FLAV_SYNE7
ID FLAV_SYNE7 Reviewed; 170 AA.
AC P10340; Q31MZ8;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Flavodoxin;
GN Name=isiB; OrderedLocusNames=Synpcc7942_1541;
OS Synechococcus elongatus (strain PCC 7942 / FACHB-805) (Anacystis nidulans
OS R2).
OC Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus.
OX NCBI_TaxID=1140;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3121586; DOI=10.1128/jb.170.1.258-265.1988;
RA Laudenbach D.E., Reith M.E., Straus N.A.;
RT "Isolation, sequence analysis, and transcriptional studies of the
RT flavodoxin gene from Anacystis nidulans R2.";
RL J. Bacteriol. 170:258-265(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7942 / FACHB-805;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M.,
RA Kyrpides N., Lykidis A., Richardson P.;
RT "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP PROTEIN SEQUENCE OF 2-56, AND X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
RX PubMed=6406674; DOI=10.1016/s0022-2836(83)80277-0;
RA Smith W.W., Pattridge K.A., Ludwig M.L., Petsko G.A., Tsernoglou D.,
RA Tanaka M., Yasunobu K.T.;
RT "Structure of oxidized flavodoxin from Anacystis nidulans.";
RL J. Mol. Biol. 165:737-753(1983).
RN [4]
RP X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).
RX PubMed=10610791; DOI=10.1006/jmbi.1999.3151;
RA Drennan C.L., Pattridge K.A., Weber C.H., Metzger A.L., Hoover D.M.,
RA Ludwig M.L.;
RT "Refined structures of oxidized flavodoxin from Anacystis nidulans.";
RL J. Mol. Biol. 294:711-724(1999).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (1.86 ANGSTROMS).
RX PubMed=10610792; DOI=10.1006/jmbi.1999.3152;
RA Hoover D.M., Drennan C.L., Metzger A.L., Osborne C., Weber C.H.,
RA Pattridge K.A., Ludwig M.L.;
RT "Comparisons of wild-type and mutant flavodoxins from Anacystis nidulans.
RT Structural determinants of the redox potentials.";
RL J. Mol. Biol. 294:725-743(1999).
RN [6]
RP STRUCTURE BY NMR.
RX PubMed=1907844; DOI=10.1021/bi00245a008;
RA Clubb R.T., Thanabal V., Osborne C., Wagner G.;
RT "1H and 15N resonance assignments of oxidized flavodoxin from Anacystis
RT nidulans with 3D NMR.";
RL Biochemistry 30:7718-7730(1991).
CC -!- FUNCTION: Low-potential electron donor to a number of redox enzymes.
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC -!- INDUCTION: By iron stress.
CC -!- SIMILARITY: Belongs to the flavodoxin family. {ECO:0000305}.
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DR EMBL; M19116; AAA22050.1; -; Genomic_DNA.
DR EMBL; CP000100; ABB57571.1; -; Genomic_DNA.
DR RefSeq; WP_011242314.1; NC_007604.1.
DR PDB; 1CZH; X-ray; 1.86 A; A=2-170.
DR PDB; 1CZK; X-ray; 1.90 A; A=2-170.
DR PDB; 1CZL; X-ray; 1.80 A; A=2-170.
DR PDB; 1CZN; X-ray; 1.70 A; A=2-170.
DR PDB; 1CZO; X-ray; 1.85 A; A=2-170.
DR PDB; 1CZR; X-ray; 1.90 A; A=2-170.
DR PDB; 1CZU; X-ray; 2.00 A; A=2-170.
DR PDB; 1D03; X-ray; 1.85 A; A=2-170.
DR PDB; 1D04; X-ray; 1.85 A; A=2-170.
DR PDB; 1OFV; X-ray; 1.70 A; A=2-170.
DR PDB; 6KIF; EM; 3.30 A; P/X/p=2-170.
DR PDBsum; 1CZH; -.
DR PDBsum; 1CZK; -.
DR PDBsum; 1CZL; -.
DR PDBsum; 1CZN; -.
DR PDBsum; 1CZO; -.
