ID   FLH3_CAEEL              Reviewed;         420 AA.
AC   Q9XWQ6;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 2.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=FLYWCH transcription factor 3 {ECO:0000303|PubMed:18794349};
GN   Name=flh-3 {ECO:0000312|WormBase:Y11D7A.13};
GN   ORFNames=Y11D7A.13 {ECO:0000312|WormBase:Y11D7A.13};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=18794349; DOI=10.1101/gad.1678808;
RA   Ow M.C., Martinez N.J., Olsen P.H., Silverman H.S., Barrasa M.I.,
RA   Conradt B., Walhout A.J., Ambros V.;
RT   "The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic
RT   expression of microRNA genes in C. elegans.";
RL   Genes Dev. 22:2520-2534(2008).
CC   -!- FUNCTION: Probable transcription factor (PubMed:18794349). May bind to
CC       the promoters of target genes, including micro-RNA genes, in order to
CC       repress expression, and acting redundantly with flh-2
CC       (PubMed:18794349). {ECO:0000269|PubMed:18794349}.
CC   -!- DEVELOPMENTAL STAGE: Expressed during late stages of embryogenesis and
CC       larval L1 stage. {ECO:0000269|PubMed:18794349}.
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DR   EMBL; BX284604; CAA21592.2; -; Genomic_DNA.
DR   PIR; T26471; T26471.
DR   RefSeq; NP_501619.2; NM_069218.2.
DR   AlphaFoldDB; Q9XWQ6; -.
DR   IntAct; Q9XWQ6; 7.
DR   STRING; 6239.Y11D7A.13; -.
DR   EPD; Q9XWQ6; -.
DR   PaxDb; Q9XWQ6; -.
DR   PeptideAtlas; Q9XWQ6; -.
DR   EnsemblMetazoa; Y11D7A.13.1; Y11D7A.13.1; WBGene00012436.
DR   GeneID; 189435; -.
DR   KEGG; cel:CELE_Y11D7A.13; -.
DR   UCSC; Y11D7A.13; c. elegans.
DR   CTD; 189435; -.
DR   WormBase; Y11D7A.13; CE35649; WBGene00012436; flh-3.
DR   eggNOG; ENOG502TGFQ; Eukaryota.
DR   GeneTree; ENSGT00970000196226; -.
DR   HOGENOM; CLU_654235_0_0_1; -.
DR   InParanoid; Q9XWQ6; -.
DR   OMA; RCERKNT; -.
DR   OrthoDB; 1114912at2759; -.
DR   PhylomeDB; Q9XWQ6; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00012436; Expressed in embryo and 4 other tissues.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IGI:WormBase.
DR   InterPro; IPR007588; Znf_FLYWCH.
DR   Pfam; PF04500; FLYWCH; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..420
FT                   /note="FLYWCH transcription factor 3"
FT                   /id="PRO_0000453577"
FT   ZN_FING         140..195
FT                   /note="FLYWCH-type"
FT                   /evidence="ECO:0000255"
FT   REGION          87..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          119..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        121..135
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   420 AA;  48264 MW;  08EAB20C4EFECDD9 CRC64;
     MNLASQISQA KTGNATMEWA KNYVSKLNDG QLALLQKMYA DHQAKLKASE DEKKKKEMEE
     LKMKAQQQAI LDSLTQQIPI MVDVLRSSTS PDSQPSSSSS VMSSTDEDQI TVKDVLIGKI
     NKAQRQSSPN SSKPYTPRGI RERVLFDEHL YVFDKCSYDS KKRFFRCERK NTCPARIHTP
     FDAERVIHKV QVHNHPPPTT FDLAHYNIDY GKVKSGHILS LNGPQQTKNL LPPSLLTPKS
     DLEDETLSTK TEQKNASTMN ILLSMTNNCD GRKPITLRLP DLFNKISEME IHDMEMTLTK
     FLLENRELRT DLISRNGDLP VFFPNAHNDE LVLFVADQHE NDSVFQMIRV SERNEKSIRQ
     AIQEHLQKVS NRSLMMNISS KINVPLSQQM IDQWRTEEFI RLDSSKPNFW KIHHVSKLQD