DR   OrthoDB; 636786at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0055040; C:periplasmic flagellum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 6.10.10.10; -; 1.
DR   InterPro; IPR001492; Flagellin.
DR   InterPro; IPR046358; Flagellin_C.
DR   InterPro; IPR042187; Flagellin_C_sub2.
DR   InterPro; IPR001029; Flagellin_N.
DR   PANTHER; PTHR42792; PTHR42792; 1.
DR   Pfam; PF00700; Flagellin_C; 1.
DR   Pfam; PF00669; Flagellin_N; 1.
DR   PRINTS; PR00207; FLAGELLIN.
PE   1: Evidence at protein level;
KW   Bacterial flagellum; Direct protein sequencing; Periplasm;
KW   Reference proteome.
FT   CHAIN           1..286
FT                   /note="Flagellin FlaB1"
FT                   /id="PRO_0000182634"
FT   REGION          231..286
FT                   /note="Required for interaction with FliW"
FT                   /evidence="ECO:0000269|PubMed:16936039"
FT   MUTAGEN         233
FT                   /note="I->A: Peptide of residues 229-247 no longer binds
FT                   FliW."
FT                   /evidence="ECO:0000269|PubMed:16936039"
FT   MUTAGEN         237
FT                   /note="N->A: Peptide of residues 229-247 no longer binds
FT                   FliW."
FT                   /evidence="ECO:0000269|PubMed:16936039"
SQ   SEQUENCE   286 AA;  31174 MW;  E2D8C13B052C5CF8 CRC64;
     MIINHNMSAM FAQRTLGHTN VQVGKGIEKL SSGYRINRAG DDASGLAVSE KMRSQIRGLN
     QASTNASNGV NFIQVTEAYL QETTDIMQRI RELAIQAANG IYSAEDRMQI QVEVSQLVAE
     VDRIASSAQF NGMNLLTGRF SRTEGENVIG GSMWFHIGAN MDQRMRVYIG TMTAVALGVR
     NGVDESIMSI ETADSANKSI GTIDAALKRI NKQRADLGGY QNRMEYTVVG LDIAAENLQA
     AESRIRDANI AKQMVEYTKN QVLTQSGTAM LAQANTSAQS ILSILR