ID   FLAB3_TREPA             Reviewed;         285 AA.
AC   P21992; O83840;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 3.
DT   25-MAY-2022, entry version 143.
DE   RecName: Full=Flagellin FlaB3 {ECO:0000305};
DE   AltName: Full=Class B;
DE   AltName: Full=Flagellar filament 31 kDa core protein {ECO:0000303|PubMed:2187805};
GN   Name=flaB3; OrderedLocusNames=TP_0870;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=2187805; DOI=10.1128/iai.58.6.1697-1704.1990;
RA   Champion C.I., Miller J.N., Lovett M.A., Blanco D.R.;
RT   "Cloning, sequencing, and expression of two class B endoflagellar genes of
RT   Treponema pallidum subsp. pallidum encoding the 34.5- and 31.0-kilodalton
RT   proteins.";
RL   Infect. Immun. 58:1697-1704(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
RN   [3]
RP   PROTEIN SEQUENCE OF 1-30.
RX   PubMed=3045083; DOI=10.1128/jb.170.9.4072-4082.1988;
RA   Norris S.J., Charon N.W., Cook R.G., Fuentes M.D., Limberger R.J.;
RT   "Antigenic relatedness and N-terminal sequence homology define two classes
RT   of periplasmic flagellar proteins of Treponema pallidum subsp. pallidum and
RT   Treponema phagedenis.";
RL   J. Bacteriol. 170:4072-4082(1988).
RN   [4]
RP   INTERACTION WITH FLIW.
RC   STRAIN=Nichols;
RX   PubMed=16936039; DOI=10.1128/jb.00820-06;
RA   Titz B., Rajagopala S.V., Ester C., Haeuser R., Uetz P.;
RT   "Novel conserved assembly factor of the bacterial flagellum.";
RL   J. Bacteriol. 188:7700-7706(2006).
CC   -!- FUNCTION: Component of the core of the flagella.
CC   -!- SUBUNIT: The flagellum consists of an outer layer composed of repeating
CC       units of FlaA around a core that contains several antigenically related
CC       polypeptides. Interacts with FliW; a synthetic peptide of FlaB1
CC       (residues 229-247) partially blocks binding of this protein to FliW
CC       (PubMed:16936039). {ECO:0000269|PubMed:16936039}.
CC   -!- SUBCELLULAR LOCATION: Periplasmic flagellum. Periplasm.
CC   -!- SIMILARITY: Belongs to the bacterial flagellin family. {ECO:0000305}.
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DR   EMBL; X63965; CAA45382.1; -; Genomic_DNA.
DR   EMBL; AE000520; AAC65835.1; -; Genomic_DNA.
DR   PIR; A41489; A41489.
DR   RefSeq; WP_010882313.1; NC_021490.2.
DR   AlphaFoldDB; P21992; -.
DR   SMR; P21992; -.
DR   IntAct; P21992; 100.
DR   STRING; 243276.TPANIC_0870; -.
DR   EnsemblBacteria; AAC65835; AAC65835; TP_0870.
DR   GeneID; 57879385; -.
DR   KEGG; tpa:TP_0870; -.
DR   eggNOG; COG1344; Bacteria.
DR   HOGENOM; CLU_011142_2_0_12; -.
DR   OMA; ENEKRMN; -.
DR   OrthoDB; 636786at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0055040; C:periplasmic flagellum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 6.10.10.10; -; 1.
DR   InterPro; IPR001492; Flagellin.
DR   InterPro; IPR046358; Flagellin_C.
DR   InterPro; IPR042187; Flagellin_C_sub2.
DR   InterPro; IPR001029; Flagellin_N.
DR   PANTHER; PTHR42792; PTHR42792; 1.
DR   Pfam; PF00700; Flagellin_C; 1.
DR   Pfam; PF00669; Flagellin_N; 1.
DR   PRINTS; PR00207; FLAGELLIN.
PE   1: Evidence at protein level;
KW   Bacterial flagellum; Direct protein sequencing; Periplasm;
KW   Reference proteome.
FT   CHAIN           1..285
FT                   /note="Flagellin FlaB3"
FT                   /id="PRO_0000182636"
FT   CONFLICT        251..252
FT                   /note="QQ -> HE (in Ref. 1; CAA45382)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   285 AA;  31055 MW;  CB75EBCFDE8B1244 CRC64;
     MIINHNMSAM FAQRQGGING LAIAKNIEKL SSGYRINRAG DDASGLAVSE KMRSQIRGLN
     QAGQNIQNGI SFIQATEGYL AETTEIVQRL RELAIQAANG IYSAEDRMQI QVEVSQLVDE
     VDRIASQAQF NGMNLLTGRF SRESALGPMQ LHVGANMDQN EKIFINTMTA SALGFFSDEG
     TDGSRSISIA TVDGANKVIG TLDSALKEIN KQRADLGAYQ NRFETAYQGI AIAAENLQAA
     ESRIRDADLA QQMVDYTKNQ ILEQSTMAML AQANTQPQAV LRLMQ