FLBD_CAUVC
ID FLBD_CAUVC Reviewed; 455 AA.
AC P17899;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 2.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Transcriptional regulatory protein FlbD;
GN Name=flbD; Synonyms=ftrC; OrderedLocusNames=CC_0909;
OS Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=190650;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 19089 / CB15;
RX PubMed=2315326; DOI=10.1073/pnas.87.6.2369;
RA Ramakrishnan G., Newton A.;
RT "FlbD of Caulobacter crescentus is a homologue of the NtrC (NRI) protein
RT and activates sigma 54-dependent flagellar gene promoters.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:2369-2373(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA van Way S.M., Mullin D.A.;
RL Submitted (JUN-1990) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19089 / CB15;
RX PubMed=11259647; DOI=10.1073/pnas.061029298;
RA Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT "Complete genome sequence of Caulobacter crescentus.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC -!- FUNCTION: Activation of sigma-54-dependent flagellar gene promoters and
CC strong negative autoregulatory effects on its own promoter. The
CC synthesis and function of FlbD in C.crescentus is controlled by an
CC internal cell-cycle clock.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- MISCELLANEOUS: FldB is transcribed during a very brief time in the cell
CC cycle just before the periodic expression of FlbG and its other target
CC genes.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M32065; AAA23037.1; -; Genomic_DNA.
DR EMBL; M69228; AAA23039.1; -; Genomic_DNA.
DR EMBL; M30946; AAA23043.1; -; Genomic_DNA.
DR EMBL; AE005673; AAK22893.1; -; Genomic_DNA.
DR PIR; A35097; A35097.
DR RefSeq; NP_419725.1; NC_002696.2.
DR RefSeq; WP_010918793.1; NC_002696.2.
DR AlphaFoldDB; P17899; -.
DR SMR; P17899; -.
DR STRING; 190650.CC_0909; -.
DR EnsemblBacteria; AAK22893; AAK22893; CC_0909.
DR KEGG; ccr:CC_0909; -.
DR PATRIC; fig|190650.5.peg.922; -.
DR eggNOG; COG2204; Bacteria.
DR HOGENOM; CLU_000445_0_2_5; -.
DR OMA; ARYIHQQ; -.
DR BioCyc; CAULO:CC0909-MON; -.
DR Proteomes; UP000001816; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR002197; HTH_Fis.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR002078; Sigma_54_int.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR025943; Sigma_54_int_dom_ATP-bd_2.
DR InterPro; IPR025944; Sigma_54_int_dom_CS.
DR InterPro; IPR029995; TR_FlbD/FleR/FlgR.
DR PANTHER; PTHR32071:SF21; PTHR32071:SF21; 1.
DR Pfam; PF02954; HTH_8; 1.
DR Pfam; PF00158; Sigma54_activat; 1.
DR PRINTS; PR01590; HTHFIS.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR PROSITE; PS00676; SIGMA54_INTERACT_2; 1.
DR PROSITE; PS00688; SIGMA54_INTERACT_3; 1.
DR PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE 4: Predicted;
KW Activator; ATP-binding; Bacterial flagellum biogenesis; Cytoplasm;
KW DNA-binding; Nucleotide-binding; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Two-component regulatory system.
FT CHAIN 1..455
FT /note="Transcriptional regulatory protein FlbD"
FT /id="PRO_0000081103"
FT DOMAIN 2..114
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DOMAIN 120..349
FT /note="Sigma-54 factor interaction"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT DNA_BIND 416..435
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT BINDING 148..155
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT BINDING 211..220
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
SQ SEQUENCE 455 AA; 48764 MW; 24E2858EB6FA2924 CRC64;
MRLLVVGKLN GQLSVAVKMA MNAGAKVSHV ETTEQATNAL RAGQGADLLM VDYVLDIAGL
IAANEAERMR VPVVACGVDA DPMRAANAIK AGAKEFIPLP PDAELIAAVL AAVTDDEKPM
VVRDPAMEQV IKLADQVAPS EASILITGES GSGKEVMARY VHGKSRRAKA PFISVNCAAI
PENLLESELF GHEKGAFTGA MARRIGKFEE ADGGTLLLDE ISEMDVRLQA KLLRAIQERE
IDRVGGSKPV KVNIRILATS NRDLAQAVKD GTFREDLLYR LNVVNLRLPP LRERPADVIS
LCEFFVKKYS AANGIEEKPI SAEAKRRLIA HRWPGNVREL ENAMHRAVLL SAGPEIEEFA
IRLPDGQPMA PAPDVAVARG AQMAADAASR AFVGSTVAEV EQQLIIDTLE HCLGNRTHAA
NILGISIRTL RNKLKEYSDA GVQVPPPQGG VGAAA
