ID   AKTIP_NEMVE             Reviewed;         297 AA.
AC   A7RRG3;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Protein AKTIP homolog;
DE   AltName: Full=Fused toes protein homolog;
GN   ORFNames=v1g232160;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6;
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. FTS
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00388}.
CC   -!- CAUTION: Lacks the conserved Cys residue necessary for ubiquitin-
CC       conjugating enzyme E2 activity. {ECO:0000305}.
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DR   EMBL; DS469531; EDO45944.1; -; Genomic_DNA.
DR   RefSeq; XP_001638007.1; XM_001637957.1.
DR   AlphaFoldDB; A7RRG3; -.
DR   SMR; A7RRG3; -.
DR   STRING; 45351.EDO45944; -.
DR   PRIDE; A7RRG3; -.
DR   EnsemblMetazoa; EDO45944; EDO45944; NEMVEDRAFT_v1g232160.
DR   GeneID; 5518028; -.
DR   KEGG; nve:5518028; -.
DR   eggNOG; KOG0429; Eukaryota.
DR   HOGENOM; CLU_083049_0_0_1; -.
DR   InParanoid; A7RRG3; -.
DR   OMA; WGFPEWR; -.
DR   OrthoDB; 1226125at2759; -.
DR   PhylomeDB; A7RRG3; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   Gene3D; 3.10.110.10; -; 1.
DR   InterPro; IPR000608; UBQ-conjugat_E2.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   Pfam; PF00179; UQ_con; 1.
DR   SUPFAM; SSF54495; SSF54495; 1.
DR   PROSITE; PS50127; UBC_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..297
FT                   /note="Protein AKTIP homolog"
FT                   /id="PRO_0000379025"
FT   DOMAIN          84..232
FT                   /note="UBC core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00388"
FT   REGION          13..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..75
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   297 AA;  34147 MW;  8914B4DB9FF0D90B CRC64;
     MLNVTHQLKK KLFLSDLDEK SSSSPHDEKK PGDGREVREE KSKRKALPAL PSPAEEKSMN
     LSIARQRSPS GSSPEQVKAY GPFFLEYTLM AEYNQLRSQR LPGVYVLPAA KSALVWYGVI
     FIRMGLYQDG IFKFQMTIPE NFPDGDCPTL VFKPTIFHPV VNIETGELDV RRAFPRWRRN
     INHLWQVLLY AKRIFYKIDS RDPLNPEAAE MYQNDKDRYK QKVNECLRRC HNELHLAVAD
     DPHAIKFVEL TPEKQDDVKN QIIESQSKPE CLPTANAHKS GLSWMKKGGA IFSKEES