ID   FLGM_BACSU              Reviewed;          88 AA.
AC   P39809;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Negative regulator of flagellin synthesis;
DE   AltName: Full=Anti-sigma-D factor;
GN   Name=flgM; OrderedLocusNames=BSU35430;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=8045879; DOI=10.1128/jb.176.15.4492-4500.1994;
RA   Mirel D.B., Lauer P., Chamberlin M.J.;
RT   "Identification of flagellar synthesis regulatory and structural genes in a
RT   sigma D-dependent operon of Bacillus subtilis.";
RL   J. Bacteriol. 176:4492-4500(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=8969505; DOI=10.1099/13500872-142-11-3079;
RA   Soldo B., Lazarevic V., Mauel C., Karamata D.;
RT   "Sequence of the 305 degrees-307 degrees region of the Bacillus subtilis
RT   chromosome.";
RL   Microbiology 142:3079-3088(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- FUNCTION: Allows the coupling of early and late flagellar synthesis
CC       through the repression of RNA polymerase sigma-D factor-dependent
CC       transcription.
CC   -!- SIMILARITY: Belongs to the FlgM family. {ECO:0000305}.
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DR   EMBL; L14437; AAB59017.1; -; Genomic_DNA.
DR   EMBL; U56901; AAC44944.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15560.1; -; Genomic_DNA.
DR   PIR; B69623; B69623.
DR   RefSeq; NP_391423.1; NC_000964.3.
DR   RefSeq; WP_003227997.1; NZ_JNCM01000033.1.
DR   AlphaFoldDB; P39809; -.
DR   SMR; P39809; -.
DR   STRING; 224308.BSU35430; -.
DR   jPOST; P39809; -.
DR   PaxDb; P39809; -.
DR   PRIDE; P39809; -.
DR   EnsemblBacteria; CAB15560; CAB15560; BSU_35430.
DR   GeneID; 936739; -.
DR   KEGG; bsu:BSU35430; -.
DR   PATRIC; fig|224308.179.peg.3834; -.
DR   eggNOG; COG2747; Bacteria.
DR   InParanoid; P39809; -.
DR   OMA; INQFGTQ; -.
DR   PhylomeDB; P39809; -.
DR   BioCyc; BSUB:BSU35430-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016989; F:sigma factor antagonist activity; IMP:CACAO.
DR   GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR   InterPro; IPR035890; Anti-sigma-28_factor_FlgM_sf.
DR   InterPro; IPR007412; FlgM.
DR   InterPro; IPR031316; FlgM_C.
DR   Pfam; PF04316; FlgM; 1.
DR   SUPFAM; SSF101498; SSF101498; 1.
DR   TIGRFAMs; TIGR03824; FlgM_jcvi; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum biogenesis; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..88
FT                   /note="Negative regulator of flagellin synthesis"
FT                   /id="PRO_0000087282"
SQ   SEQUENCE   88 AA;  10000 MW;  08761239DDD2D4B0 CRC64;
     MKINQFGTQS VNPYQKNYDK QAVQKTVAQP QDKIEISSQA KEMQHASDAV TGSRQEKIAQ
     LKAQIENGSY KVDANHIAKN MINFYKKQ