ID   FLGM_SHIFL              Reviewed;          97 AA.
AC   P0AEM5; P43532;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Negative regulator of flagellin synthesis;
DE   AltName: Full=Anti-sigma-28 factor;
GN   Name=flgM; OrderedLocusNames=SF1077, S1155;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Responsible for the coupling of flagellin expression to
CC       flagellar assembly by preventing expression of the flagellin genes when
CC       a component of the middle class of proteins is defective. It negatively
CC       regulates flagellar genes by inhibiting the activity of FliA by
CC       directly binding to FliA (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FlgM family. {ECO:0000305}.
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DR   EMBL; AE005674; AAN42699.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP16586.1; -; Genomic_DNA.
DR   RefSeq; NP_706992.1; NC_004337.2.
DR   RefSeq; WP_000020880.1; NZ_WPGW01000001.1.
DR   AlphaFoldDB; P0AEM5; -.
DR   SMR; P0AEM5; -.
DR   STRING; 198214.SF1077; -.
DR   EnsemblBacteria; AAN42699; AAN42699; SF1077.
DR   EnsemblBacteria; AAP16586; AAP16586; S1155.
DR   GeneID; 1024006; -.
DR   GeneID; 66670662; -.
DR   KEGG; sfl:SF1077; -.
DR   KEGG; sfx:S1155; -.
DR   PATRIC; fig|198214.7.peg.1260; -.
DR   HOGENOM; CLU_149304_2_2_6; -.
DR   OMA; QSKLMQP; -.
DR   OrthoDB; 1840161at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR035890; Anti-sigma-28_factor_FlgM_sf.
DR   InterPro; IPR007412; FlgM.
DR   InterPro; IPR031316; FlgM_C.
DR   Pfam; PF04316; FlgM; 1.
DR   SUPFAM; SSF101498; SSF101498; 1.
DR   TIGRFAMs; TIGR03824; FlgM_jcvi; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum biogenesis; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..97
FT                   /note="Negative regulator of flagellin synthesis"
FT                   /id="PRO_0000087284"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   97 AA;  10341 MW;  367D6F63324BF75D CRC64;
     MSIDRTSPLK PVSTVQPRET TDAPVTNSRA AKTTASTSTS VTLSDAQAKL MQPGSSDINL
     ERVEALKLAI RNGELKMDTG KIADALINEA QQDLQSN