DR PDBsum; 1CZR; -.
DR PDBsum; 1CZU; -.
DR PDBsum; 1D03; -.
DR PDBsum; 1D04; -.
DR PDBsum; 1OFV; -.
DR PDBsum; 6KIF; -.
DR AlphaFoldDB; P10340; -.
DR BMRB; P10340; -.
DR SMR; P10340; -.
DR STRING; 1140.Synpcc7942_1541; -.
DR DrugBank; DB03247; Flavin mononucleotide.
DR PRIDE; P10340; -.
DR EnsemblBacteria; ABB57571; ABB57571; Synpcc7942_1541.
DR KEGG; syf:Synpcc7942_1541; -.
DR eggNOG; COG0716; Bacteria.
DR HOGENOM; CLU_051402_1_0_3; -.
DR OMA; ICGIPTW; -.
DR OrthoDB; 1961680at2; -.
DR BioCyc; SYNEL:SYNPCC7942_1541-MON; -.
DR EvolutionaryTrace; P10340; -.
DR GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR Gene3D; 3.40.50.360; -; 1.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR001226; Flavodoxin_CS.
DR InterPro; IPR010086; Flavodoxin_lc.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR PIRSF; PIRSF038996; FldA; 1.
DR SUPFAM; SSF52218; SSF52218; 1.
DR TIGRFAMs; TIGR01752; flav_long; 1.
DR PROSITE; PS00201; FLAVODOXIN; 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Electron transport; Flavoprotein;
KW FMN; Stress response; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:6406674"
FT CHAIN 2..170
FT /note="Flavodoxin"
FT /id="PRO_0000171644"
FT DOMAIN 4..165
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00088"
FT CONFLICT 55
FT /note="C -> S (in Ref. 3; AA sequence)"
FT /evidence="ECO:0000305"
FT STRAND 4..8
FT /evidence="ECO:0007829|PDB:1CZN"
FT STRAND 11..13
FT /evidence="ECO:0007829|PDB:1CZN"
FT HELIX 14..26
FT /evidence="ECO:0007829|PDB:1CZN"
FT TURN 29..31
FT /evidence="ECO:0007829|PDB:1CZN"
FT STRAND 32..36
FT /evidence="ECO:0007829|PDB:1CZN"
FT HELIX 37..39
FT /evidence="ECO:0007829|PDB:1CZN"
FT HELIX 42..47
FT /evidence="ECO:0007829|PDB:1CZN"
FT STRAND 49..54
FT /evidence="ECO:0007829|PDB:1CZN"
FT TURN 59..61
FT /evidence="ECO:0007829|PDB:1CZN"
FT HELIX 65..70
FT /evidence="ECO:0007829|PDB:1CZN"
FT HELIX 71..76
FT /evidence="ECO:0007829|PDB:1CZN"
FT STRAND 83..89
FT /evidence="ECO:0007829|PDB:1CZN"
FT TURN 92..97
FT /evidence="ECO:0007829|PDB:1CZN"
FT HELIX 101..112
FT /evidence="ECO:0007829|PDB:1CZN"
FT STRAND 121..123
FT /evidence="ECO:0007829|PDB:1CZL"
FT STRAND 138..144
FT /evidence="ECO:0007829|PDB:1CZN"
FT TURN 146..148
FT /evidence="ECO:0007829|PDB:1CZN"
FT HELIX 150..152
FT /evidence="ECO:0007829|PDB:1CZN"
FT HELIX 153..167
FT /evidence="ECO:0007829|PDB:1CZN"
SQ SEQUENCE 170 AA; 18778 MW; 7291AEF23DCA0345 CRC64;
MAKIGLFYGT QTGVTQTIAE SIQQEFGGES IVDLNDIANA DASDLNAYDY LIIGCPTWNV
GELQSDWEGI YDDLDSVNFQ GKKVAYFGAG DQVGYSDNFQ DAMGILEEKI SSLGSQTVGY
WPIEGYDFNE SKAVRNNQFV GLAIDEDNQP DLTKNRIKTW VSQLKSEFGL
