ID   AKTIP_DANRE             Reviewed;         293 AA.
AC   Q7ZYX1; Q6P3I9;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=AKT-interacting protein;
DE   AltName: Full=Fused toes protein homolog;
GN   Name=aktip; Synonyms=fts;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function to promote vesicle trafficking and/or fusion.
CC       May also regulate apoptosis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q7ZYX1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q7ZYX1-2; Sequence=VSP_037632, VSP_037633;
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. FTS
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00388}.
CC   -!- CAUTION: Lacks the conserved Cys residue necessary for ubiquitin-
CC       conjugating enzyme E2 activity. {ECO:0000305}.
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DR   EMBL; BC044455; AAH44455.1; -; mRNA.
DR   EMBL; BC063971; AAH63971.1; -; mRNA.
DR   RefSeq; NP_001307253.1; NM_001320324.1. [Q7ZYX1-1]
DR   RefSeq; NP_001307255.1; NM_001320326.1. [Q7ZYX1-1]
DR   RefSeq; XP_005169026.1; XM_005168969.3. [Q7ZYX1-2]
DR   AlphaFoldDB; Q7ZYX1; -.
DR   SMR; Q7ZYX1; -.
DR   STRING; 7955.ENSDARP00000122322; -.
DR   PaxDb; Q7ZYX1; -.
DR   Ensembl; ENSDART00000029565; ENSDARP00000029595; ENSDARG00000026862. [Q7ZYX1-2]
DR   Ensembl; ENSDART00000146202; ENSDARP00000122322; ENSDARG00000026862. [Q7ZYX1-1]
DR   Ensembl; ENSDART00000188703; ENSDARP00000145750; ENSDARG00000026862. [Q7ZYX1-1]
DR   Ensembl; ENSDART00000193792; ENSDARP00000153827; ENSDARG00000115058. [Q7ZYX1-1]
DR   GeneID; 378716; -.
DR   KEGG; dre:378716; -.
DR   CTD; 64400; -.
DR   ZFIN; ZDB-GENE-030909-5; aktip.
DR   eggNOG; KOG0429; Eukaryota.
DR   GeneTree; ENSGT00390000010125; -.
DR   HOGENOM; CLU_083049_0_0_1; -.
DR   InParanoid; Q7ZYX1; -.
DR   OrthoDB; 1226125at2759; -.
DR   PhylomeDB; Q7ZYX1; -.
DR   TreeFam; TF314386; -.
DR   PRO; PR:Q7ZYX1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000026862; Expressed in early embryo and 28 other tissues.
DR   ExpressionAtlas; Q7ZYX1; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0070695; C:FHF complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0061631; F:ubiquitin conjugating enzyme activity; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0045022; P:early endosome to late endosome transport; ISS:UniProtKB.
DR   GO; GO:0007032; P:endosome organization; ISS:UniProtKB.
DR   GO; GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.
DR   GO; GO:0007040; P:lysosome organization; ISS:UniProtKB.
DR   GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.110.10; -; 1.
DR   InterPro; IPR000608; UBQ-conjugat_E2.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   Pfam; PF00179; UQ_con; 1.
DR   SUPFAM; SSF54495; SSF54495; 1.
DR   PROSITE; PS50127; UBC_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Apoptosis; Cell membrane; Cytoplasm; Membrane;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..293
FT                   /note="AKT-interacting protein"
FT                   /id="PRO_0000379020"
FT   DOMAIN          75..223
FT                   /note="UBC core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00388"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          260..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        275..293
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         259..261
FT                   /note="RRP -> VSV (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_037632"
FT   VAR_SEQ         262..293
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_037633"
SQ   SEQUENCE   293 AA;  33201 MW;  7620D994B74E1340 CRC64;
     MNPFWSMSTN AGRKRSDGEE QSGSGEQRAS PARPPFGKKQ LPSIPKNAVP ITKAASPASS
     TQSANGTHAS YGPFYLEYSL LAEFTLVIKQ KLPGIYVQPS YRSALMWFGV IFIRHGLYQD
     GVFKFTVYIP DNYPDGDCPK VVFDTPVFHP LVDPVSGELD VRRAFTKWRR NHNHIWQVLM
     YARTIFYKIN TMEPLNPEAA VLYDKDIQLF KSKVVDSVKL CNSHLFDQPK IDDPYAISFS
     PWNPAVHEEA KEKMFAHKRR PEDFNKGLPV SGLSWVKPGS TQPFSKEDNP LQT