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FLGE_BRUME
ID   FLGE_BRUME              Reviewed;         396 AA.
AC   Q8YDL6;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Flagellar hook protein FlgE;
GN   Name=flgE; OrderedLocusNames=BMEII0159;
OS   Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=224914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=16M / ATCC 23456 / NCTC 10094;
RX   PubMed=11756688; DOI=10.1073/pnas.221575398;
RA   DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA   Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA   Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA   Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA   Haselkorn R., Kyrpides N.C., Overbeek R.;
RT   "The genome sequence of the facultative intracellular pathogen Brucella
RT   melitensis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
RN   [2]
RP   FUNCTION IN INFECTION PERSISTENCE, EXPRESSION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=16M / ATCC 23456 / NCTC 10094;
RX   PubMed=15839898; DOI=10.1111/j.1462-5822.2005.00502.x;
RA   Fretin D., Fauconnier A., Koehler S., Halling S., Leonard S., Nijskens C.,
RA   Ferooz J., Lestrate P., Delrue R.-M., Danese I., Vandenhaute J., Tibor A.,
RA   DeBolle X., Letesson J.-J.;
RT   "The sheathed flagellum of Brucella melitensis is involved in persistence
RT   in a murine model of infection.";
RL   Cell. Microbiol. 7:687-698(2005).
CC   -!- FUNCTION: The flagellum is required to cause a persistent disease in a
CC       murine model of infection. {ECO:0000269|PubMed:15839898}.
CC   -!- SUBCELLULAR LOCATION: Bacterial flagellum basal body {ECO:0000250}.
CC   -!- INDUCTION: Expressed at the onset of the exponential phase (after 4, 8
CC       and 12 hours of culture) but not at later time points.
CC   -!- DISRUPTION PHENOTYPE: A flgE mutant is attenuated in a murine model of
CC       infection. Four weeks after infection, the number of cfu per spleen
CC       from mice infected with the mutant is significantly lower than the
CC       number from mice infected with the wild-type.
CC       {ECO:0000269|PubMed:15839898}.
CC   -!- SIMILARITY: Belongs to the flagella basal body rod proteins family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Despite the presence of a stop codon in position 243 in the
CC       fliF gene and in position 127 in the flhA gene, it has been shown that
CC       B.melitensis is able to express genes corresponding to the M ring, the
CC       hook and the filament of the flagellar apparatus in the early log phase
CC       of growth in 2YT broth. Under these conditions, a polar and sheathed
CC       flagellar structure is visible by transmission electron microscopy.
CC       {ECO:0000305}.
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DR   EMBL; AE008918; AAL53400.1; -; Genomic_DNA.
DR   PIR; AE3529; AE3529.
DR   RefSeq; WP_004680995.1; NZ_GG703779.1.
DR   AlphaFoldDB; Q8YDL6; -.
DR   SMR; Q8YDL6; -.
DR   STRING; 224914.BMEII0159; -.
DR   EnsemblBacteria; AAL53400; AAL53400; BMEII0159.
DR   GeneID; 29595573; -.
DR   KEGG; bme:BMEII0159; -.
DR   PATRIC; fig|224914.52.peg.3230; -.
DR   eggNOG; COG1749; Bacteria.
DR   OMA; SNVDMSQ; -.
DR   PhylomeDB; Q8YDL6; -.
DR   PRO; PR:Q8YDL6; -.
DR   Proteomes; UP000000419; Chromosome II.
DR   GO; GO:0009425; C:bacterial-type flagellum basal body; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.98.20; -; 1.
DR   InterPro; IPR011491; Falgellar_hook_FlgE.
DR   InterPro; IPR037058; Falgellar_hook_FlgE_sf.
DR   InterPro; IPR001444; Flag_bb_rod_N.
DR   InterPro; IPR019776; Flagellar_basal_body_rod_CS.
DR   InterPro; IPR020013; Flagellar_FlgE/F/G.
DR   InterPro; IPR010930; Flg_bb/hook_C_dom.
DR   InterPro; IPR037925; FlgE/F/G-like.
DR   Pfam; PF07559; FlaE; 1.
DR   Pfam; PF00460; Flg_bb_rod; 1.
DR   Pfam; PF06429; Flg_bbr_C; 1.
DR   SUPFAM; SSF117143; SSF117143; 1.
DR   TIGRFAMs; TIGR03506; FlgEFG_subfam; 1.
DR   PROSITE; PS00588; FLAGELLA_BB_ROD; 1.
PE   1: Evidence at protein level;
KW   Bacterial flagellum.
FT   CHAIN           1..396
FT                   /note="Flagellar hook protein FlgE"
FT                   /id="PRO_0000180820"
SQ   SEQUENCE   396 AA;  40862 MW;  7B00A18981DBF56A CRC64;
     MSLYGMMRTG VSGMNAQANR LSTVADNIAN ASTVGYKRAE TQFSSLVLPS TAGQYNSGSV
     LTDVRYGISD QGGIRSTSST TDLAIDGNGY FVVQGPGGST YLTRAGSFVP DKNGDLVNSA
     GYYLLGAGAD EAAGGLTVAG LNIVNVNAAA LPAEGSTAGD FTVNLPSTDQ APAAGGYNHK
     TSLISYNDKG EKITLDVYFT KTGADEWNVS VKNAADGVEI GTTVLNFDPT TGDLVSGGNV
     AVNLGAYGGQ TLNLNLGGST QRAGDYTISQ AVINGQAPSS IKGVDVGNDG AVVAVYENGT
     QKVLYRIPLA NVASPDRMTV VSGNIFLPSA ESGDVRLGFP QGDGMGKIMS GTLEESNADI
     AQELTDMIEA QRSYTANSKV FQTGFELMDV LVNLKR
 
 
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