ID   FLAD_VIBC3              Reviewed;         377 AA.
AC   A5F6C5; C3M2X5; Q56609; Q9KQ61;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Flagellin D;
GN   Name=flaD; OrderedLocusNames=VC0395_A1727, VC395_2257;
OS   Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /
OS   O395).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=345073;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9440520; DOI=10.1128/jb.180.2.303-316.1998;
RA   Klose K.E., Mekalanos J.J.;
RT   "Differential regulation of multiple flagellins in Vibrio cholerae.";
RL   J. Bacteriol. 180:303-316(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RA   Heidelberg J.;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RX   PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA   Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA   Wang W., Wang J., Qian W., Li D., Wang L.;
RT   "A recalibrated molecular clock and independent origins for the cholera
RT   pandemic clones.";
RL   PLoS ONE 3:E4053-E4053(2008).
CC   -!- FUNCTION: Flagellin is the subunit protein which polymerizes to form
CC       the filaments of bacterial flagella. FlaD is not essential for
CC       flagellar synthesis and motility (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heteromer of multiple flagellin subunits including FlaA, FlaB,
CC       FlaC, FlaD and FlaE. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Bacterial flagellum
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: V.cholerae is able to differentially regulate the
CC       flagellins within the flagellum maybe to produce flagella which are
CC       particularly suited for motility within a given environment.
CC   -!- SIMILARITY: Belongs to the bacterial flagellin family. {ECO:0000305}.
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DR   EMBL; AF007122; AAC01556.1; -; Genomic_DNA.
DR   EMBL; CP000627; ABQ21906.1; -; Genomic_DNA.
DR   EMBL; CP001235; ACP10249.1; -; Genomic_DNA.
DR   RefSeq; WP_000290371.1; NZ_JAACZH010000001.1.
DR   AlphaFoldDB; A5F6C5; -.
DR   SMR; A5F6C5; -.
DR   STRING; 345073.VC395_2257; -.
DR   PRIDE; A5F6C5; -.
DR   EnsemblBacteria; ABQ21906; ABQ21906; VC0395_A1727.
DR   GeneID; 57740762; -.
DR   KEGG; vco:VC0395_A1727; -.
DR   KEGG; vcr:VC395_2257; -.
DR   PATRIC; fig|345073.21.peg.2181; -.
DR   eggNOG; COG1344; Bacteria.
DR   HOGENOM; CLU_011142_4_0_6; -.
DR   OMA; NSEWIAR; -.
DR   Proteomes; UP000000249; Chromosome 2.
DR   GO; GO:0009288; C:bacterial-type flagellum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 6.10.10.10; -; 1.
DR   InterPro; IPR001492; Flagellin.
DR   InterPro; IPR046358; Flagellin_C.
DR   InterPro; IPR042187; Flagellin_C_sub2.
DR   InterPro; IPR010810; Flagellin_hook_IN_motif.
DR   InterPro; IPR001029; Flagellin_N.
DR   PANTHER; PTHR42792; PTHR42792; 1.
DR   Pfam; PF00700; Flagellin_C; 1.
DR   Pfam; PF07196; Flagellin_IN; 1.
DR   Pfam; PF00669; Flagellin_N; 1.
DR   PRINTS; PR00207; FLAGELLIN.
PE   3: Inferred from homology;
KW   Bacterial flagellum; Coiled coil; Secreted.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..377
FT                   /note="Flagellin D"
FT                   /id="PRO_0000321849"
FT   COILED          103..129
FT                   /evidence="ECO:0000255"
FT   COILED          310..339
FT                   /evidence="ECO:0000255"
FT   CONFLICT        245
FT                   /note="I -> V (in Ref. 1; AAC01556)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        345
FT                   /note="T -> I (in Ref. 1; AAC01556)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   377 AA;  39904 MW;  80517DE77782AB5B CRC64;
     MAVNVNTNVA AMTAQRYLTG ATNAQQTSME RLSSGFKINS AKDDAAGLQI SNRLNVQSRG
     LDVAVRNAND GISIAQTAEG AMNETTNILQ RMRDLSLQSA NGSNSKSERV AIQEEITALN
     DELNRIAETT SFGGNKLLNG TFSTKSFQIG ADNGEAVMLT LKDMRSDNRM MGGTSYVAAE
     GKDKDWKVQA GANDITFTLK DIDGNDQTIT VNAKEGDDIE EVATYINGQT DMVKASVNEK
     GQLQIFAGNN KVTGDVAFSG GLAGALNMQA GTAETVDTID VTSVGGAQQS VAVIDSALKY
     VDSHRAELGA FQNRFNHAIS NLDNINENVN ASKSRIKDTD FAKETTALTK SQILSQASSS
     VLAQAKQAPN AALSLLG