ID   FLAB2_TREPA             Reviewed;         286 AA.
AC   P21991;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 2.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Flagellin FlaB2 {ECO:0000305};
DE   AltName: Full=Class B;
DE   AltName: Full=Flagellar filament 33 kDa core protein;
GN   Name=flaB2 {ECO:0000303|PubMed:2659537}; OrderedLocusNames=TP_0792;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2659537; DOI=10.1128/iai.57.7.2166-2172.1989;
RA   Pallesen L., Hindersson P.;
RT   "Cloning and sequencing of a Treponema pallidum gene encoding a 31.3-
RT   kilodalton endoflagellar subunit (FlaB2).";
RL   Infect. Immun. 57:2166-2172(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
RN   [3]
RP   PROTEIN SEQUENCE OF 1-21.
RX   PubMed=3045083; DOI=10.1128/jb.170.9.4072-4082.1988;
RA   Norris S.J., Charon N.W., Cook R.G., Fuentes M.D., Limberger R.J.;
RT   "Antigenic relatedness and N-terminal sequence homology define two classes
RT   of periplasmic flagellar proteins of Treponema pallidum subsp. pallidum and
RT   Treponema phagedenis.";
RL   J. Bacteriol. 170:4072-4082(1988).
RN   [4]
RP   PROTEIN SEQUENCE OF 1-20.
RX   PubMed=2447018; DOI=10.1128/iai.56.1.168-175.1988;
RA   Blanco D.R., Champion C.I., Miller J.N., Lovett M.A.;
RT   "Antigenic and structural characterization of Treponema pallidum (Nichols
RT   strain) endoflagella.";
RL   Infect. Immun. 56:168-175(1988).
RN   [5]
RP   INTERACTION WITH FLIW.
RC   STRAIN=Nichols;
RX   PubMed=16936039; DOI=10.1128/jb.00820-06;
RA   Titz B., Rajagopala S.V., Ester C., Haeuser R., Uetz P.;
RT   "Novel conserved assembly factor of the bacterial flagellum.";
RL   J. Bacteriol. 188:7700-7706(2006).
CC   -!- FUNCTION: Component of the core of the flagella.
CC   -!- SUBUNIT: The flagellum consists of an outer layer composed of repeating
CC       units of FlaA around a core that contains several antigenically related
CC       polypeptides. Interacts with FliW; a synthetic peptide of FlaB1
CC       (residues 229-247) partially blocks binding of this protein to FliW
CC       (PubMed:16936039). {ECO:0000269|PubMed:16936039}.
CC   -!- SUBCELLULAR LOCATION: Periplasmic flagellum. Periplasm.
CC   -!- SIMILARITY: Belongs to the bacterial flagellin family. {ECO:0000305}.
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DR   EMBL; AE000520; AAC65757.1; -; Genomic_DNA.
DR   PIR; A37053; A37053.
DR   RefSeq; WP_010882237.1; NC_021490.2.
DR   AlphaFoldDB; P21991; -.
DR   SMR; P21991; -.
DR   IntAct; P21991; 6.
DR   STRING; 243276.TPANIC_0792; -.
DR   PRIDE; P21991; -.
DR   EnsemblBacteria; AAC65757; AAC65757; TP_0792.
DR   GeneID; 57879313; -.
DR   KEGG; tpa:TP_0792; -.
DR   eggNOG; COG1344; Bacteria.
DR   HOGENOM; CLU_011142_2_0_12; -.
DR   OMA; FEHTINN; -.
DR   OrthoDB; 636786at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0055040; C:periplasmic flagellum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 6.10.10.10; -; 1.
DR   InterPro; IPR001492; Flagellin.
DR   InterPro; IPR046358; Flagellin_C.
DR   InterPro; IPR042187; Flagellin_C_sub2.
DR   InterPro; IPR001029; Flagellin_N.
DR   PANTHER; PTHR42792; PTHR42792; 1.
DR   Pfam; PF00700; Flagellin_C; 1.
DR   Pfam; PF00669; Flagellin_N; 1.
DR   PRINTS; PR00207; FLAGELLIN.
PE   1: Evidence at protein level;
KW   Bacterial flagellum; Direct protein sequencing; Periplasm;
KW   Reference proteome.
FT   CHAIN           1..286
FT                   /note="Flagellin FlaB2"
FT                   /id="PRO_0000182635"
SQ   SEQUENCE   286 AA;  31347 MW;  650BA1B2260DEDB2 CRC64;
     MIINHNMSAM FSQRTLGHTN LSVQKNIEKL SSGLRINRSG DDASGLAVSE KMRSQIRGLN
     QASTNAQNGI SFIQVAEAFL QETTDVIQRI RELSVQAANG IYSAEDRLYI QVEVSQLVAE
     VDRIASHAQF NGMNMLTGRF ARQGGENTVT ASMWFHIGAN MDQRTRAYIG TMTAVAMGIR
     DAGDESVMNI DSPEKANRAI GTLDQAIKRI NKQRADLGAY QNRLDHTVAG INVAAENLQA
     AESRIRDVDM AKEMVDYTKN QILVQSGTAM LAQANQATQS VLSLLR