FLAE_VIBCH
ID FLAE_VIBCH Reviewed; 378 AA.
AC P0C6C7; Q56603; Q9KQ60;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Flagellin E;
GN Name=flaE; OrderedLocusNames=VC_2144;
OS Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=243277;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX PubMed=10952301; DOI=10.1038/35020000;
RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT cholerae.";
RL Nature 406:477-483(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 344-378.
RX PubMed=8817490; DOI=10.1111/j.1365-2958.1995.mmi_18040671.x;
RA Camilli A., Mekalanos J.J.;
RT "Use of recombinase gene fusions to identify Vibrio cholerae genes induced
RT during infection.";
RL Mol. Microbiol. 18:671-683(1995).
CC -!- FUNCTION: Flagellin is the subunit protein which polymerizes to form
CC the filaments of bacterial flagella. FlaE is not essential for
CC flagellar synthesis and motility.
CC -!- SUBUNIT: Heteromer of multiple flagellin subunits including FlaA, FlaB,
CC FlaC, FlaD and FlaE.
CC -!- SUBCELLULAR LOCATION: Secreted. Bacterial flagellum.
CC -!- MISCELLANEOUS: V.cholerae is able to differentially regulate the
CC flagellins within the flagellum maybe to produce flagella which are
CC particularly suited for motility within a given environment.
CC -!- SIMILARITY: Belongs to the bacterial flagellin family. {ECO:0000305}.
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DR EMBL; AE003852; AAF95289.1; -; Genomic_DNA.
DR EMBL; U25727; AAC43555.1; -; Genomic_DNA.
DR PIR; C82112; C82112.
DR PIR; S70805; S70805.
DR RefSeq; NP_231775.1; NC_002505.1.
DR RefSeq; WP_001251948.1; NZ_LT906614.1.
DR AlphaFoldDB; P0C6C7; -.
DR SMR; P0C6C7; -.
DR STRING; 243277.VC_2144; -.
DR PRIDE; P0C6C7; -.
DR DNASU; 2613280; -.
DR EnsemblBacteria; AAF95289; AAF95289; VC_2144.
DR GeneID; 57740763; -.
DR KEGG; vch:VC_2144; -.
DR PATRIC; fig|243277.26.peg.2049; -.
DR eggNOG; COG1344; Bacteria.
DR HOGENOM; CLU_011142_7_2_6; -.
DR OMA; FEHTINN; -.
DR BioCyc; VCHO:VC2144-MON; -.
DR Proteomes; UP000000584; Chromosome 1.
DR GO; GO:0009288; C:bacterial-type flagellum; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 6.10.10.10; -; 1.
DR InterPro; IPR001492; Flagellin.
DR InterPro; IPR046358; Flagellin_C.
DR InterPro; IPR042187; Flagellin_C_sub2.
DR InterPro; IPR010810; Flagellin_hook_IN_motif.
DR InterPro; IPR001029; Flagellin_N.
DR PANTHER; PTHR42792; PTHR42792; 1.
DR Pfam; PF00700; Flagellin_C; 1.
DR Pfam; PF07196; Flagellin_IN; 1.
DR Pfam; PF00669; Flagellin_N; 1.
DR PRINTS; PR00207; FLAGELLIN.
PE 3: Inferred from homology;
KW Bacterial flagellum; Coiled coil; Reference proteome; Secreted.
FT CHAIN 1..378
FT /note="Flagellin E"
FT /id="PRO_0000182652"
FT COILED 98..139
FT /evidence="ECO:0000255"
FT COILED 311..339
FT /evidence="ECO:0000255"
SQ SEQUENCE 378 AA; 41042 MW; BD1D07BE28C46CFF CRC64;
MAMTVNTNVS ALVAQRHLNS ASEMLNQSLE RLSSGNRINS AKDDAAGLQI SNRLETQMRG
LGIAVRNAND GISIMQTAEG AMQETTQLLQ RMRDLSLQSA NGSNSAAERV ALQEEMAALN
DELNRIAETT SFAGRKLLNG QFMKASFQIG ASSGEAVQLS LRNMRSDSLE MGGFSYVAAA
LADKQWQVTK GKQQLNISYV NAQGENENIQ IQAKEGDDIE ELATYINGKT DKVSASVNEK
GQLQLYIAGK ETSGTLSFSG SLANELQMNL LGYEAVDNLD ISSAGGAQRA VSVIDTALKY
VDGHRSELGA MQNRFQHAIS NLDNVHENLA ASNSRIKDAD YAKETTQMIK QQILQQVSTS
VLAQAKRQPK FVLFLLRN