FLAB_LEPIN
ID FLAB_LEPIN Reviewed; 283 AA.
AC O51941;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2002, sequence version 2.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=Flagellar filament 35 kDa core protein;
DE AltName: Full=35 kDa antigen;
DE AltName: Full=Flagellin class B;
GN Name=flaB; Synonyms=flaB2; OrderedLocusNames=LA_2019;
OS Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS 56601).
OC Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptospira.
OX NCBI_TaxID=189518;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-13.
RC STRAIN=Serogroup Pomona;
RX PubMed=9317049; DOI=10.1128/iai.65.10.4355-4359.1997;
RA Lin M., Surujballi O., Nielsen K., Nadin-Davis S., Randall G.;
RT "Identification of a 35-kilodalton serovar-cross-reactive flagellar
RT protein, FlaB, from Leptospira interrogans by N-terminal sequencing, gene
RT cloning, and sequence analysis.";
RL Infect. Immun. 65:4355-4359(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=56601;
RX PubMed=12712204; DOI=10.1038/nature01597;
RA Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H., Zhang Y.-X.,
RA Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F., Jiang J.-X.,
RA Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H., Yin H.-F., Zhang Y., Zhu G.-F.,
RA Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W., Yao Z.-J., Shen Y.,
RA Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A., Saint Girons I.,
RA Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z., Xu J.-G., Zhao G.-P.;
RT "Unique physiological and pathogenic features of Leptospira interrogans
RT revealed by whole-genome sequencing.";
RL Nature 422:888-893(2003).
CC -!- FUNCTION: Component of the core of the flagella. {ECO:0000305}.
CC -!- SUBUNIT: The flagellum consists of two outer layers around a core that
CC contains several antigenically related polypeptides.
CC -!- SUBCELLULAR LOCATION: Periplasmic flagellum. Periplasm.
CC -!- SIMILARITY: Belongs to the bacterial flagellin family. {ECO:0000305}.
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DR EMBL; AF014114; AAB94024.1; -; Genomic_DNA.
DR EMBL; AE010300; AAN49218.1; -; Genomic_DNA.
DR RefSeq; NP_712200.1; NC_004342.2.
DR RefSeq; WP_000586168.1; NC_004342.2.
DR AlphaFoldDB; O51941; -.
DR SMR; O51941; -.
DR STRING; 189518.LA_2019; -.
DR EnsemblBacteria; AAN49218; AAN49218; LA_2019.
DR KEGG; lil:LA_2019; -.
DR PATRIC; fig|189518.3.peg.2015; -.
DR HOGENOM; CLU_011142_2_0_12; -.
DR InParanoid; O51941; -.
DR OMA; NGVASQH; -.
DR Proteomes; UP000001408; Chromosome I.
DR GO; GO:0055040; C:periplasmic flagellum; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 6.10.10.10; -; 1.
DR InterPro; IPR001492; Flagellin.
DR InterPro; IPR046358; Flagellin_C.
DR InterPro; IPR042187; Flagellin_C_sub2.
DR InterPro; IPR001029; Flagellin_N.
DR PANTHER; PTHR42792; PTHR42792; 1.
DR Pfam; PF00700; Flagellin_C; 1.
DR Pfam; PF00669; Flagellin_N; 1.
DR PRINTS; PR00207; FLAGELLIN.
PE 1: Evidence at protein level;
KW Bacterial flagellum; Direct protein sequencing; Periplasm;
KW Reference proteome.
FT CHAIN 1..283
FT /note="Flagellar filament 35 kDa core protein"
FT /id="PRO_0000182616"
FT CONFLICT 56
FT /note="I -> V (in Ref. 1; AAB94024)"
FT /evidence="ECO:0000305"
FT CONFLICT 268
FT /note="Q -> R (in Ref. 1; AAB94024)"
FT /evidence="ECO:0000305"
FT CONFLICT 282
FT /note="Q -> H (in Ref. 1; AAB94024)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 283 AA; 31272 MW; 0C1ED44A7057F856 CRC64;
MIINHNLSAV NAHRSLKFNE LAVDKTMKAL SSGMRINSAA DDASGLAVSE KLRTQINGLR
QAERNTEDGM SFIQTAEGFL EQTSNIIQRI RVLAIQTSNG IYSNEDRQLV QVEVSALVDE
VDRIASQAEF NKFKLFEGQF ARGSRVASMW FHMGPNQNQR ERFYIGTMTS KALKLVKADG
RPIAISSPGE ANDVIGLADA ALTKIMKQRA DMGAYYNRLE YTAKGLMGAY ENMQASESRI
RDADMAEEVV SLTTKQILVQ SGTAMLAQAN MKPNSVLKLL QQI