AKTIP_SALSA
ID AKTIP_SALSA Reviewed; 297 AA.
AC B5X1G6;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 1.
DT 03-AUG-2022, entry version 44.
DE RecName: Full=AKT-interacting protein;
DE AltName: Full=Fused toes protein homolog;
GN Name=aktip; Synonyms=fts;
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT evolutionary pressures on a post-tetraploidization genome.";
RL BMC Genomics 11:279-279(2010).
CC -!- FUNCTION: May function to promote vesicle trafficking and/or fusion.
CC May also regulate apoptosis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. FTS
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00388}.
CC -!- CAUTION: Lacks the conserved Cys residue necessary for ubiquitin-
CC conjugating enzyme E2 activity. {ECO:0000305}.
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DR EMBL; BT044885; ACI33147.1; -; mRNA.
DR RefSeq; NP_001133394.1; NM_001139922.1.
DR AlphaFoldDB; B5X1G6; -.
DR SMR; B5X1G6; -.
DR STRING; 8030.ENSSSAP00000041470; -.
DR GeneID; 100194893; -.
DR KEGG; sasa:100194893; -.
DR CTD; 64400; -.
DR OrthoDB; 1226125at2759; -.
DR Proteomes; UP000087266; Chromosome ssa11.
DR Bgee; ENSSSAG00000044860; Expressed in ovary and 15 other tissues.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0070695; C:FHF complex; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0045022; P:early endosome to late endosome transport; ISS:UniProtKB.
DR GO; GO:0007032; P:endosome organization; ISS:UniProtKB.
DR GO; GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.
DR GO; GO:0007040; P:lysosome organization; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 3.10.110.10; -; 1.
DR InterPro; IPR000608; UBQ-conjugat_E2.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR Pfam; PF00179; UQ_con; 1.
DR SUPFAM; SSF54495; SSF54495; 1.
DR PROSITE; PS50127; UBC_2; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Cell membrane; Cytoplasm; Membrane; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..297
FT /note="AKT-interacting protein"
FT /id="PRO_0000379021"
FT DOMAIN 79..227
FT /note="UBC core"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00388"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 297 AA; 33928 MW; 16E6141D10984E29 CRC64;
MNLNPFWSMS TNTGRKRSDG EEQSGEQQQQ QRASPARPSF GKKQLPSIPK NALPITKPAS
PAATAQLANG THASYGPFYL EYSLLAEFTL VIKQKLPGIY VQPSYKSALM WFGVIFIRHG
LYQDGVFKFT VYIPDNYPDG ECPRVVFDIP VFHPLVDPVS GELDVRRAFT KWRRNHNHIW
QVLMYARTVF YKINTMEPLN PEAAVLYDKD VQLFKSKVVD SVKLCNSHLF DQPKMDDPYA
ISFSSWNPAI HDDAKERMFT HKRRPEDHHK GLQVSGLSWV KPGSTQPFSK DDNPPQN
