ID   AKTIP_CHICK             Reviewed;         293 AA.
AC   Q5ZJJ5;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=AKT-interacting protein;
DE   AltName: Full=Fused toes protein homolog;
GN   Name=AKTIP; Synonyms=FTS; ORFNames=RCJMB04_17k13;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: May function to promote vesicle trafficking and/or fusion.
CC       May also regulate apoptosis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. FTS
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00388}.
CC   -!- CAUTION: Lacks the conserved Cys residue necessary for ubiquitin-
CC       conjugating enzyme E2 activity. {ECO:0000305}.
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DR   EMBL; AJ720439; CAG32098.1; -; mRNA.
DR   RefSeq; NP_001005838.1; NM_001005838.1.
DR   RefSeq; XP_015147845.1; XM_015292359.1.
DR   AlphaFoldDB; Q5ZJJ5; -.
DR   SMR; Q5ZJJ5; -.
DR   STRING; 9031.ENSGALP00000038914; -.
DR   PaxDb; Q5ZJJ5; -.
DR   Ensembl; ENSGALT00000052968; ENSGALP00000043824; ENSGALG00000033378.
DR   Ensembl; ENSGALT00000088922; ENSGALP00000060127; ENSGALG00000033378.
DR   Ensembl; ENSGALT00000099756; ENSGALP00000068319; ENSGALG00000033378.
DR   Ensembl; ENSGALT00000107773; ENSGALP00000066755; ENSGALG00000033378.
DR   GeneID; 415720; -.
DR   KEGG; gga:415720; -.
DR   CTD; 64400; -.
DR   VEuPathDB; HostDB:geneid_415720; -.
DR   eggNOG; KOG0429; Eukaryota.
DR   GeneTree; ENSGT00390000010125; -.
DR   HOGENOM; CLU_083049_0_0_1; -.
DR   InParanoid; Q5ZJJ5; -.
DR   OMA; WGFPEWR; -.
DR   OrthoDB; 1226125at2759; -.
DR   PhylomeDB; Q5ZJJ5; -.
DR   TreeFam; TF314386; -.
DR   PRO; PR:Q5ZJJ5; -.
DR   Proteomes; UP000000539; Chromosome 11.
DR   Bgee; ENSGALG00000033378; Expressed in spermatocyte and 13 other tissues.
DR   ExpressionAtlas; Q5ZJJ5; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0070695; C:FHF complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0061631; F:ubiquitin conjugating enzyme activity; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0045022; P:early endosome to late endosome transport; ISS:UniProtKB.
DR   GO; GO:0007032; P:endosome organization; ISS:UniProtKB.
DR   GO; GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.
DR   GO; GO:0007040; P:lysosome organization; ISS:UniProtKB.
DR   GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.110.10; -; 1.
DR   InterPro; IPR000608; UBQ-conjugat_E2.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   Pfam; PF00179; UQ_con; 1.
DR   SUPFAM; SSF54495; SSF54495; 1.
DR   PROSITE; PS50127; UBC_2; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cell membrane; Cytoplasm; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..293
FT                   /note="AKT-interacting protein"
FT                   /id="PRO_0000379019"
FT   DOMAIN          74..222
FT                   /note="UBC core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00388"
FT   REGION          1..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          269..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   293 AA;  33304 MW;  1B4EC659ABCDF016 CRC64;
     MNPFWSMSAA SGRKRPEADE KTLSGELRTS PPRASAKKQL PSVPKNAVPV TKPASPAMSS
     QSTNGTHASY GPFYLEYSLL AEFTLVVKQK LPGVYVQPSY RSALMWFGVI FIRHGLYQDG
     VFKFTVYIPD NYPDGDCPRL VFDLPVFHPL VDPLSGELDV KRAFAKWRRN HNHIWQVLMY
     ARRVFYKIDT TSPLNPEAAV LYEKDIQLFK SKVVDSVKLC SSHLFDQPKI EDPYAIVFSP
     WNPAIHDEAR EKMLTQKKKP EDQHCKSMHV SGLSWVKPGS VQPFSKEEKT MPT