ID   FLAC_CAMJE              Reviewed;         249 AA.
AC   P96747; Q0PAF9; Q9PPI7;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Secreted flagellin C;
GN   Name=flaC; OrderedLocusNames=Cj0720c;
OS   Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC
OS   11168).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=192222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Chan V.L., Louie H., Ng D., Bingham H.L.;
RT   "A third flagellin gene (flaC) of Campylobacter jejuni.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700819 / NCTC 11168;
RX   PubMed=10688204; DOI=10.1038/35001088;
RA   Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M.,
RA   Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S.,
RA   Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A.,
RA   Rajandream M.A., Rutherford K.M., van Vliet A.H.M., Whitehead S.,
RA   Barrell B.G.;
RT   "The genome sequence of the food-borne pathogen Campylobacter jejuni
RT   reveals hypervariable sequences.";
RL   Nature 403:665-668(2000).
RN   [3]
RP   FUNCTION, SUBCELLULAR LOCATION, POST-TRANSLATIONAL MODIFICATION, AND
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 43431 / TGH 9011;
RX   PubMed=15228533; DOI=10.1111/j.1365-2958.2004.04175.x;
RA   Song Y.C., Jin S., Louie H., Ng D., Lau R., Zhang Y., Weerasekera R.,
RA   Al Rashid S., Ward L.A., Der S.D., Chan V.L.;
RT   "FlaC, a protein of Campylobacter jejuni TGH9011 (ATCC43431) secreted
RT   through the flagellar apparatus, binds epithelial cells and influences cell
RT   invasion.";
RL   Mol. Microbiol. 53:541-553(2004).
CC   -!- FUNCTION: Plays a role in virulence. {ECO:0000269|PubMed:15228533}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15228533}. Note=Not
CC       detected in flagellar preparations, requires the flagellar export
CC       apparatus (FlgF) for secretion. {ECO:0000269|PubMed:15228533}.
CC   -!- SUBCELLULAR LOCATION: Host cell surface {ECO:0000305|PubMed:15228533}.
CC       Note=(Microbial infection) Binds to the surface of human HEp2 (ATCC
CC       CCL-23) cells. {ECO:0000269|PubMed:15228533}.
CC   -!- PTM: The secreted form is about 1 kDa larger than the whole cell lysate
CC       form, presumably due to post-translational modification. A 22 kDa form
CC       is also found in the secreted fraction, probably resulting from
CC       proteolysis. {ECO:0000269|PubMed:15228533}.
CC   -!- DISRUPTION PHENOTYPE: No visible effect on flagellar structure, cell
CC       shape or motility. Adheres to host epithelial cells (human HEp2) but
CC       invades less well (14% suriving bacteria, determined by bacterial
CC       counts from lysed cells after 2 hours of gentamicin treatment).
CC       {ECO:0000269|PubMed:15228533}.
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DR   EMBL; U85622; AAB48473.1; -; Genomic_DNA.
DR   EMBL; AL111168; CAL34857.1; -; Genomic_DNA.
DR   PIR; C81343; C81343.
DR   RefSeq; WP_002858476.1; NC_002163.1.
DR   RefSeq; YP_002344138.1; NC_002163.1.
DR   AlphaFoldDB; P96747; -.
DR   SMR; P96747; -.
DR   IntAct; P96747; 149.
DR   STRING; 192222.Cj0720c; -.
DR   PaxDb; P96747; -.
DR   EnsemblBacteria; CAL34857; CAL34857; Cj0720c.
DR   GeneID; 905038; -.
DR   KEGG; cje:Cj0720c; -.
DR   PATRIC; fig|192222.6.peg.712; -.
DR   eggNOG; COG1344; Bacteria.
DR   HOGENOM; CLU_097077_0_0_7; -.
DR   OMA; MWAIRYL; -.
DR   Proteomes; UP000000799; Chromosome.
DR   GO; GO:0009288; C:bacterial-type flagellum; IEA:InterPro.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0044228; C:host cell surface; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR001492; Flagellin.
DR   InterPro; IPR001029; Flagellin_N.
DR   PANTHER; PTHR42792; PTHR42792; 2.
DR   Pfam; PF00669; Flagellin_N; 1.
PE   4: Predicted;
KW   Reference proteome; Secreted; Virulence.
FT   CHAIN           1..249
FT                   /note="Secreted flagellin C"
FT                   /id="PRO_0000182599"
FT   CONFLICT        161
FT                   /note="S -> N (in Ref. 1; AAB48473)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   249 AA;  26606 MW;  D233CE46547D4112 CRC64;
     MMISDATMMQ QNYYLNNAQK ASDKALENIA AVRAISGVDS ANLAIADSLR SQSSTIDQGV
     ANAYDAIGVL QIADASLTNI SQSADRLNEL SVKMNNAALN DSQKGMLRTE ATRIQESIND
     SFNNATYNGK NVFQTMNFVV GSGTETTNLN PLATDGLSID SQDSITNFMD QLGSLRSEIG
     SGINAITSNI NASVQNSINS KAAENNLLNN DMAKNVNDFN ANYLKENAAA FVAAQSNMQL
     QSKIANLLQ