ID   FLAE_VIBC3              Reviewed;         378 AA.
AC   A5F6A9; C3M2X6; Q56603; Q9KQ60;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Flagellin E;
GN   Name=flaE; OrderedLocusNames=VC0395_A1728, VC395_2258;
OS   Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /
OS   O395).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=345073;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9440520; DOI=10.1128/jb.180.2.303-316.1998;
RA   Klose K.E., Mekalanos J.J.;
RT   "Differential regulation of multiple flagellins in Vibrio cholerae.";
RL   J. Bacteriol. 180:303-316(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RA   Heidelberg J.;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RX   PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA   Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA   Wang W., Wang J., Qian W., Li D., Wang L.;
RT   "A recalibrated molecular clock and independent origins for the cholera
RT   pandemic clones.";
RL   PLoS ONE 3:E4053-E4053(2008).
CC   -!- FUNCTION: Flagellin is the subunit protein which polymerizes to form
CC       the filaments of bacterial flagella. FlaE is not essential for
CC       flagellar synthesis and motility.
CC   -!- SUBUNIT: Heteromer of multiple flagellin subunits including FlaA, FlaB,
CC       FlaC, FlaD and FlaE.
CC   -!- SUBCELLULAR LOCATION: Secreted. Bacterial flagellum.
CC   -!- MISCELLANEOUS: V.cholerae is able to differentially regulate the
CC       flagellins within the flagellum maybe to produce flagella which are
CC       particularly suited for motility within a given environment.
CC   -!- SIMILARITY: Belongs to the bacterial flagellin family. {ECO:0000305}.
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DR   EMBL; AF007122; AAC01555.1; -; Genomic_DNA.
DR   EMBL; CP000627; ABQ21740.1; -; Genomic_DNA.
DR   EMBL; CP001235; ACP10250.1; -; Genomic_DNA.
DR   RefSeq; WP_001251948.1; NZ_JAACZH010000001.1.
DR   AlphaFoldDB; A5F6A9; -.
DR   SMR; A5F6A9; -.
DR   STRING; 345073.VC395_2258; -.
DR   EnsemblBacteria; ABQ21740; ABQ21740; VC0395_A1728.
DR   GeneID; 57740763; -.
DR   KEGG; vco:VC0395_A1728; -.
DR   KEGG; vcr:VC395_2258; -.
DR   PATRIC; fig|345073.21.peg.2182; -.
DR   eggNOG; COG1344; Bacteria.
DR   HOGENOM; CLU_011142_7_2_6; -.
DR   OMA; FEHTINN; -.
DR   Proteomes; UP000000249; Chromosome 2.
DR   GO; GO:0009288; C:bacterial-type flagellum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 6.10.10.10; -; 1.
DR   InterPro; IPR001492; Flagellin.
DR   InterPro; IPR046358; Flagellin_C.
DR   InterPro; IPR042187; Flagellin_C_sub2.
DR   InterPro; IPR010810; Flagellin_hook_IN_motif.
DR   InterPro; IPR001029; Flagellin_N.
DR   PANTHER; PTHR42792; PTHR42792; 1.
DR   Pfam; PF00700; Flagellin_C; 1.
DR   Pfam; PF07196; Flagellin_IN; 1.
DR   Pfam; PF00669; Flagellin_N; 1.
DR   PRINTS; PR00207; FLAGELLIN.
PE   3: Inferred from homology;
KW   Bacterial flagellum; Coiled coil; Secreted.
FT   CHAIN           1..378
FT                   /note="Flagellin E"
FT                   /id="PRO_0000321850"
FT   COILED          98..139
FT                   /evidence="ECO:0000255"
FT   COILED          311..339
FT                   /evidence="ECO:0000255"
FT   CONFLICT        296
FT                   /note="T -> A (in Ref. 1; AAC01555)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   378 AA;  41042 MW;  BD1D07BE28C46CFF CRC64;
     MAMTVNTNVS ALVAQRHLNS ASEMLNQSLE RLSSGNRINS AKDDAAGLQI SNRLETQMRG
     LGIAVRNAND GISIMQTAEG AMQETTQLLQ RMRDLSLQSA NGSNSAAERV ALQEEMAALN
     DELNRIAETT SFAGRKLLNG QFMKASFQIG ASSGEAVQLS LRNMRSDSLE MGGFSYVAAA
     LADKQWQVTK GKQQLNISYV NAQGENENIQ IQAKEGDDIE ELATYINGKT DKVSASVNEK
     GQLQLYIAGK ETSGTLSFSG SLANELQMNL LGYEAVDNLD ISSAGGAQRA VSVIDTALKY
     VDGHRSELGA MQNRFQHAIS NLDNVHENLA ASNSRIKDAD YAKETTQMIK QQILQQVSTS
     VLAQAKRQPK FVLFLLRN