ID   FLAD_VIBCH              Reviewed;         377 AA.
AC   P0C6C6; Q56609; Q9KQ61;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Flagellin D;
GN   Name=flaD; OrderedLocusNames=VC_2143;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-50.
RX   PubMed=8817490; DOI=10.1111/j.1365-2958.1995.mmi_18040671.x;
RA   Camilli A., Mekalanos J.J.;
RT   "Use of recombinase gene fusions to identify Vibrio cholerae genes induced
RT   during infection.";
RL   Mol. Microbiol. 18:671-683(1995).
RN   [3]
RP   PROTEIN SEQUENCE OF 2-32.
RC   STRAIN=El Tor Inaba V86;
RX   PubMed=9742694; DOI=10.1111/j.1574-6968.1998.tb13152.x;
RA   Das M., Chopra A.K., Wood T., Peterson J.W.;
RT   "Cloning, sequencing and expression of the flagellin core protein and other
RT   genes encoding structural proteins of the Vibrio cholerae flagellum.";
RL   FEMS Microbiol. Lett. 165:239-246(1998).
CC   -!- FUNCTION: Flagellin is the subunit protein which polymerizes to form
CC       the filaments of bacterial flagella. FlaD is not essential for
CC       flagellar synthesis and motility.
CC   -!- SUBUNIT: Heteromer of multiple flagellin subunits including FlaA, FlaB,
CC       FlaC, FlaD and FlaE.
CC   -!- SUBCELLULAR LOCATION: Secreted. Bacterial flagellum.
CC   -!- MISCELLANEOUS: V.cholerae is able to differentially regulate the
CC       flagellins within the flagellum maybe to produce flagella which are
CC       particularly suited for motility within a given environment.
CC   -!- SIMILARITY: Belongs to the bacterial flagellin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE003852; AAF95288.1; -; Genomic_DNA.
DR   EMBL; U25820; AAC43560.1; -; Genomic_DNA.
DR   PIR; B82112; B82112.
DR   PIR; S70806; S70806.
DR   RefSeq; NP_231774.1; NC_002505.1.
DR   RefSeq; WP_000290371.1; NZ_LT906614.1.
DR   AlphaFoldDB; P0C6C6; -.
DR   SMR; P0C6C6; -.
DR   STRING; 243277.VC_2143; -.
DR   PRIDE; P0C6C6; -.
DR   DNASU; 2613279; -.
DR   EnsemblBacteria; AAF95288; AAF95288; VC_2143.
DR   GeneID; 57740762; -.
DR   KEGG; vch:VC_2143; -.
DR   PATRIC; fig|243277.26.peg.2048; -.
DR   eggNOG; COG1344; Bacteria.
DR   HOGENOM; CLU_011142_4_0_6; -.
DR   OMA; NSEWIAR; -.
DR   BioCyc; VCHO:VC2143-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0009288; C:bacterial-type flagellum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 6.10.10.10; -; 1.
DR   InterPro; IPR001492; Flagellin.
DR   InterPro; IPR046358; Flagellin_C.
DR   InterPro; IPR042187; Flagellin_C_sub2.
DR   InterPro; IPR010810; Flagellin_hook_IN_motif.
DR   InterPro; IPR001029; Flagellin_N.
DR   PANTHER; PTHR42792; PTHR42792; 1.
DR   Pfam; PF00700; Flagellin_C; 1.
DR   Pfam; PF07196; Flagellin_IN; 1.
DR   Pfam; PF00669; Flagellin_N; 1.
DR   PRINTS; PR00207; FLAGELLIN.
PE   1: Evidence at protein level;
KW   Bacterial flagellum; Coiled coil; Direct protein sequencing;
KW   Reference proteome; Secreted.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:9742694"
FT   CHAIN           2..377
FT                   /note="Flagellin D"
FT                   /id="PRO_0000182651"
FT   COILED          103..129
FT                   /evidence="ECO:0000255"
FT   COILED          310..339
FT                   /evidence="ECO:0000255"
FT   CONFLICT        28
FT                   /note="S -> R (in Ref. 3; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   377 AA;  39904 MW;  80517DE77782AB5B CRC64;
     MAVNVNTNVA AMTAQRYLTG ATNAQQTSME RLSSGFKINS AKDDAAGLQI SNRLNVQSRG
     LDVAVRNAND GISIAQTAEG AMNETTNILQ RMRDLSLQSA NGSNSKSERV AIQEEITALN
     DELNRIAETT SFGGNKLLNG TFSTKSFQIG ADNGEAVMLT LKDMRSDNRM MGGTSYVAAE
     GKDKDWKVQA GANDITFTLK DIDGNDQTIT VNAKEGDDIE EVATYINGQT DMVKASVNEK
     GQLQIFAGNN KVTGDVAFSG GLAGALNMQA GTAETVDTID VTSVGGAQQS VAVIDSALKY
     VDSHRAELGA FQNRFNHAIS NLDNINENVN ASKSRIKDTD FAKETTALTK SQILSQASSS
     VLAQAKQAPN AALSLLG