ID   FLHA_AQUAE              Reviewed;         678 AA.
AC   O67265;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Flagellar biosynthesis protein FlhA;
GN   Name=flhA; OrderedLocusNames=aq_1212;
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- FUNCTION: Required for formation of the rod structure of the flagellar
CC       apparatus. Together with FliI and FliH, may constitute the export
CC       apparatus of flagellin (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC       pore) family. {ECO:0000305}.
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DR   EMBL; AE000657; AAC07227.1; -; Genomic_DNA.
DR   PIR; F70404; F70404.
DR   RefSeq; NP_213829.1; NC_000918.1.
DR   RefSeq; WP_010880767.1; NC_000918.1.
DR   AlphaFoldDB; O67265; -.
DR   SMR; O67265; -.
DR   STRING; 224324.aq_1212; -.
DR   EnsemblBacteria; AAC07227; AAC07227; aq_1212.
DR   KEGG; aae:aq_1212; -.
DR   PATRIC; fig|224324.8.peg.943; -.
DR   eggNOG; COG1298; Bacteria.
DR   HOGENOM; CLU_015346_3_0_0; -.
DR   InParanoid; O67265; -.
DR   OMA; MAINPGQ; -.
DR   OrthoDB; 436367at2; -.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0044780; P:bacterial-type flagellum assembly; IBA:GO_Central.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 1.10.8.540; -; 1.
DR   Gene3D; 3.40.30.60; -; 1.
DR   Gene3D; 3.40.50.12790; -; 1.
DR   InterPro; IPR042194; FHIPEP_1.
DR   InterPro; IPR042193; FHIPEP_3.
DR   InterPro; IPR042196; FHIPEP_4.
DR   InterPro; IPR025505; FHIPEP_CS.
DR   InterPro; IPR006301; FlhA.
DR   InterPro; IPR001712; T3SS_FHIPEP.
DR   PANTHER; PTHR30161; PTHR30161; 1.
DR   Pfam; PF00771; FHIPEP; 1.
DR   PIRSF; PIRSF005419; FlhA; 1.
DR   PRINTS; PR00949; TYPE3IMAPROT.
DR   TIGRFAMs; TIGR01398; FlhA; 1.
DR   PROSITE; PS00994; FHIPEP; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum biogenesis; Bacterial flagellum protein export;
KW   Cell membrane; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..678
FT                   /note="Flagellar biosynthesis protein FlhA"
FT                   /id="PRO_0000190009"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   678 AA;  75392 MW;  9C987330D32CA47D CRC64;
     MRGKEFWIIL AVVLILSAII IPIPALLLDL LLTLSITFSL TVLLLTFFIK NPLEFSSFPS
     VLLLGTLLRL SLNIAAARRI LLHGHEGTHA AGKVIEAFGK LVAGGDVVVG LIVFLIFIVI
     NFIVITKGAE RISEVAARFT LDALPGKQMS IDADLNAGLI TEEEAKRRRQ ELEKEANFYA
     AMDGASKFIR GDAIAALIIL FLSLVGGLLI GIGIRGMDLA SAVKTYTILS IGEGLASQVP
     ALLLSTAAGV LTTKMSSREN LGEAISEELT KQPRALLFSA GVLGFIGLIP GLPTLPFLAM
     SAILAGAYYL VQQSLKEREL KELEKLAQEK TKEKEEEGEE LIPQPEPITL EIGYALIPLV
     DESQGGQIPK KIKNLRKQIA KEYGVIVPLI HIRDNLRLKP NEYRILIKGI EIDRYELMPG
     HYLAVNLGNA KGPIEGIETY DPAFKIKAYW ITEDKKEEAQ KLGYMVVDAE TVLITHLSEV
     IKRNLHELLT RNEVMELIEM LSKKYPKVVK EIVPEQVPIS IIHRVLQNLL REGIPVNDLL
     TILETLADYI EQTKDPDLLT EYVRQALSKR ITRMYLTNGT LYAIALSPKV EAKLVKFLKE
     NREDEFIDYV LNTLLPKIKN EIVKFAQYGA VPVLLTSGEV RRFVRKTIEP YLSELAVLSY
     NELEKQVNIK IIGIVDED