FLAV_NOSS1
ID FLAV_NOSS1 Reviewed; 170 AA.
AC P0A3D9; P11241;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Flavodoxin;
GN Name=isiB; OrderedLocusNames=alr2405;
OS Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576).
OC Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX NCBI_TaxID=103690;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2500643; DOI=10.1093/nar/17.11.4384;
RA Leonhardt K.G., Straus N.A.;
RT "Sequence of the flavodoxin gene from Anabaena variabilis 7120.";
RL Nucleic Acids Res. 17:4384-4384(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A.,
RA Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M.,
RA Takazawa M., Yamada M., Yasuda M., Tabata S.;
RT "Complete genomic sequence of the filamentous nitrogen-fixing
RT cyanobacterium Anabaena sp. strain PCC 7120.";
RL DNA Res. 8:205-213(2001).
RN [3]
RP STRUCTURE BY NMR.
RX PubMed=2125478; DOI=10.1021/bi00493a014;
RA Stockman B.J., Krezel A.M., Markley J.L., Leonhardt K.G., Straus N.A.;
RT "Hydrogen-1, carbon-13, and nitrogen-15 NMR spectroscopy of Anabaena 7120
RT flavodoxin: assignment of beta-sheet and flavin binding site resonances and
RT analysis of protein-flavin interactions.";
RL Biochemistry 29:9600-9609(1990).
RN [4]
RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
RX PubMed=1303762; DOI=10.1002/pro.5560011103;
RA Rao S.T., Shaffie F., Yu C., Satyshur K.A., Stockman B.J., Markley J.L.,
RA Sundaralingam M.;
RT "Structure of the oxidized long-chain flavodoxin from Anabaena 7120 at 2-A
RT resolution.";
RL Protein Sci. 1:1413-1427(1992).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS).
RX PubMed=15299298; DOI=10.1107/s0907444994011716;
RA Burkhart B.M., Ramakrishnan B., Yan H., Reedstrom R.J., Markley J.L.,
RA Straus N.A., Sundaralingam M.;
RT "Structure of the trigonal form of recombinant oxidized flavodoxin from
RT Anabaena 7120 at 1.40-A resolution.";
RL Acta Crystallogr. D 51:318-330(1995).
CC -!- FUNCTION: Low-potential electron donor to a number of redox enzymes.
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC -!- SIMILARITY: Belongs to the flavodoxin family. {ECO:0000305}.
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DR EMBL; X14577; CAA32720.1; -; Genomic_DNA.
DR EMBL; BA000019; BAB74104.1; -; Genomic_DNA.
DR PIR; AF2106; AF2106.
DR RefSeq; WP_010996561.1; NZ_RSCN01000002.1.
DR PDB; 1FLV; X-ray; 2.00 A; A=2-170.
DR PDB; 1RCF; X-ray; 1.40 A; A=2-170.
DR PDBsum; 1FLV; -.
DR PDBsum; 1RCF; -.
DR AlphaFoldDB; P0A3D9; -.
DR BMRB; P0A3D9; -.
DR SMR; P0A3D9; -.
DR STRING; 103690.17131497; -.
DR DrugBank; DB03247; Flavin mononucleotide.
DR EnsemblBacteria; BAB74104; BAB74104; BAB74104.
DR KEGG; ana:alr2405; -.
DR eggNOG; COG0716; Bacteria.
DR OMA; ICGIPTW; -.
DR OrthoDB; 1961680at2; -.
DR EvolutionaryTrace; P0A3D9; -.
DR Proteomes; UP000002483; Chromosome.
DR GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR Gene3D; 3.40.50.360; -; 1.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR001226; Flavodoxin_CS.
DR InterPro; IPR010086; Flavodoxin_lc.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR PIRSF; PIRSF038996; FldA; 1.
DR SUPFAM; SSF52218; SSF52218; 1.
DR TIGRFAMs; TIGR01752; flav_long; 1.
DR PROSITE; PS00201; FLAVODOXIN; 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Flavoprotein; FMN; Reference proteome;
KW Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..170
FT /note="Flavodoxin"
FT /id="PRO_0000171601"
FT DOMAIN 5..165
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00088"
FT STRAND 5..9
FT /evidence="ECO:0007829|PDB:1RCF"
FT STRAND 12..14
FT /evidence="ECO:0007829|PDB:1RCF"
FT HELIX 15..26
FT /evidence="ECO:0007829|PDB:1RCF"
FT TURN 27..29
FT /evidence="ECO:0007829|PDB:1RCF"
FT STRAND 32..36
FT /evidence="ECO:0007829|PDB:1RCF"
FT HELIX 42..47
FT /evidence="ECO:0007829|PDB:1RCF"
FT STRAND 49..54
FT /evidence="ECO:0007829|PDB:1RCF"
FT TURN 59..61
FT /evidence="ECO:0007829|PDB:1RCF"
FT HELIX 65..71
FT /evidence="ECO:0007829|PDB:1RCF"
FT HELIX 72..76
FT /evidence="ECO:0007829|PDB:1RCF"
FT STRAND 83..89
FT /evidence="ECO:0007829|PDB:1RCF"
FT TURN 92..97
FT /evidence="ECO:0007829|PDB:1RCF"
FT HELIX 101..112
FT /evidence="ECO:0007829|PDB:1RCF"
FT STRAND 138..144
FT /evidence="ECO:0007829|PDB:1RCF"
FT TURN 146..148
FT /evidence="ECO:0007829|PDB:1RCF"
FT HELIX 150..152
FT /evidence="ECO:0007829|PDB:1RCF"
FT HELIX 153..167
FT /evidence="ECO:0007829|PDB:1RCF"
SQ SEQUENCE 170 AA; 18964 MW; 069E8DEBA9E33302 CRC64;
MSKKIGLFYG TQTGKTESVA EIIRDEFGND VVTLHDVSQA EVTDLNDYQY LIIGCPTWNI
GELQSDWEGL YSELDDVDFN GKLVAYFGTG DQIGYADNFQ DAIGILEEKI SQRGGKTVGY
WSTDGYDFND SKALRNGKFV GLALDEDNQS DLTDDRIKSW VAQLKSEFGL
