ID   AKTIP_MACFA             Reviewed;         292 AA.
AC   Q4R5E1;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=AKT-interacting protein;
DE   AltName: Full=Fused toes protein homolog;
GN   Name=AKTIP; Synonyms=FTS; ORFNames=QnpA-16528;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Parietal cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF
CC       complex may function to promote vesicle trafficking and/or fusion via
CC       the homotypic vesicular protein sorting complex (the HOPS complex).
CC       Regulates apoptosis by enhancing phosphorylation and activation of
CC       AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling
CC       cascade. FHF complex promotes the distribution of AP-4 complex to the
CC       perinuclear area of the cell. {ECO:0000250|UniProtKB:Q9H8T0}.
CC   -!- SUBUNIT: Component of the FTS/Hook/FHIP complex (FHF complex), composed
CC       of AKTIP/FTS, FHIP1B, and one or more members of the Hook family of
CC       proteins HOOK1, HOOK2, and HOOK3. Interacts directly with HOOK1, HOOK2
CC       and HOOK3. The FHF complex associates with the homotypic vesicular
CC       sorting complex (the HOPS complex). Also interacts with AKT1. May
CC       interact with FHIP1A. {ECO:0000250|UniProtKB:Q9H8T0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H8T0}. Cell
CC       membrane {ECO:0000250|UniProtKB:Q9H8T0}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q9H8T0}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. FTS
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00388}.
CC   -!- CAUTION: Lacks the conserved Cys residue necessary for ubiquitin-
CC       conjugating enzyme E2 activity. {ECO:0000305}.
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DR   EMBL; AB169603; BAE01684.1; -; mRNA.
DR   RefSeq; NP_001271900.1; NM_001284971.1.
DR   RefSeq; XP_005591984.1; XM_005591927.2.
DR   AlphaFoldDB; Q4R5E1; -.
DR   SMR; Q4R5E1; -.
DR   STRING; 9541.XP_005591978.1; -.
DR   GeneID; 101865159; -.
DR   KEGG; mcf:101865159; -.
DR   CTD; 64400; -.
DR   eggNOG; KOG0429; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0070695; C:FHF complex; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0045022; P:early endosome to late endosome transport; ISS:UniProtKB.
DR   GO; GO:0007032; P:endosome organization; ISS:UniProtKB.
DR   GO; GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.
DR   GO; GO:0007040; P:lysosome organization; ISS:UniProtKB.
DR   GO; GO:1905719; P:protein localization to perinuclear region of cytoplasm; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.110.10; -; 1.
DR   InterPro; IPR000608; UBQ-conjugat_E2.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   Pfam; PF00179; UQ_con; 1.
DR   SUPFAM; SSF54495; SSF54495; 1.
DR   PROSITE; PS50127; UBC_2; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cell membrane; Cytoplasm; Membrane; Phosphoprotein;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..292
FT                   /note="AKT-interacting protein"
FT                   /id="PRO_0000281864"
FT   DOMAIN          74..222
FT                   /note="UBC core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00388"
FT   REGION          1..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         30
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H8T0"
SQ   SEQUENCE   292 AA;  33128 MW;  3DD4E32980463324 CRC64;
     MNPFWSMSTS SVRKRSEGEE KTLTGDVKTS PPRTAPKKQL PSIPKNALPI TKPTSPAPAA
     QSTNGTHASY GPFYLEYSLL AEFTLVVKQK LPGVYVQPSY RSALMWFGVI FIRHGLYQDG
     VFKFTVYIPD NYPDGDCPRL VFDIPVFHPL VDPTSGELDV KRAFAKWRRN HNHIWQVLMY
     ARRVFYKIDT ASPLNPEAAV LYEKDIQLFK SKVVDSVKVC TARLFDQPKI EDPYAISFSP
     WNPSVHDEAR EKMLTQKKPE EQHNKSVHVA GLSWVKPGSV QPFSKEEKTV AT