FLGE_HELPY
ID FLGE_HELPY Reviewed; 718 AA.
AC P50610;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=Flagellar hook protein FlgE;
GN Name=flgE; OrderedLocusNames=HP_0870;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-25, AND
RP CHARACTERIZATION.
RC STRAIN=CCUG 951, and DSM 4867 / CCUG 17874 / NCTC 11638;
RX PubMed=7891557; DOI=10.1111/j.1365-2958.1994.tb01307.x;
RA O'Toole P.W., Kostrzynska M., Trust T.J.;
RT "Non-motile mutants of Helicobacter pylori and Helicobacter mustelae
RT defective in flagellar hook production.";
RL Mol. Microbiol. 14:691-703(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- FUNCTION: A flexible structure which links the flagellar filament to
CC the drive apparatus in the basal body. Absence of the gene leads to
CC absence of the hook protein, lack of the flagellar filament and thus
CC loss of mobility. Approximately wild-type levels of the flagellar
CC subunits are still produced and accumulate mostly in the cytosol.
CC -!- SUBCELLULAR LOCATION: Bacterial flagellum basal body.
CC -!- MISCELLANEOUS: The N-terminal amino acid sequence was from strain CCUG
CC 951; the DNA sequence was from strain CCUG 17874. Disruption and
CC subcellular localization experiments were performed for both strains.
CC The apparent pI for the hook protein was 5.1.
CC -!- SIMILARITY: Belongs to the flagella basal body rod proteins family.
CC {ECO:0000305}.
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DR EMBL; U09549; AAA92803.1; -; Genomic_DNA.
DR EMBL; AE000511; AAD07911.1; -; Genomic_DNA.
DR PIR; F64628; F64628.
DR RefSeq; NP_207664.1; NC_000915.1.
DR RefSeq; WP_000946389.1; NC_018939.1.
DR AlphaFoldDB; P50610; -.
DR SMR; P50610; -.
DR DIP; DIP-3456N; -.
DR IntAct; P50610; 6.
DR MINT; P50610; -.
DR STRING; 85962.C694_04455; -.
DR PaxDb; P50610; -.
DR EnsemblBacteria; AAD07911; AAD07911; HP_0870.
DR KEGG; hpy:HP_0870; -.
DR PATRIC; fig|85962.47.peg.924; -.
DR eggNOG; COG1749; Bacteria.
DR OMA; TAFRYRY; -.
DR PhylomeDB; P50610; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0009425; C:bacterial-type flagellum basal body; IEA:UniProtKB-SubCell.
DR GO; GO:0044781; P:bacterial-type flagellum organization; IEA:InterPro.
DR GO; GO:0071978; P:bacterial-type flagellum-dependent swarming motility; IBA:GO_Central.
DR Gene3D; 2.60.98.20; -; 1.
DR InterPro; IPR011491; Falgellar_hook_FlgE.
DR InterPro; IPR037058; Falgellar_hook_FlgE_sf.
DR InterPro; IPR001444; Flag_bb_rod_N.
DR InterPro; IPR020013; Flagellar_FlgE/F/G.
DR InterPro; IPR010810; Flagellin_hook_IN_motif.
DR InterPro; IPR010930; Flg_bb/hook_C_dom.
DR InterPro; IPR037925; FlgE/F/G-like.
DR InterPro; IPR012835; FlgE_epsilon.
DR Pfam; PF07559; FlaE; 1.
DR Pfam; PF07196; Flagellin_IN; 1.
DR Pfam; PF00460; Flg_bb_rod; 1.
DR Pfam; PF06429; Flg_bbr_C; 1.
DR SUPFAM; SSF117143; SSF117143; 2.
DR TIGRFAMs; TIGR02489; flgE_epsilon; 1.
DR TIGRFAMs; TIGR03506; FlgEFG_subfam; 2.
PE 1: Evidence at protein level;
KW Bacterial flagellum; Direct protein sequencing; Reference proteome.
FT CHAIN 1..718
FT /note="Flagellar hook protein FlgE"
FT /id="PRO_0000180828"
FT CONFLICT 106
FT /note="S -> N (in Ref. 1; AAA92803)"
FT /evidence="ECO:0000305"
FT CONFLICT 237
FT /note="C -> Y (in Ref. 1; AAA92803)"
FT /evidence="ECO:0000305"
FT CONFLICT 259
FT /note="A -> P (in Ref. 1; AAA92803)"
FT /evidence="ECO:0000305"
FT CONFLICT 373..374
FT /note="DI -> NS (in Ref. 1; AAA92803)"
FT /evidence="ECO:0000305"
FT CONFLICT 413..414
FT /note="SV -> TI (in Ref. 1; AAA92803)"
FT /evidence="ECO:0000305"
FT CONFLICT 509
FT /note="E -> D (in Ref. 1; AAA92803)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 718 AA; 76207 MW; F36EB60684AD1333 CRC64;
MLRSLWSGVN GMQAHQIALD IESNNIANVN TTGFKYSRAS FVDMLSQVKL IATAPYKNGL
AGQNDFSVGL GVGVDATTKI FSQGNIQNTD VKTDLAIQGD GFFIISPDRG ITRNFTRDGE
FLFDSQGSLV TTGGLVVQGW VRNGSDTGNK GSDTDALKVD NTGPLENIRI DPGMVMPARA
SNRISMRANL NAGRHADQTA AIFALDSSAK TPSDGINPVY DSGTNLAQVA EDMGSLCNED
GDALLLNENQ GIWVSYKSAK MVKDILPSAE NSTLELNGVK ISFTNDSAVS RTSSLVAAKN
AINAVKSQTG IEAYLDGKQL RLENTNELDG DEKLKNIVVT QAGTGAFANF LDGDKDVTAF
KYSYTHSISP NADIGQFRTT EDLRALIQHD ANIVKDPSLA DNYQDSAASI GVSVNQYGMF
EINNKDNKNV IKENLNIFVS GYSSDSVTNN VLFKNAMKGL NTASLIEGGA SASSSKFTHA
THATSIDVID SLGTKHAMRI EFYRSGGAEW NFRVIVPEPG ELVGGSAARP NVFEGGRLHF
NNDGSLAGMN PPLLQFDPKN GADAPQRINL AFGSSGSFDG LTSVDKISET YAIEQNGYQA
GDLMDVRFDS DGVLLGAFSN GRTLALAQVA LANFANDAGL QALGGNVFSQ TGNSGQALIG
AANTGRRGSI SGSKLESSNV DLSRSLTNLI VVQRGFQANS KAVTTSDQIL NTLLNLKQ
