ID   AKR_CHICK               Reviewed;         269 AA.
AC   Q90655;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Homeobox protein AKR;
DE   AltName: Full=Avian knotted-related protein;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=7667102; DOI=10.1093/nar/23.16.3252;
RA   Ryan A.K., Tejada M.L., May D.L., Dubaova M., Deeley R.G.;
RT   "Isolation and characterization of the chicken homeodomain protein AKR.";
RL   Nucleic Acids Res. 23:3252-3259(1995).
CC   -!- FUNCTION: Binds to the F' element of the APOVLDLII gene and represses
CC       its transcription.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the TALE/TGIF homeobox family. {ECO:0000305}.
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DR   EMBL; U25353; AAA83567.1; -; mRNA.
DR   PIR; S58439; S58439.
DR   RefSeq; NP_990710.1; NM_205379.1.
DR   AlphaFoldDB; Q90655; -.
DR   SMR; Q90655; -.
DR   STRING; 9031.ENSGALP00000023838; -.
DR   PaxDb; Q90655; -.
DR   Ensembl; ENSGALT00000023884; ENSGALP00000023838; ENSGALG00000014795.
DR   GeneID; 396339; -.
DR   KEGG; gga:396339; -.
DR   CTD; 7050; -.
DR   VEuPathDB; HostDB:geneid_396339; -.
DR   eggNOG; KOG0773; Eukaryota.
DR   GeneTree; ENSGT00940000155230; -.
DR   HOGENOM; CLU_034318_2_0_1; -.
DR   InParanoid; Q90655; -.
DR   PhylomeDB; Q90655; -.
DR   TreeFam; TF318093; -.
DR   PRO; PR:Q90655; -.
DR   Proteomes; UP000000539; Chromosome 2.
DR   Bgee; ENSGALG00000014795; Expressed in spermatocyte and 13 other tissues.
DR   ExpressionAtlas; Q90655; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IC:Roslin.
DR   GO; GO:0003677; F:DNA binding; IDA:Roslin.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:Roslin.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..269
FT                   /note="Homeobox protein AKR"
FT                   /id="PRO_0000048810"
FT   DNA_BIND        35..97
FT                   /note="Homeobox; TALE-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          213..236
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   269 AA;  29442 MW;  1074355DCC0C2253 CRC64;
     MKSKKGVVAI SGSETEDDDT MDVPLDLSSS AGSGKRRRRG NLPKESVQIL RDWLYEHRYN
     AYPSEQEKVL LSRQTHLSTL QVCNWFINAR RRLLPDMLRK DGKDPNQFTI SRRGTKLPEG
     SMVESSMGTK NFLPLLEESP FLPASATLSK TVSSSKPVSP GSVLARPSVI CHTTVTALKD
     APFHFCQPGD VGQTTDLQQP PANAFTDSSL SYHEDASKLG PGANAQSGLF NTPPPTPPDL
     NQDFSGFQLL VDVALKRAAE MELQAKLMA