AKR1_SOYBN
ID AKR1_SOYBN Reviewed; 346 AA.
AC C6TBN2; C0JRE4;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 1.
DT 03-AUG-2022, entry version 43.
DE RecName: Full=Probable aldo-keto reductase 1;
DE Short=GmAKR1;
DE EC=1.1.1.-;
GN Name=AKR1;
OS Glycine max (Soybean) (Glycine hispida).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Glycine;
OC Glycine subgen. Soja.
OX NCBI_TaxID=3847;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Cheung F., Xiao Y., Chan A., Moskal W., Town C.D.;
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 26-346, INDUCTION, TISSUE SPECIFICITY,
RP DEVELOPMENTAL STAGE, AND FUNCTION.
RC STRAIN=cv. Shinpaldal;
RX PubMed=19277505; DOI=10.1007/s10059-009-0027-x;
RA Hur Y.S., Shin K.H., Kim S., Nam K.H., Lee M.S., Chun J.Y., Cheon C.I.;
RT "Overexpression of GmAKR1, a stress-induced aldo/keto reductase from
RT soybean, retards nodule development.";
RL Mol. Cells 27:217-223(2009).
CC -!- FUNCTION: May interfere with the nodulation process and inhibits nodule
CC development. {ECO:0000269|PubMed:19277505}.
CC -!- TISSUE SPECIFICITY: Expressed in roots. Detected in leaves, stems and
CC mature nodules. {ECO:0000269|PubMed:19277505}.
CC -!- DEVELOPMENTAL STAGE: Down-regulated as the nodules mature.
CC {ECO:0000269|PubMed:19277505}.
CC -!- INDUCTION: Not induced by auxin. Up-regulated in leaves by ethylene and
CC salt stress. Down-regulated by abscisic acid.
CC {ECO:0000269|PubMed:19277505}.
CC -!- SIMILARITY: Belongs to the aldo/keto reductase 13 family.
CC {ECO:0000305}.
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DR EMBL; BT094946; ACU19234.1; -; mRNA.
DR EMBL; FJ430074; ACN56468.1; -; mRNA.
DR RefSeq; NP_001236007.1; NM_001249078.1.
DR AlphaFoldDB; C6TBN2; -.
DR SMR; C6TBN2; -.
DR STRING; 3847.GLYMA03G40860.1; -.
DR PRIDE; C6TBN2; -.
DR GeneID; 100301897; -.
DR KEGG; gmx:100301897; -.
DR eggNOG; KOG1575; Eukaryota.
DR InParanoid; C6TBN2; -.
DR OrthoDB; 1136766at2759; -.
DR Proteomes; UP000008827; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004033; F:aldo-keto reductase (NADP) activity; IBA:GO_Central.
DR Gene3D; 3.20.20.100; -; 1.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR SUPFAM; SSF51430; SSF51430; 1.
PE 2: Evidence at transcript level;
KW NADP; Oxidoreductase; Reference proteome.
FT CHAIN 1..346
FT /note="Probable aldo-keto reductase 1"
FT /id="PRO_0000415752"
FT ACT_SITE 62
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT BINDING 130
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 209..218
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT CONFLICT 102
FT /note="E -> K (in Ref. 2; ACN56468)"
FT /evidence="ECO:0000305"
FT CONFLICT 114..115
FT /note="TG -> AS (in Ref. 2; ACN56468)"
FT /evidence="ECO:0000305"
FT CONFLICT 130
FT /note="H -> R (in Ref. 2; ACN56468)"
FT /evidence="ECO:0000305"
FT CONFLICT 310
FT /note="F -> S (in Ref. 2; ACN56468)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 346 AA; 38253 MW; 8A17BCEF80DCB5C1 CRC64;
MTQAQIQPVK LGTQGFEVSK LGFGCMGLTG AYNDPLQEQD GISVIKYAFS KGITFFDTAD
VYGANANELL VGKALKQLPR EKIQIATKFG IASRGFPDMK IEGSPEYVRS CCETGLKRLD
VEYIDLYYQH RVDTSVPIEE TVGELKKLVE EGKVKYIGLS EASPDTIRRA HAIHPITAVQ
IEWSLWTRDI EEEIVPLCRE LGIGIVPYSP LGRGFFGGKG VVENVPTNSS LKAHPRFQAE
NLDKNKNIYE RIEGLAKKHQ ATPAQLALAW VLQQGEDVVP IPGTTKIKNL DQNIGALAVK
LSEKDLREIF EAVPIGDVAG GRYYNGLDHF SWKYANTPPK DSKIST
