FLBA_EMENI
ID FLBA_EMENI Reviewed; 719 AA.
AC P38093; C8UZV8; Q5B0N7;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 25-MAY-2022, entry version 127.
DE RecName: Full=Developmental regulator flbA;
GN Name=flbA; ORFNames=AN5893;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7830576; DOI=10.1111/j.1365-2958.1994.tb01293.x;
RA Lee B.N., Adams T.H.;
RT "Overexpression of flbA, an early regulator of Aspergillus asexual
RT sporulation, leads to activation of brlA and premature initiation of
RT development.";
RL Mol. Microbiol. 14:323-334(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- FUNCTION: Required for asexual sporulation and normal colony
CC development. May be involved in brlA activation. Could play a
CC regulatory role in controlling the flug-initiated signal transduction
CC pathway that triggers the asexual reproduction.
CC -!- DEVELOPMENTAL STAGE: Present throughout the asexual cycle.
CC -!- DOMAIN: The fungal-differentiation regulator (Fungal-DR) domain is only
CC found in fungal regulator of G-protein signaling (RGS) proteins that
CC regulate differentiation pathways. It is required for function (By
CC similarity). {ECO:0000250}.
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DR EMBL; L24395; AAA73955.1; -; mRNA.
DR EMBL; AACD01000100; EAA58402.1; -; Genomic_DNA.
DR EMBL; BN001301; CBF70620.1; -; Genomic_DNA.
DR PIR; S60771; S60771.
DR RefSeq; XP_663497.1; XM_658405.1.
DR AlphaFoldDB; P38093; -.
DR STRING; 162425.CADANIAP00007140; -.
DR PRIDE; P38093; -.
DR EnsemblFungi; CBF70620; CBF70620; ANIA_05893.
DR EnsemblFungi; EAA58402; EAA58402; AN5893.2.
DR GeneID; 2870704; -.
DR KEGG; ani:AN5893.2; -.
DR VEuPathDB; FungiDB:AN5893; -.
DR eggNOG; KOG3589; Eukaryota.
DR HOGENOM; CLU_013365_0_1_1; -.
DR InParanoid; P38093; -.
DR OMA; WLMDCTD; -.
DR OrthoDB; 582482at2759; -.
DR Proteomes; UP000000560; Chromosome I.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0030436; P:asexual sporulation; IMP:AspGD.
DR GO; GO:0048315; P:conidium formation; IMP:AspGD.
DR GO; GO:0035556; P:intracellular signal transduction; IMP:AspGD.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0010914; P:positive regulation of sterigmatocystin biosynthetic process; IMP:AspGD.
DR GO; GO:0075306; P:regulation of conidium formation; IMP:AspGD.
DR GO; GO:1900376; P:regulation of secondary metabolite biosynthetic process; IMP:AspGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:AspGD.
DR GO; GO:0045461; P:sterigmatocystin biosynthetic process; IMP:AspGD.
DR GO; GO:0045574; P:sterigmatocystin catabolic process; IMP:AspGD.
DR Gene3D; 1.10.10.10; -; 2.
DR Gene3D; 1.10.167.10; -; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00049; DEP; 2.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF46785; SSF46785; 2.
DR SUPFAM; SSF48097; SSF48097; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50132; RGS; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Signal transduction inhibitor.
FT CHAIN 1..719
FT /note="Developmental regulator flbA"
FT /id="PRO_0000204172"
FT DOMAIN 425..511
FT /note="DEP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT DOMAIN 540..685
FT /note="RGS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..411
FT /note="Fungal-DR"
FT REGION 694..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..719
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 719 AA; 78799 MW; 7AB5D3ABC0E53AC8 CRC64;
MPTSISTAPL SQGSPPSSLI DYQPQSVPSS SSPPPSTAAA AAAAVVVAVP SSSSPVDLGL
PSFTSTSSLI TSDVPATTTT PSFTGSVIGS ISRRNRRSFA ALAREKTSSA LANLSSIGST
TNSSLRQSAS SGSLQKHSRK ASQLSVGEIS GFVPLSPPLS DGSGSSEQSS SAPFEPLSAV
TEQPNPAAER RRQTIQLVPP ISENIPVSPA KMHQTSSRLL RMTEDDRPFT KDFMDLFSTL
MVSLKLDSHR VRFTKYDHTF TSEEAINNLG SLKFSQSNRM PDPKDPSRIV TTTTTTTFSM
AKEMARSVCQ RFVDARFIES VDGKYSHTFP LKGALYQLTP KGINILQRFC QRNGITARHV
IDVLESPRNT MQLVNLERDT ETDKLSHDRA TIEVIFRRFA GQDGPNVKSS VSSSDSDSLS
DYSNGLVGVK MARERKVGDK ICANTFTGKA AVDWLMDCST TIEPRETVLI AELFVKYGLI
TVLQEDRSMP QVENSLVAFQ PSKNAIYAIT ERGQRVCGWL ARDKPRDTTT YDSRGIPRDS
NNARLNHILQ DPALRLLFRE FLRFSLCEEN LSFYIDVSEF TTQYHKFDKV GHFKKPDAVR
ETLAAAYGLY NAFLAPGSPC ELNIDHALRN SLASRMTKAV GDDDSMLKSL QEVVQLFEMA
QTSVFKLMSS DSVPKFLRDP KYSAILQEHD VDDLIGGGRS YSPTPGNVPE RSMSRSQRS
