FLAB_HELPY
ID FLAB_HELPY Reviewed; 514 AA.
AC Q07911;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 4.
DT 25-MAY-2022, entry version 127.
DE RecName: Full=Flagellin B;
DE AltName: Full=Flagellin N;
GN Name=flaB; OrderedLocusNames=HP_0115;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=85P;
RX PubMed=8501031; DOI=10.1128/jb.175.11.3278-3288.1993;
RA Suerbaum S., Josenhans C., Labigne A.;
RT "Cloning and genetic characterization of the Helicobacter pylori and
RT Helicobacter mustelae flaB flagellin genes and construction of H. pylori
RT flaA- and flaB-negative mutants by electroporation-mediated allelic
RT exchange.";
RL J. Bacteriol. 175:3278-3288(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
RN [3]
RP PROTEIN SEQUENCE OF 2-21.
RC STRAIN=NTCC 11637 / Isolate 915;
RX PubMed=1704004; DOI=10.1128/jb.173.3.937-946.1991;
RA Kostrzynska M., Betts J.D., Austin J.W., Trust T.J.;
RT "Identification, characterization, and spatial localization of two
RT flagellin species in Helicobacter pylori flagella.";
RL J. Bacteriol. 173:937-946(1991).
CC -!- FUNCTION: Flagellin is the subunit protein which polymerizes to form
CC the filaments of bacterial flagella. Important for motility and
CC virulence.
CC -!- SUBUNIT: Heteromer of FlaA and FlaB. FlaB is located proximal to the
CC hook while the remainder of the filament is composed of the predominant
CC FlaA.
CC -!- INTERACTION:
CC Q07911; O25448: HP_0753; NbExp=3; IntAct=EBI-7500186, EBI-7499990;
CC -!- SUBCELLULAR LOCATION: Secreted. Bacterial flagellum.
CC -!- SIMILARITY: Belongs to the bacterial flagellin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L08907; AAA25016.1; -; Genomic_DNA.
DR EMBL; AE000511; AAD07183.1; -; Genomic_DNA.
DR PIR; C64534; C64534.
DR RefSeq; NP_206915.1; NC_000915.1.
DR RefSeq; WP_000010001.1; NC_000915.1.
DR PDB; 6LEA; X-ray; 2.95 A; E/F=416-514.
DR PDBsum; 6LEA; -.
DR AlphaFoldDB; Q07911; -.
DR SMR; Q07911; -.
DR DIP; DIP-3194N; -.
DR IntAct; Q07911; 3.
DR MINT; Q07911; -.
DR STRING; 85962.C694_00570; -.
DR PaxDb; Q07911; -.
DR EnsemblBacteria; AAD07183; AAD07183; HP_0115.
DR KEGG; hpy:HP_0115; -.
DR PATRIC; fig|85962.8.peg.122; -.
DR eggNOG; COG1344; Bacteria.
DR OMA; IASQTTY; -.
DR PhylomeDB; Q07911; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0009288; C:bacterial-type flagellum; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 6.10.10.10; -; 1.
DR InterPro; IPR001492; Flagellin.
DR InterPro; IPR046358; Flagellin_C.
DR InterPro; IPR042187; Flagellin_C_sub2.
DR InterPro; IPR010810; Flagellin_hook_IN_motif.
DR InterPro; IPR001029; Flagellin_N.
DR PANTHER; PTHR42792; PTHR42792; 1.
DR Pfam; PF00700; Flagellin_C; 1.
DR Pfam; PF07196; Flagellin_IN; 2.
DR Pfam; PF00669; Flagellin_N; 1.
DR PRINTS; PR00207; FLAGELLIN.
PE 1: Evidence at protein level;
KW 3D-structure; Bacterial flagellum; Direct protein sequencing;
KW Reference proteome; Secreted; Virulence.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:1704004"
FT CHAIN 2..514
FT /note="Flagellin B"
FT /id="PRO_0000182612"
FT VARIANT 155
FT /note="A -> T (in strain: 85P)"
FT VARIANT 182
FT /note="A -> E (in strain: 85P)"
FT VARIANT 190..191
FT /note="AQ -> GA (in strain: 85P)"
FT VARIANT 335
FT /note="A -> T (in strain: 85P)"
FT HELIX 478..483
FT /evidence="ECO:0007829|PDB:6LEA"
FT HELIX 487..491
FT /evidence="ECO:0007829|PDB:6LEA"
FT STRAND 493..495
FT /evidence="ECO:0007829|PDB:6LEA"
FT HELIX 497..501
FT /evidence="ECO:0007829|PDB:6LEA"
FT HELIX 506..513
FT /evidence="ECO:0007829|PDB:6LEA"
SQ SEQUENCE 514 AA; 53882 MW; 1E3D0728BD14A584 CRC64;
MSFRINTNIA ALTSHAVGVQ NNRDLSSSLE KLSSGLRINK AADDSSGMAI ADSLRSQSAN
LGQAIRNAND AIGMVQTADK AMDEQIKILD TIKTKAVQAA QDGQTLESRR ALQSDIQRLL
EELDNIANTT SFNGQQMLSG SFSNKEFQIG AYSNATVKAS IGSTSSDKIG HVRMETSSFS
GAGMLASAAA QNLTEVGLNF KQVNGVNDYK IETVRISTSA GTGIGALSEI INRFSNTLGV
RASYNVMATG GTPVQSGTVR ELTINGVEIG TVNDVHKNDA DGRLTNAINS VKDRTGVEAS
LDIQGRINLH SIDGRAISVH AASASGQVFG GGNFAGISGT QHAVIGRLTL TRTDARDIIV
SGVNFSHVGF HSAQGVAEYT VNLRAVRGIF DANVASAAGA NANGAQAETN SQGIGAGVTS
LKGAMIVMDM ADSARTQLDK IRSDMGSVQM ELVTTINNIS VTQVNVKAAE SQIRDVDFAE
ESANFSKYNI LAQSGSFAMA QANAVQQNVL RLLQ
